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牙髓炎中表观遗传调控细胞凋亡的研究进展
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Abstract:
牙髓炎是发生于牙髓组织的炎性病变，持续发展会导致根尖周炎及骨组织缺损，严重破坏牙齿功能，影响患者的口腔健康及日常生活，造成时间、经济损失。细胞凋亡是基因控制的一种程序性细胞死亡，其表观遗传调节主要包括非编码RNA (non-coding RNA, ncRNA)转录调控、DNA甲基化和组蛋白修饰等。本文通过对表观遗传在牙髓炎进展中对细胞凋亡的调控机制和潜在作用作一综述，旨在丰富牙髓炎症的机制背景，为研究牙髓炎症的防治提供参考。
Pulpitis is an inflammatory disease that occurs in the pulp tissue. Continued development can lead to periapical periodontitis and bone tissue defect, seriously damage dental function, affect patients’ oral health and daily life, and cause time and economic losses. Apoptosis is a programmed cell death controlled by genes. Its epigenetic regulation mainly includes non-coding RNA (ncRNA) transcriptional regulation, DNA methylation and histone modification. This article reviews the regulatory mechanism and potential role of epigenetic on apoptosis in the progression of pulpitis, aiming to enrich the mechanism background of pulpitis and provide reference for the study of pulp inflammation prevention and treatment.
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