This paper provides a comprehensive review of the research progress and application of skin care ointments in the treatment of chronic eczema. Chronic eczema, a prevalent and frequently recurring inflammatory skin condition, significantly impacts patients’ quality of life. While traditional therapeutic agents, such as compound triamcinolone acetonide cream, demonstrate certain efficacy, they also present limitations. Skin care ointments, with their distinct advantages, have garnered increasing attention in the treatment of chronic eczema. This article details the pathogenesis of chronic eczema, the characteristics and limitations of conventional therapeutic drugs, and primarily discusses the mechanisms of action, clinical application outcomes, and future research directions of skin care ointments. The aim is to provide a more comprehensive theoretical foundation and treatment strategy for the clinical management of chronic eczema.
References
[1]
Hay, J.R., Johns, E.N., Williams, C.H., et al. (2014) The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions. Journal of Investigative Dermatology, 134, 1527-1534. https://doi.org/10.1038/jid.2013.446
[2]
Ständer, S. (2021) Atopic Dermatitis. The New England Journal of Medicine, 384, 1136-1143. https://doi.org/10.1056/NEJMra2023911
[3]
Eyerich, K., Brown, J.S., White, P.E.B., et al. (2018) Human and Computational Models of Atopic Dermatitis: A Review and Perspectives by an Expert Panel of the International Eczema Council. The Journal of Allergy and Clinical Immunology, 143, 36-45. https://doi.org/10.1016/j.jaci.2018.10.033
[4]
Wang, X. and Liu, L. (2021) Comparative Study on the Clinical Effects of Skin Care Ointment and Compound Triamcinolone Acetonide Cream on Patients with Dermatitis and Eczema. Medical Diet Therapy and Health, 19, 48-49.
[5]
Lang, M.B., Balermpas, P., Bauer, A., et al. (2024) S2k Guideline Basal Cell Carcinoma of the Skin (Update 2023). Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology: JDDG, 22, 1697-1714. https://doi.org/10.1111/ddg.15566
[6]
Zhao, B. (2018) Comparison of the Clinical Efficacy of Compound Flumethasone Ointment and Compound Triamcinolone Acetonide Cream in Patients with Dermatitis and Eczema. Anti-Infective Pharmacy, 15, 1065-1066.
[7]
Li, Q.Y., Mao, H.H., Yu, Y., et al. (2024) Clinical Study of Dehumidifying and Antipruritic Ointment Combined with Compound Triamcinolone Acetonide Cream in the Treatment of Perianal Eczema. Modern Drugs and Clinics, 39, 1814-1818.
[8]
Zhang, Y.M. (2013) Simultaneous Determination of Triamcinolone Acetonide Acetate, Diphenhydramine Hydrochloride and Miconazole Nitrate in Compound Triamcinolone Acetonide Cream by RP-HPLC. China Pharmacy, 24, 2763-2765.
[9]
Su, H., Pan, J., Xia, S.H., et al. (2010) Prescription Screening and Stability Study of Compound Triamcinolone Acetonide Cream. China Pharmaceutical Industry, 19, 39-41.