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mir-21-5p在多项恶性肿瘤中的机制及研究进展
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Abstract:
mir-21-5p作为一种微小RNA (microRNA)，在生物学领域中具有极其重要的作用，它参与多种生物活动，代谢的过程。其中mir-21-5p在多种癌症的发生发展过程中表现尤为突出。所以使得其在癌症研究中极其关键，它与多种癌症的生物学行为——增殖，迁移，侵袭有着密切关系。目前已知的多种癌症中，如肺癌，胃癌等，均存在进展较快，发现较晚的情况。尽管各类靶向及免疫治疗手段较为成熟，但仍然无法改变患者因发现晚带来的愈后较差结果。所以，我们迫切地需要一种早期确诊标志物和相对应的靶向治疗或免疫治疗的治疗靶点，该标志物需要满足特异性高，敏感度高的特点。因此，探寻mir-21-5p通过相应的靶基因，调控相应的信号传导通路，最终影响肿瘤细胞的发生发展，本文就此进行综述。
mir-21-5p is a microRNA that plays a crucial role in biological processes and various metabolic activities. Its significance is particularly evident in the development and progression of multiple cancers, making it a critical focus in cancer research due to its close association with biological behaviors such as proliferation, migration, and invasion of cancer cells. Many known cancers, including lung cancer and gastric cancer, often progress rapidly and are diagnosed at later stages. Despite advancements in targeted and immunotherapy approaches, the prognosis for patients diagnosed late remains poor. Therefore, there is an urgent need for early diagnostic biomarkers and corresponding targets for targeted or immunotherapy, which should be highly specific and sensitive. This review explores how mir-21-5p regulates relevant signaling pathways through its target genes, ultimately influencing tumor cell development.
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