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Bioprocess 2025
铁死亡和脂质代谢在肝细胞癌中的研究进展
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Abstract:
肝细胞癌(Hepatocellular carcinoma, HCC)隐匿性高，多数患者确诊时已处于中晚期，导致总体生存率低，预后不佳。铁死亡(Ferroptosis)是一种由铁依赖性致死水平的脂质过氧化引发，进而导致细胞出现特征性线粒体及坏死样变化的特殊死亡方式。脂质代谢(Lipid metabolism)在癌症发展进程中的重要性日益凸显，癌细胞生存、生长、增殖、侵袭和转移过程中所需的大量能量，依赖重新编程的脂质代谢提供支持。现有研究表明，铁死亡在HCC的生存和增殖中发挥着关键作用；脂质代谢与HCC的发生发展紧密相关，已成为HCC治疗的重要靶点。本文就近年来铁死亡和脂质代谢在HCC领域的研究进展作一综述，旨在为探寻HCC治疗的新靶点提供参考依据，以期为改善HCC患者的治疗效果和预后状况提供新思路。
Hepatocellular carcinoma (HCC) is a common malignant tumor worldwide with high concealment. Most patients are diagnosed at an advanced stage, resulting in low overall survival rates and poor prognosis. Ferroptosis is a special mode of cell death characterized by iron-dependent lethal levels of lipid peroxidation, leading to characteristic mitochondrial and necrotic-like changes in cells. Lipid metabolism has increasingly been highlighted for its importance in cancer development. Cancer cells rely on reprogrammed lipid metabolism to support the large amounts of energy required for survival, growth, proliferation, invasion, and metastasis. Existing studies have shown that ferroptosis plays a key role in the proliferation, migration, and apoptosis of HCC; lipid metabolism is closely related to the occurrence and development of HCC and has become an important target for HCC treatment. This review summarizes the recent research progress of ferroptosis and lipid metabolism in the field of HCC, aiming to provide reference for exploring new targets for HCC treatment and to offer new ideas for improving the therapeutic effects and prognosis of HCC patients.
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