|
|
中医药治疗桥本甲状腺炎研究进展
|
Abstract:
桥本甲状腺炎(Hashimoto thyroiditis, HT)是一种逐年高发的自身免疫性甲状腺疾病，突出表现为，血清中甲状腺球蛋白抗体(Thyroglobulin antibody, TGAb)、甲状腺过氧化物酶抗体(Thyroid peroxidase antibody, TPOAb)显著升高，可能伴有甲状腺功能改变，病情迁延难愈。目前西医在治疗HT上方法有限，而中医药治疗HT能够有针对性地辨病、辩证施治，临床上也有良好的疗效。因此本文根据HT患者甲状腺功能有无异常分为三期(甲亢期、甲功正常期、甲减期)，来论述中医药治疗桥本甲状腺炎，以期提高疾病的辅助治疗效果。
Hashimoto’s thyroiditis (Hashimoto thyroiditis, HT) is a high incidence of autoimmune thyroid disease year by year, for the outstanding performance, serum thyroglobulin antibody (Thyroglobulin antibody, TGAb), thyroid peroxidase antibody (Thyroid peroxidase antibody, TPOAb) significant rise, It may be accompanied by changes in thyroid function, and the disease is prolonged and difficult to cure. At present, Western medicine is limited in the treatment of HT, but Traditional Chinese medicine can discriminate and treat HT in a targeted way, and has good clinical effect. Therefore, according to the thyroid function of HT patients is divided into three stages (hyperthyroidism, normal thyroidism, hypothyroidism), to discuss the treatment of Hashimoto thyroiditis by Traditional Chinese medicine, in order to improve the auxiliary treatment effect of the disease.
| [1] | Bogusławska, J., Godlewska, M., Gajda, E. and Piekiełko-Witkowska, A. (2022) Cellular and Molecular Basis of Thyroid Autoimmunity. European Thyroid Journal, 11, e210024. https://doi.org/10.1530/etj-21-0024 |
| [2] | Bogović Crnčić, T., Ćurko-Cofek, B., Batičić, L., Girotto, N., Tomaš, M.I., Kršek, A., et al. (2024) Autoimmune Thyroid Disease and Pregnancy: The Interaction between Genetics, Epigenetics and Environmental Factors. Journal of Clinical Medicine, 14, Article 190. https://doi.org/10.3390/jcm14010190 |
| [3] | 王福凯, 马双双, 梁栋. 桥本氏甲状腺炎病因病机与中医命名思考[J]. 时珍国医国药, 2018, 29(12): 2998-3000. |
| [4] | 高青, 简立信, 许金国, 等. 桥本甲状腺炎病因病机与临床治疗研究进展[J]. 中国中药杂志, 2012, 37(20): 3003-3006. |
| [5] | 韩静, 刘守尧. 桥本氏甲状腺炎中西医治疗研究进展[J]. 中华中医药杂志, 2019, 34(11): 5327-5330. |
| [6] | 黄雯洁, 沈劼, 郭丽. 中医辨治甲状腺功能亢进症研究进展[J]. 中国中医基础医学杂志, 2018, 24(11): 1646-1648. |
| [7] | 幸享玲, 陈璐瑶, 王烨曼, 等. 甲状腺功能亢进症的中医药研究进展[J/OL]. 陕西中医药大学学报: 1-5. http://kns.cnki.net/kcms/detail/61.1501.R.20241025.1011.008.html, 2025-01-24. |
| [8] | 李敏超, 吴敏, 周临娜, 等. 桥本甲状腺炎证治规律探讨[J]. 中华中医药杂志, 2017, 32(4): 1610-1612. |
| [9] | 田淋蓥, 张庚良, 和欢, 等. 丹栀逍遥散加减合甲巯咪唑片治疗甲状腺功能亢进症49例[J]. 湖南中医杂志, 2020, 36(11): 62-64. |
| [10] | 肖艳琪, 裴瑞霞, 郑艳, 等. 中医药干预桥本甲状腺炎相关信号通路研究进展[J/OL]. 中国实验方剂学杂志: 1-18. https://doi.org/10.13422/j.cnki.syfjx.20250128, 2025-01-24. |
| [11] | 段姗姗, 王永恒, 彭书旺, 等. 基于网络药理学探讨加味逍遥散治疗气滞痰阻型桥本氏甲状腺炎的作用机制[J]. 药物评价研究, 2020, 43(9): 1771-1779. |
| [12] | 郭凌宇. 培脾化湿方治疗脾虚湿阻痰凝型桥本甲状腺炎患者的疗效观察[D]: [硕士学位论文]. 合肥: 安徽中医药大学, 2024. |
| [13] | 刘慧, 赵俊云, 杨向竹, 等. 黄芪糖蛋白对胶原诱导性关节炎小鼠Th17/Treg细胞免疫平衡的影响[J]. 环球中医药, 2016, 9(12): 1454-1458. |
| [14] | 费驰媛. 加味益气聪明汤联合左甲状腺素钠片治疗桥本甲状腺炎伴甲状腺功能减退症的临床观察[D]: [硕士学位论文]. 银川: 宁夏医科大学, 2021. |
| [15] | 黄圆圆, 张元, 康利平, 等. 党参属植物化学成分及药理活性研究进展[J]. 中草药, 2018, 49(1): 239-250. |
| [16] | 何丽君, 江金井, 陈豪, 等. 淫羊藿药理作用和临床应用的研究进展[J]. 中医临床研究, 2020, 12(2): 17-20. |
