全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

脓毒症相关性脑病的中西医研究进展
Research Progress of Sepsis-Associated Encephalopathy in Traditional Chinese and Western Medicine

DOI: 10.12677/tcm.2025.143137, PP. 922-927

Keywords: 脓毒症相关性脑病,生理病理发病机制,中西医治疗
Sepsis-Associated Encephalopathy
, Physiological and Pathological Pathogenesis, Treatment of Traditional Chinese and Western Medicine

Full-Text   Cite this paper   Add to My Lib

Abstract:

脓毒症相关性脑病(SAE)是脓毒症引起的弥漫性脑功能障碍,该病发病机制复杂,临床表现多样,幸存者大多患有认知功能受损,严重影响生活质量。近年来有关西医常规治疗联合中医药治疗SAE的实验研究和临床观察持续增多,本文聚焦于SAE中西医发病机制,从中西医临床治疗方面展开研究,旨在为临床诊疗工作提供新思路。
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by sepsis. The pathogenesis of this disease is complex, and its clinical manifestations are diverse. Most survivors suffer from cognitive impairment, which seriously affects their quality of life. In recent years, experimental studies and clinical observations on the treatment of SAE with a combination of conventional Western medicine and traditional Chinese medicine have been increasing continuously. This article focuses on the pathogenesis of SAE from both traditional Chinese and Western medicine perspectives and conducts research on the clinical treatment of SAE in traditional Chinese and Western medicine, aiming to provide new ideas for clinical diagnosis and treatment.

References

[1]  Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., et al. (2016) The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315, 801-810.
https://doi.org/10.1001/jama.2016.0287
[2]  Chung, H., Wickel, J., Brunkhorst, F.M. and Geis, C. (2020) Sepsis-Associated Encephalopathy: From Delirium to Dementia? Journal of Clinical Medicine, 9, Article 703.
https://doi.org/10.3390/jcm9030703
[3]  Huang, Y., Chen, R., Jiang, L., Li, S. and Xue, Y. (2021) Basic Research and Clinical Progress of Sepsis-Associated Encephalopathy. Journal of Intensive Medicine, 1, 90-95.
https://doi.org/10.1016/j.jointm.2021.08.002
[4]  Haileselassie, B., Joshi, A.U., Minhas, P.S., Mukherjee, R., Andreasson, K.I. and Mochly-Rosen, D. (2020) Mitochondrial Dysfunction Mediated through Dynamin-Related Protein 1 (Drp1) Propagates Impairment in Blood Brain Barrier in Septic Encephalopathy. Journal of Neuroinflammation, 17, Article No. 36.
https://doi.org/10.1186/s12974-019-1689-8
[5]  Yu, Y., Feng, J., Lian, N., Yang, M., Xie, K., Wang, G., et al. (2020) Hydrogen Gas Alleviates Blood-Brain Barrier Impairment and Cognitive Dysfunction of Septic Mice in an Nrf2-Dependent Pathway. International Immunopharmacology, 85, Article ID: 106585.
https://doi.org/10.1016/j.intimp.2020.106585
[6]  Akrout, N., Sharshar, T. and Annane, D. (2009) Mechanisms of Brain Signaling during Sepsis. Current Neuropharmacology, 7, 296-301.
https://doi.org/10.2174/157015909790031175
[7]  Catalão, C.H.R., Santos-Júnior, N.N., da Costa, L.H.A., Souza, A.O., Alberici, L.C. and Rocha, M.J.A. (2016) Brain Oxidative Stress during Experimental Sepsis Is Attenuated by Simvastatin Administration. Molecular Neurobiology, 54, 7008-7018.
https://doi.org/10.1007/s12035-016-0218-3
[8]  Alexander, J.J., Jacob, A., Cunningham, P., Hensley, L. and Quigg, R.J. (2008) TNF Is a Key Mediator of Septic Encephalopathy Acting through Its Receptor, TNF Receptor-1. Neurochemistry International, 52, 447-456.
https://doi.org/10.1016/j.neuint.2007.08.006
[9]  Pierrakos, C., Attou, R., Decorte, L., Kolyviras, A., Malinverni, S., Gottignies, P., et al. (2014) Transcranial Doppler to Assess Sepsis-Associated Encephalopathy in Critically Ill Patients. BMC Anesthesiology, 14, Article No. 45.
https://doi.org/10.1186/1471-2253-14-45
[10]  Della Giovampaola, M., Cavalli, I. and Mascia, L. (2022) Neuropsychological Outcome of Critically Ill Patients with Severe Infection. Biomedicines, 10, Article 526.
https://doi.org/10.3390/biomedicines10030526
[11]  Caldas, J., Quispe-Cornejo, A.A., Crippa, I.A., Subira, C., Creteur, J., Panerai, R., et al. (2022) Cerebral Autoregulation Indices Are Not Interchangeable in Patients with Sepsis. Frontiers in Neurology, 13, Article 760293.
https://doi.org/10.3389/fneur.2022.760293
[12]  Cenini, G., Lloret, A. and Cascella, R. (2019) Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View. Oxidative Medicine and Cellular Longevity, 2019, Article ID: 2105607.
https://doi.org/10.1155/2019/2105607
[13]  Dumbuya, J.S., Li, S., Liang, L. and Zeng, Q. (2023) Paediatric Sepsis-Associated Encephalopathy (SAE): A Comprehensive Review. Molecular Medicine, 29, Article No. 27.
https://doi.org/10.1186/s10020-023-00621-w
[14]  Oliveira-Pelegrin, G.R., Basso, P.J. and Rocha, M.J.A. (2014) Cellular Bioenergetics Changes in Magnocellular Neurons May Affect Copeptin Expression in the Late Phase of Sepsis. Journal of Neuroimmunology, 267, 28-34.
https://doi.org/10.1016/j.jneuroim.2013.12.006
[15]  Fu, Q., Wu, J., Zhou, X., Ji, M., Mao, Q., Li, Q., et al. (2018) NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy. Inflammation, 42, 306-318.
https://doi.org/10.1007/s10753-018-0894-4
[16]  Wang, Y., Liu, X., Wang, Q. and Yang, X. (2020) Roles of the Pyroptosis Signaling Pathway in a Sepsis-Associated Encephalopathy Cell Model. Journal of International Medical Research, 48.
https://doi.org/10.1177/0300060520949767
[17]  唐振东, 李探, 曾浩, 等. 中医药治疗脓毒症相关性脑病研究进展[J]. 中国中医急症, 2024, 33(11): 2064-2068.
[18]  谭文章, 邓竣, 伍大华, 等. 脓毒症相关性脑病的中医药治疗作用机制研究进展[J]. 湖南中医杂志, 2023, 39(8): 197-200.
[19]  Zhang, D., Micek, S.T. and Kollef, M.H. (2015) Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients with Sepsis. Critical Care Medicine, 43, 2133-2140.
https://doi.org/10.1097/ccm.0000000000001140
[20]  雷紫涵, 吴晓静. 脓毒症相关性脑病的研究进展[J/OL]. 武汉大学学报(医学版), 1-6.
https://doi.org/10.14188/j.1671-8852.2024.0549, 2025-03-05.
[21]  Gofton, T.E. and Young, G.B. (2012) Sepsis-associated Encephalopathy. Nature Reviews Neurology, 8, 557-566.
https://doi.org/10.1038/nrneurol.2012.183
[22]  Pandharipande, P.P., Sanders, R.D., Girard, T.D., McGrane, S., Thompson, J.L., Shintani, A.K., et al. (2010) Effect of Dexmedetomidine versus Lorazepam on Outcome in Patients with Sepsis: An a Priori-Designed Analysis of the MENDS Randomized Controlled Trial. Critical Care, 14, Article No. R38.
https://doi.org/10.1186/cc8916
[23]  Xu, X., Liu, L., Wang, Y., Wang, C., Zheng, Q., Liu, Q., et al. (2019) Caspase-1 Inhibitor Exerts Brain-Protective Effects against Sepsis-Associated Encephalopathy and Cognitive Impairments in a Mouse Model of Sepsis. Brain, Behavior, and Immunity, 80, 859-870.
https://doi.org/10.1016/j.bbi.2019.05.038
[24]  单贝贝, 谢颖桢, 牛丽强, 等. 基于“卫气营血”理论辨治脓毒症相关性脑病经验[J]. 北京中医药, 2024, 43(6): 707-709.
[25]  黄坡, 赵京霞, 苏芮, 等. 刘清泉教授对脓毒症相关性脑病的认识及其中医研究思路探讨[J]. 世界中医药, 2018, 13(10): 2390-2392, 2395.
[26]  戴春钦, 林巧燕. 牛黄承气汤治疗脓毒症脑病临床疗效的观察[J]. 中医临床研究, 2020, 12(27): 98-100.
[27]  郑福奎, 唐农, 吴林, 等. 清瘟败毒饮对脓毒症相关性脑病大鼠脑组织与TLR4介导的炎性因子的影响[J]. 广西中医药, 2017, 40(2): 70-73.
[28]  梁道业, 林正佳, 黄捷敏, 等. 涤痰醒脑承气汤干预对脓毒症脑病患者脑损伤标志物的影响[J]. 中国社区医师, 2018, 34(29): 118-119.
[29]  张云海, 邓梦华, 马明远. 通窍活血方治疗血瘀型脓毒性脑病患者的临床疗效观察[J]. 中医临床研究, 2021, 13(7): 63-66.
[30]  钱风华, 朱亮, 顼志兵, 等. 升降散治疗脓毒症性脑病临床疗效观察[J]. 上海中医药杂志, 2010, 44(6): 48-50.
[31]  王琳, 吴建鹏, 余旭超, 等. 安宫牛黄丸治疗脓毒症相关性脑病患者的临床观察[J]. 中国中医急症, 2022, 31(8): 1246-1249.
[32]  赵利, 张伟, 王小红. 醒脑静注射液治疗脓毒症相关性脑病的效果评价[J]. 当代医药论丛, 2020, 18(1): 153-154.
[33]  冯铠滨, 邓海霞, 吴鑫宇, 等. 参附注射液调节急危重症患者免疫功能的研究进展[J]. 辽宁中医药大学学报, 2024, 26(10): 189-195.
[34]  袁翔, 李建国, 黄越, 等. 电针足三里激活胆碱能抗炎通路抗大鼠感染性休克[J]. 武汉大学学报(医学版), 2007(2): 203-206.
[35]  林武, 杨芳, 张扬, 等. 通督调神针法对脓毒症相关性脑病患者认知功能的影响[J]. 针刺研究, 2019, 44(12): 888-892.
[36]  张云海, 谢维, 柳松涛, 等. 醒脑开窍针刺法治疗脓毒症相关性脑病临床研究[J]. 新中医, 2024, 56(20): 116-120.
[37]  谷婷, 王鑫, 杨欢, 等. 电针对颅脑损伤大鼠神经功能及凋亡相关蛋白Cyt-C、Caspase-9表达的影响[J]. 中国针灸, 2020, 40(7): 749-755.

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133