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自噬在炎症性肠病免疫稳态的研究进展
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Abstract:
近年来，越来越多的研究表明，自噬在调节免疫反应和炎症中发挥着重要作用。肠道作为机体重要的免疫器官，其内部的免疫细胞在自噬过程中可能对肠道炎症的发生与发展产生深远的影响。随着自噬在IBD的研究深入，发现肠道免疫细胞的异常自噬，可显著削弱肠道的免疫平衡和黏膜屏障的完整性，后者是IBD出现病情进展的重要环节。本文将系统地回顾自噬与肠道炎症及肠道免疫细胞之间的相互关系，以期为相关疾病的防治提供新的思路和方向。
In recent years, more and more studies have shown that autophagy plays an important role in regulating immune response and inflammation. Intestinal tract is an important immune organ of the body, and its internal immune cells may have a profound impact on the occurrence and development of intestinal inflammation in the process of autophagy. With the in-depth study of autophagy in IBD, it has been found that abnormal autophagy of intestinal immune cells can significantly weaken the immune balance of the intestine and the integrity of the mucosal barrier, which is an important part of the progression of IBD. This article will systematically review the relationship between autophagy, intestinal inflammation and intestinal immune cells, in order to provide new ideas and directions for the prevention and treatment of related diseases.
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