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Bioprocess 2025
高脂饮食与焦虑症的关联及其作用机制的研究进展
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Abstract:
焦虑症(Anxiety)，又称为焦虑性神经症，是神经症这一大类疾病中最常见的一种，以焦虑情绪体验为主要特征，其高患病率、高复发率以及较高的自杀和致残率给社会带来了巨大的负担。近年来的研究表明，饮食习惯与焦虑症之间存在密切的联系。自改革开放以来，中国人的饮食模式发生了显著变化，其中高脂饮食(high-fat diet, HFD)在饮食结构中的比例不断增加，HFD是指吃大量富含脂肪的食物，会影响机体代谢、伤害肝脏、诱发肥胖及其并发症等多种疾病。已有大量研究证实，HFD可导致动物表现出焦虑和抑郁的情绪，但其对焦虑症的具体影响机制尚不完全明确。本文通过综合分析现有文献资料，探讨了HFD与焦虑症之间的关联性，并分析了HFD诱导焦虑症的潜在发病机制。
Anxiety, also known as anxiety neurosis, is the most common type of neurosis, characterized primarily by the experience of anxiety. Its high prevalence, high recurrence rate, and relatively high rates of suicide and disability place a significant burden on society. Recent studies have indicated a close relationship between dietary habits and anxiety disorders. Since the reform and opening up, there have been significant changes in the dietary patterns of Chinese people, with an increasing proportion of high-fat diet (HFD) in their dietary structure. HFD refers to the consumption of large amounts of foods rich in fat, which can affect metabolism, damage the liver, and induce obesity and its complications among various diseases. Numerous studies have confirmed that HFD can lead to anxiety and depressive behaviors in animals, but the specific mechanisms by which it affects anxiety disorders are not yet fully understood. This paper explores the association between HFD and anxiety disorders and analyzes the potential pathogenic mechanisms of HFD-induced anxiety disorders through a comprehensive analysis of existing literature.
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