|
|
无痛性泪腺腺样囊性癌一例
|
Abstract:
目的：探讨无痛性泪腺腺样囊性癌(Adenoid cystic carcinoma of lacrimal gland, LGACC)的临床特征，以提升对该罕见肿瘤的认识。方法：回顾性分析1例LGACC患者的临床资料，并结合国内外文献进行复习探讨。结果：患者因发现左眼进行性突出伴上睑下垂就诊，无疼痛等不适，影像学检查提示左眼眶内肿物，行眶内肿物摘除术，病理诊断为腺样囊性癌。术后接受全身化疗，随访6月未见肿瘤复发或转移。结论：无痛性泪腺腺样囊性癌罕见，因解剖位置隐匿导致诊断困难，需尽早手术干预并结合病理明确诊断。
Objective: To investigate the clinical features of painless adenoid cystic carcinoma of lacrimal gland (LGACC) in order to improve the understanding of this rare tumor. Methods: The clinical data of 1 patient with LGACC of lacrimal gland adenoid cystic carcinoma were analyzed retrospectively, and the literature at home and abroad was reviewed. Results: The patient presented with progressive proptosis of the left eye accompanied by ptosis, without experiencing pain or other discomfort. Imaging examination revealed left orbital mass and resection of orbital mass was performed. The postoperative pathology revealed adenoid cystic carcinoma. The patients received systemic chemotherapy after surgery, and no tumor recurrence or metastasis was found in 36 months of follow-up. Conclusion: Painless adenoid cystic carcinoma of lacrimal gland is rare and difficult to diagnose due to hidden anatomical location. Early surgical intervention and pathological diagnosis are necessary.
| [1] | Tang, W., Hei, Y. and Xiao, L. (2013) Recurrent Orbital Space-Occupying Lesions: A Clinicopathologic Study of 253 Cases. Chinese Journal of Cancer Research, 25, 423-429. |
| [2] | Chawla, B., Kashyap, S., Sen, S., Bajaj, M.S., Pushker, N., Gupta, K., et al. (2013) Clinicopathologic Review of Epithelial Tumors of the Lacrimal Gland. Ophthalmic Plastic & Reconstructive Surgery, 29, 440-445. https://doi.org/10.1097/iop.0b013e31829f3a0c |
| [3] | Bernardini, F.P., Devoto, M.H. and Croxatto, J.O. (2008) Epithelial Tumors of the Lacrimal Gland: An Update. Current Opinion in Ophthalmology, 19, 409-413. https://doi.org/10.1097/icu.0b013e32830b13e1 |
| [4] | Tellado, M.V., McLean, I.W., Specht, C.S. and Varga, J. (1997) Adenoid Cystic Carcinomas of the Lacrimal Gland in Childhood and Adolescence. Ophthalmology, 104, 1622-1625. https://doi.org/10.1016/s0161-6420(97)30086-4 |
| [5] | Rapidis, A.D., Givalos, N., Gakiopoulou, H., Faratzis, G., Stavrianos, S.D., Vilos, G.A., et al. (2005) Adenoid Cystic Carcinoma of the Head and Neck. Clinico-Pathological Analysis of 23 Patients and Review of the Literature. Oral Oncology, 41, 328-335. https://doi.org/10.1016/j.oraloncology.2004.12.004 |
| [6] | Ahmad, S.M., Esmaeli, B., Williams, M., Nguyen, J., Fay, A., Woog, J., et al. (2009) American Joint Committee on Cancer Classification Predicts Outcome of Patients with Lacrimal Gland Adenoid Cystic Carcinoma. Ophthalmology, 116, 1210-1215. https://doi.org/10.1016/j.ophtha.2008.12.049 |
| [7] | Esmaeli, B., Ahmadi, M.A., Youssef, A., Diba, R., Amato, M., Myers, J.N., et al. (2004) Outcomes in Patients with Adenoid Cystic Carcinoma of the Lacrimal Gland. Ophthalmic Plastic & Reconstructive Surgery, 20, 22-26. https://doi.org/10.1097/01.iop.0000105518.72611.4f |
| [8] | Esmaeli, B., Golio, D., Kies, M. and DeMonte, F. (2006) Surgical Management of Locally Advanced Adenoid Cystic Carcinoma of the Lacrimal Gland. Ophthalmic Plastic & Reconstructive Surgery, 22, 366-370. https://doi.org/10.1097/01.iop.0000232164.00208.b4 |
| [9] | Wright, J.E., Rose, G.E. and Garner, A. (1992) Primary Malignant Neoplasms of the Lacrimal Gland. British Journal of Ophthalmology, 76, 401-407. https://doi.org/10.1136/bjo.76.7.401 |
| [10] | Mallen-St. Clair, J., Arshi, A., Tajudeen, B., Abemayor, E. and St John, M. (2014) Epidemiology and Treatment of Lacrimal Gland Tumors: A Population-Based Cohort Analysis. JAMA Otolaryngology—Head & Neck Surgery, 140, 1110. https://doi.org/10.1001/jamaoto.2014.2846 |
| [11] | Andreasen, S., Esmaeli, B., Holstein, S.L., et al. (2017) An Update on Tumors of the Lacrimal Gland. Asia-Pacific Journal of Ophthalmology, 6, 159-172. |
| [12] | Qin, W., Chong, R., Huang, X., Liu, M. and Yin, Z.Q. (2011) Adenoid Cystic Carcinoma of the Lacrimal Gland: CT and MRI Findings. European Journal of Ophthalmology, 22, 316-319. https://doi.org/10.5301/ejo.5000015 |
| [13] | Williams, M.D., Al-Zubidi, N., Debnam, J.M., Shinder, R., DeMonte, F. and Esmaeli, B. (2010) Bone Invasion by Adenoid Cystic Carcinoma of the Lacrimal Gland: Preoperative Imaging Assessment and Surgical Considerations. Ophthalmic Plastic & Reconstructive Surgery, 26, 403-408. https://doi.org/10.1097/iop.0b013e3181df6ab9 |
| [14] | Zhang, M., Fathy, C., Breazzano, M.P., Hollar, M. and Barahimi, B. (2017) Intra-Arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. International Ophthalmology Clinics, 57, 143-152. https://doi.org/10.1097/iio.0000000000000158 |
| [15] | von Holstein, S.L., Rasmussen, P.K. and Heegaard, S. (2016) Tumors of the Lacrimal Gland. Seminars in Diagnostic Pathology, 33, 156-163. https://doi.org/10.1053/j.semdp.2015.10.002 |
| [16] | Anjum, S., Sen, S., Pushker, N., Bajaj, M.S., Kashyap, S., Bakhshi, S., et al. (2021) Prognostic Impact of Notch1 Receptor and Clinicopathological High‐Risk Predictors in Lacrimal Gland Adenoid Cystic Carcinoma. Acta Ophthalmologica, 99, e1467-e1473. https://doi.org/10.1111/aos.14812 |
| [17] | Lesueur, P., Rapeaud, E., De Marzi, L., Goudjil, F., Levy, C., Galatoire, O., et al. (2020) Adenoid Cystic Carcinoma of the Lacrimal Gland: High Dose Adjuvant Proton Therapy to Improve Patients Outcomes. Frontiers in Oncology, 10, Article 135. https://doi.org/10.3389/fonc.2020.00135 |
| [18] | Xu, B., Drill, E., Ho, A., Ho, A., Dunn, L., Prieto-Granada, C.N., et al. (2017) Predictors of Outcome in Adenoid Cystic Carcinoma of Salivary Glands: A Clinicopathologic Study with Correlation between MYB Fusion and Protein Expression. American Journal of Surgical Pathology, 41, 1422-1432. https://doi.org/10.1097/pas.0000000000000918 |
| [19] | Ho, A.S., Kannan, K., Roy, D.M., Morris, L.G.T., Ganly, I., Katabi, N., et al. (2013) The Mutational Landscape of Adenoid Cystic Carcinoma. Nature Genetics, 45, 791-798. https://doi.org/10.1038/ng.2643 |
| [20] | Liebig, C., Ayala, G., Wilks, J.A., Berger, D.H. and Albo, D. (2009) Perineural Invasion in Cancer: A Review of the Literature. Cancer, 115, 3379-3391. https://doi.org/10.1002/cncr.24396 |
| [21] | Ford, J.R., Rubin, M.L., Frank, S.J., Ning, J., Debnam, J.M., Bell, D., et al. (2020) Prognostic Factors for Local Recurrence and Survival and Impact of Local Treatments on Survival in Lacrimal Gland Carcinoma. British Journal of Ophthalmology, 105, 768-774. https://doi.org/10.1136/bjophthalmol-2020-316142 |
| [22] | Fu, Y., Zhang, X., Ding, Z., Zhu, N., Song, Y., Zhang, X., et al. (2021) Worst Pattern of Perineural Invasion Redefines the Spatial Localization of Nerves in Oral Squamous Cell Carcinoma. Frontiers in Oncology, 11, Article 766902. https://doi.org/10.3389/fonc.2021.766902 |
| [23] | Du, F., Zhou, C. and Gao, Y. (2016) Myoepithelial Differentiation in Cribriform, Tubular and Solid Pattern of Adenoid Cystic Carcinoma: A Potential Involvement in Histological Grading and Prognosis. Annals of Diagnostic Pathology, 22, 12-17. https://doi.org/10.1016/j.anndiagpath.2016.03.001 |
| [24] | Perzin, K.H., Gullane, P. and Clairmont, A.C. (1978) Adenoid Cystic Carcinomas Arising in Salivary Glands. A Correlation of Histologic Features and Clinical Course. Cancer, 42, 265-282. https://doi.org/10.1002/1097-0142(197807)42:1<265::aid-cncr2820420141>3.0.co;2-z |
| [25] | Osborn, D.A. (1977) Morphology and the Natural History of Cribriform Adenocarcinoma (Adenoid Cystic Carcinoma). Journal of Clinical Pathology, 30, 195-205. https://doi.org/10.1136/jcp.30.3.195 |
| [26] | van Weert, S., van der Waal, I., Witte, B.I., René Leemans, C. and Bloemena, E. (2015) Histopathological Grading of Adenoid Cystic Carcinoma of the Head and Neck: Analysis of Currently Used Grading Systems and Proposal for a Simplified Grading Scheme. Oral Oncology, 51, 71-76. https://doi.org/10.1016/j.oraloncology.2014.10.007 |
| [27] | Gamel, J.W. and Font, R.L. (1982) Adenoid Cystic Carcinoma of the Lacrimal Gland: The Clinical Significance of a Basaloid Histologic Pattern. Human Pathology, 13, 219-225. https://doi.org/10.1016/s0046-8177(82)80180-9 |
| [28] | Gao, X., Wu, J., Cao, M., Gao, S., Cen, X., Jiang, Y., et al. (2017) Cytokeratin-14 Contributes to Collective Invasion of Salivary Adenoid Cystic Carcinoma. PLOS ONE, 12, e0171341. https://doi.org/10.1371/journal.pone.0171341 |
| [29] | Mori, M., Kasai, T., Yuba, R., Chomette, G., Auriol, M. and Vaillant, J. (1990) Immunohistochemical Studies of S-100 Protein Α and Β Subunits in Adenoid Cystic Carcinoma of Salivary Glands. Virchows Archiv B Cell Pathology Including Molecular Pathology, 59, 115-123. https://doi.org/10.1007/bf02899395 |
| [30] | Epivatianos, A., Poulopoulos, A., Dimitrakopoulos, I., Andreadis, D., Nomikos, A., Vlahou, S., et al. (2007) Application of Α-Smooth Muscle Actin and C-Kit in the Differential Diagnosis of Adenoid Cystic Carcinoma from Polymorphous Low-Grade Adenocarcinoma. Oral Oncology, 43, 67-76. https://doi.org/10.1016/j.oraloncology.2006.01.004 |
| [31] | Seethala, R.R., Pasha, T.L., Raghunath, P.N., LiVolsi, V.A. and Zhang, P.J. (2008) The Selective Expression of CD43 in Adenoid Cystic Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 16, 165-172. https://doi.org/10.1097/pai.0b013e318036bf8c |
| [32] | Woo, V.L., Bhuiya, T. and Kelsch, R. (2006) Assessment of CD43 Expression in Adenoid Cystic Carcinomas, Polymorphous Low-Grade Adenocarcinomas, and Monomorphic Adenomas. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 102, 495-500. https://doi.org/10.1016/j.tripleo.2005.08.038 |
| [33] | Luo, X.L., Sun, M.Y., Lu, C.T. and Zhou, Z. (2006) The Role of Schwann Cell Differentiation in Perineural Invasion of Adenoid Cystic and Mucoepidermoid Carcinoma of the Salivary Glands. International Journal of Oral and Maxillofacial Surgery, 35, 733-739. https://doi.org/10.1016/j.ijom.2006.01.012 |
| [34] | Emanuel, P., Wang, B., Wu, M. and Burstein, D.E. (2005) P63 Immunohistochemistry in the Distinction of Adenoid Cystic Carcinoma from Basaloid Squamous Cell Carcinoma. Modern Pathology, 18, 645-650. https://doi.org/10.1038/modpathol.3800329 |
| [35] | Persson, M., Andrén, Y., Mark, J., Horlings, H.M., Persson, F. and Stenman, G. (2009) Recurrent Fusion of MYB and NFIB Transcription Factor Genes in Carcinomas of the Breast and Head and Neck. Proceedings of the National Academy of Sciences of the United States of America, 106, 18740-18744. https://doi.org/10.1073/pnas.0909114106 |
| [36] | Andersson, M.K., Afshari, M.K., Andrén, Y., Wick, M.J. and Stenman, G. (2017) Targeting the Oncogenic Transcriptional Regulator MYB in Adenoid Cystic Carcinoma by Inhibition of IGF1R/AKT Signaling. JNCI: Journal of the National Cancer Institute, 109, djx017. https://doi.org/10.1093/jnci/djx017 |
| [37] | Morelli, M.P., Calvo, E., Ordoñez, E., Wick, M.J., Viqueira, B., Lopez-Casas, P.P., et al. (2012) Prioritizing Phase I Treatment Options through Preclinical Testing on Personalized Tumorgraft. Journal of Clinical Oncology, 30, e45-e48. https://doi.org/10.1200/jco.2011.36.9678 |
| [38] | Calvo, E., Soria, J., Ma, W.W., Wang, T., Bahleda, R., Tolcher, A.W., et al. (2017) A Phase I Clinical Trial and Independent Patient-Derived Xenograft Study of Combined Targeted Treatment with Dacomitinib and Figitumumab in Advanced Solid Tumors. Clinical Cancer Research, 23, 1177-1185. https://doi.org/10.1158/1078-0432.ccr-15-2301 |
| [39] | Meldrum, M.L. (1998) Neoadjuvant Intracarotid Chemotherapy for Treatment of Advanced Adenocystic Carcinoma of the Lacrimal Gland. Archives of Ophthalmology, 116, 315-321. https://doi.org/10.1001/archopht.116.3.315 |
| [40] | Tse, D.T., Kossler, A.L., Feuer, W.J. and Benedetto, P.W. (2013) Long-term Outcomes of Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma. Ophthalmology, 120, 1313-1323. https://doi.org/10.1016/j.ophtha.2013.01.027 |
| [41] | Shields, J.A., Shields, C.L., Freire, J.E., Brady, L.W. and Komarnicky, L. (2003) Plaque Radiotherapy for Selected Orbital Malignancies: Preliminary Observations: The 2002 Montgomery Lecture, Part 2. Ophthalmic Plastic & Reconstructive Surgery, 19, 91-95. https://doi.org/10.1097/01.iop.0000056020.66654.33 |
| [42] | Douglas, J.G., Laramore, G.E., Austin-Seymour, M., Koh, W., Stelzer, K. and Griffin, T.W. (2000) Treatment of Locally Advanced Adenoid Cystic Carcinoma of the Head and Neck with Neutron Radiotherapy. International Journal of Radiation Oncology Biology Physics, 46, 551-557. https://doi.org/10.1016/s0360-3016(99)00445-9 |
| [43] | Sidrys, L.A., Fritz, K.J. and Variakojis, D. (1982) Fast Neutron Therapy for Orbital Adenoid Cystic Carcinoma. Annals of Ophthalmology, 14, 42-45. |
| [44] | Buchholz, T.A., Shimotakahara, S.G., Weymuller, E.A., Laramore, G.E. and Griffin, T.W. (1993) Neutron Radiotherapy for Adenoid Cystic Carcinoma of the Head and Neck. Archives of Otolaryngology—Head and Neck Surgery, 119, 747-752. https://doi.org/10.1001/archotol.1993.01880190043009 |
| [45] | Rose, G.E., Gore, S.K. and Plowman, N.P. (2019) Cranio-Orbital Resection Does Not Appear to Improve Survival of Patients with Lacrimal Gland Carcinoma. Ophthalmic Plastic & Reconstructive Surgery, 35, 77-84. https://doi.org/10.1097/iop.0000000000001177 |
| [46] | Yang, J., Zhou, C., Wang, Y., Fan, X. and Jia, R. (2019) Multimodal Therapy in the Management of Lacrimal Gland Adenoid Cystic Carcinoma. BMC Ophthalmology, 19, Article No. 125. https://doi.org/10.1186/s12886-019-1110-5 |
| [47] | Amin, M.B., Greene, F.L., Edge, S.B., Compton, C.C., Gershenwald, J.E., Brookland, R.K., et al. (2017) The Eighth Edition AJCC Cancer Staging Manual: Continuing to Build a Bridge from a Population‐Based to a More “Personalized” Approach to Cancer Staging. CA: A Cancer Journal for Clinicians, 67, 93-99. https://doi.org/10.3322/caac.21388 |
| [48] | Polito, E. and Leccisotti, A. (1993) Epithelial Malignancies of the Lacrimal Gland: Survival Rates after Extensive and Conservative Therapy. Annals of Ophthalmology, 25, 422-426. |
| [49] | Tse, D.T., Benedetto, P.W., Tse, B.C. and Feuer, W.J. (2022) Neoadjuvant Intra-Arterial Cytoreductive Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma: A Long-Term Follow-Up Study of a Trimodal Strategy. American Journal of Ophthalmology, 240, 239-251. https://doi.org/10.1016/j.ajo.2022.03.027 |
| [50] | Laurie, S.A., Ho, A.L., Fury, M.G., Sherman, E. and Pfister, D.G. (2011) Systemic Therapy in the Management of Metastatic or Locally Recurrent Adenoid Cystic Carcinoma of the Salivary Glands: A Systematic Review. The Lancet Oncology, 12, 815-824. https://doi.org/10.1016/s1470-2045(10)70245-x |
| [51] | Sessions, R.B., Lehane, D.E., Smith, R.J.H., Bryan, R.N. and Suen, J.Y. (1982) Intra-Arterial Cisplatin Treatment of Adenoid Cystic Carcinoma. Archives of Otolaryngology—Head and Neck Surgery, 108, 221-224. https://doi.org/10.1001/archotol.1982.00790520021007 |
| [52] | Kaplan, M.J., Johns, M.E. and Cantrell, R.W. (1986) Chemotherapy for Salivary Gland Cancer. Otolaryngology—Head and Neck Surgery, 95, 165-170. https://doi.org/10.1177/019459988609500206 |
