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Pharmacy Information 2025
血液外泌体作为肺癌诊断标志物的研究
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Abstract:
肺癌是全球高发病率和高死亡率的恶性肿瘤之一，目前缺乏有效的早期诊断手段。约75%的患者确诊时已处于晚期或发生远处转移，导致治疗效果不佳，预后不良。因此，实现肺癌的早期诊断对于显著提高患者的生存率具有至关重要的意义。近年来，血液外泌体作为肺癌诊断标志物的研究取得显著进展。研究表明，外泌体通过与肿瘤微环境相互作用，介导肿瘤细胞的生长、转移、免疫调节以及放化疗抵抗，影响肺癌的发生和发展，具有成为早期诊断标志物的潜力。本文综述了血液外泌体在肺癌诊断中的研究现状与进展。
Lung cancer is one of the malignant tumors with high morbidity and mortality worldwide, and there is a lack of effective means of early diagnosis. About 75% of patients are in advanced stages or have distant metastases when diagnosed, resulting in poor treatment and poor prognosis. Therefore, realizing early diagnosis of lung cancer is of crucial significance to significantly improve the survival rate of patients. In recent years, research on blood exosomes as diagnostic markers for lung cancer has made remarkable progress. Studies have shown that exosomes have the potential to become early diagnostic markers by interacting with the tumor microenvironment, mediating tumor cell growth, metastasis, immune regulation, and resistance to radiotherapy, and influencing the occurrence and development of lung cancer. This article reviews the current status and progress of research on blood exosomes in lung cancer diagnosis.
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