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工程化干细胞在组织再生领域的应用
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Abstract:
干细胞具有迁移、分化以及分泌各种治疗因子(如免疫调节因子)等功能，为攻克多种疾病难题提供了全新的思路与方向。当前，干细胞治疗虽已取得阶段性成果，但仍面临细胞存活率欠佳、靶向归巢效率低下、分化精准度不足等问题。为进一步提升干细胞的治疗效能并赋予其全新的功能特性，越来越多的研究致力于工程化干细胞改造，并应用到组织再生领域，且已初步展现出成效。本综述简要回顾干细胞的工程化策略，并重点阐述工程化干细胞在创伤修复、软骨愈合、骨修复、免疫调控等组织再生领域的应用进展。
Stem cells possess the abilities of migration, differentiation, and secretion of various therapeutic factors (such as immunomodulatory factors), which provide entirely new ideas and directions for conquering numerous disease challenges. In current clinical practice, although stem cell therapy has achieved phased results, there are still problems such as poor cell survival rate, low targeted homing efficiency, and insufficient differentiation accuracy. To further enhance the therapeutic efficacy of stem cells and endow them with new functional characteristics, an increasing number of studies are dedicated to the modification of engineered stem cells and their application in the field of tissue regeneration, and initial effects have been demonstrated. This review briefly reviews the engineering strategies of stem cells and focuses on elaborating the application progress of engineered stem cells in aspects such as wound repair, cartilage healing, bone repair, and immune regulation in tissue regeneration.
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