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木犀草素及其衍生物抗癌作用的研究进展
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Abstract:
木犀草素(3',4',5,7-四羟基黄酮)是一种天然的黄酮类化合物，通常以糖苷的形式广泛分布于多种水果和蔬菜中。木犀草素具有显著的抗肿瘤活性，具体作用机制主要包括抑制细胞增殖、促进细胞凋亡、阻止细胞周期进程、抑制细胞迁移与侵袭、抑制血管新生以及诱导自噬等。然而，由于木犀草素的生物利用度较低，这限制了其临床应用。因此，通过化学结构修饰，获得木犀草素的一系列衍生物，提高其生物利用度，保持或增强其原有的抗肿瘤活性已成为研究热点。本文综述了木犀草素及其衍生物的研究进展，旨在探讨其抗肿瘤作用的分子机制，为从天然产物出发进行药物设计和结构优化提供理论依据。
Luteolin (3',4',5,7-tetrahydroxyflavones) are naturally occurring flavonoids, usually in the form of glycosides, widely distributed in a variety of fruits and vegetables. Luteolin have significant anti-tumor activity, and the specific mechanism of action mainly includes inhibition of cell proliferation, promotion of apoptosis, blocking cell cycle progression, inhibition of cell migration and invasion, inhibition of vascular neogenesis, and induction of autophagy. However, due to the low bioavailability of luteolin, this limits its clinical application. Therefore, it has become a research hotspot to obtain a series of derivatives of luteolin through chemical structure modification to improve their bioavailability and maintain or enhance their original antitumor activities. This paper reviews the research progress of luteolin and their derivatives, aiming at exploring the molecular mechanism of their antitumor effects and providing theoretical basis for drug design and structure optimization from natural products.
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