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阿尔茨海默病早期诊断的潜在生物标记物
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Abstract:
阿尔茨海默病(Alzheimer’s Disease, AD)是老年人群中最常见的痴呆类型，其特点是认知功能下降、记忆力下降、严重者出现语言障碍，最终丧失独立生活能力，给患者和社会带来了沉重的负担。其潜在病理改变在症状出现前的几十年就已经存在，因此AD的早诊断、早干预对于高风险人群具有重要意义，能够大幅度提高患者预后并有效改善生活质量。本文将回顾当前AD在生物标记物方面的相关前沿文章，通过综述其研究进展寻找潜在标记物，为AD的早期诊断提供帮助。
Alzheimer’s Disease (AD) is the most common type of dementia among the elderly, characterized by cognitive decline, memory impairment, and, in severe cases, language disorders, ultimately leading to the loss of independent living abilities. This condition imposes a substantial burden on both patients and society. The underlying pathological changes of AD may exist for decades before the onset of clinical symptoms. Therefore, early diagnosis and intervention are of significant importance for high-risk populations, as they can substantially improve patient prognosis and quality of life. This paper will review the current cutting-edge articles related to AD in terms of biomarkers, search for potential markers for early diagnosis of AD by summarizing their research progress, and provide insights into the early diagnosis of Alzheimer’s disease.
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