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嗜酸性肉芽肿性血管炎合并膜性肾病病例报告1例及文献复习
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Abstract:
嗜酸性肉芽肿性血管炎(EGPA)是一种罕见的多系统性小血管炎，膜性肾病(MN)是导致肾病综合征的常见病因，其特点是肾小球基底膜出现免疫复合物沉积。尽管EGPA合并MN的病例较为罕见，但其潜在的病理机制可能涉及免疫系统的异常激活和自身免疫反应。本文报道1例嗜酸性肉芽肿性血管炎合并膜性肾病典型病例，总结其诊治要点，并复习相关文献。
Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare multi-systemic small-vessel vasculitis. Membranous Nephropathy (MN) is a common cause of nephrotic syndrome, characterized by immune complex deposition in the glomerular basement membrane. Although cases of EGPA combined with MN are rare, the underlying pathological mechanism may involve abnormal activation of the immune system and autoimmune reactions. This article reports a typical case of EGPA combined with MN, summarizes the key points of diagnosis and treatment and reviews relevant literature.
| [1] | Vaglio, A., Buzio, C. and Zwerina, J. (2013) Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss): State of the Art. Allergy, 68, 261-273. Https://doi.org/10.1111/all.12088 |
| [2] | White, J. and Dubey, S. (2023) Eosinophilic Granulomatosis with Polyangiitis: A Review. Autoimmunity Reviews, 22, Article ID: 103219. https://doi.org/10.1016/j.autrev.2022.103219 |
| [3] | Jennette, J.C., Falk, R.J., Andrassy, K., Bacon, P.A., Churg, J., Gross, W.L., et al. (1994) Nomenclature of Systemic Vasculitides. Arthritis & Rheumatism, 37, 187-192. Https://doi.org/10.1002/art.1780370206 |
| [4] | 高金玮, 田新平. 嗜酸性肉芽肿性多血管炎诊治进展[J]. 临床内科杂志, 2023, 40(8): 517-519. |
| [5] | Ronco, P., Plaisier, E. And Debiec, H. (2021) Advances in Membranous Nephropathy. Journal of Clinical Medicine, 10, Article 607. https://doi.org/10.3390/jcm10040607 |
| [6] | 嗜酸性肉芽肿性多血管炎诊治规范多学科专家共识编写组. 嗜酸性肉芽肿性多血管炎诊治规范多学科专家共识[J]. 中华结核和呼吸杂志, 2018, 41(7): 514-521. |
| [7] | 林燕凤, 张英秀, 付朝丽, 等. 2018年嗜酸性肉芽肿性多血管炎诊治规范专家共识解读[J]. 中国实用内科杂志, 2019, 39(5): 437-439. |
| [8] | Wechsler, M.E., Akuthota, P., Jayne, D., Khoury, P., Klion, A., Langford, C.A., et al. (2017) Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis. New England Journal of Medicine, 376, 1921-1932. https://doi.org/10.1056/nejmoa1702079 |
| [9] | 陈亚婷, 史秀岩, 周任. 嗜酸性肉芽肿性多血管炎伴膜性肾病1例[J]. 临床肾脏病杂志, 2023, 23(9): 786-788. |
