Introduction: Invasive cancers of the vulva are uncommon; it is a pathology of the elderly. More and more young women are concerned. Objectives: To study and analyze vulvar cancer in our context. Patients and Method: Retrospective, descriptive and analytical study carried out in the Gynecology Department of the Owendo University Hospital over a period of 5 years from 2020 to 2024. All cancer cases of the period were concerned and we included vulvar cancers. We studied the epidemiological, clinical and therapeutic aspects. Results: We collected 5 files, the median age was 41.8 years [30 - 57 years], the average consultation time was 18 months [12 - 36 months]. Ulcerated, budding, and itchy lesions were present in 80% of cases. Invasive squamous cell carcinoma was the histological type present in all patients. Surgery was performed in 40% of cases. Concomitant radiochemotherapy (CRC) was offered in all patients. HIV was the comorbidity found in 100% of cases. Conclusion: Vulvar cancers are rare. They are often seen at advanced stages because of their location, the taboo nature they represent on the one hand and underdiagnosis on the other.
References
[1]
Conte, A.B., Sano, A.A., Belhaj, Y., et al. (2023) Epidemiological, Clinical, Histological Profile and Management of Vulvar Cancers. EC Gynaecology, 12, 1-8.
[2]
(2024) Centre Expert Régional des Cancers Gynécologiques et du réseau national Tu-meurs Malignes Rares Gynécologiques (TMRG). Cancer de la vulve: Généralités. https://www.icm.unicancer.fr/fr/pathologies/cancers-gynecologiques/cancer-de-la-vulve
[3]
Ramirez, P.T. and Salvo, G. (2023) Cancer de la vulve. https://www.msdmanuals.com/fr/professional/gyn%C3%A9cologie-et-obst%C3%A9trique/tumeurs-gyn%C3%A9cologiques/cancer-de-la-vulve
[4]
Hernández, A. (2023) Le tabou qui subsiste sur la vulve et la façon dont il retarde le diagnostic du cancer. https://www.bbc.com/afrique/articles/cq5ppjxld19o
[5]
Madsen, B.S., Jensen, H.L., van den Brule, A.J.C., Wohlfahrt, J. and Frisch, M. (2008) Risk Factors for Invasive Squamous Cell Carcinoma of the Vulva and Vagina—Population-Based Case-Control Study in Denmark. International Journal of Cancer, 122, 2827-2834. https://doi.org/10.1002/ijc.23446
[6]
Rowhani‐Rahbar, A., Hawes, S.E., Sow, P.S., Toure, P., Feng, Q., Dem, A., et al. (2007) The Impact of HIV Status and Type on the Clearance of Human Papillomavirus Infection among Senegalese Women. The Journal of Infectious Diseases, 196, 887-894. https://doi.org/10.1086/520883
[7]
Dièye, A., Wembulua Shinga, B., Tendeng, J.N., Diedhiou, M.N., Seck, B., Ndong, A., et al. (2020) Carcinome épidermoïde de la vulve chez une patiente infectée par le VIH-1 en échec de traitement antirétroviral de première ligne. Pan African Medical Journal, 36, Article 181. https://doi.org/10.11604/pamj.2020.36.181.20628
[8]
Zongo, N., Korsaga Somé, N., Ouédraogo, S., Ouédraogo, A.S., Zamané, H., Zida, M., et al. (2019) Cancer de la vulve: Stades diagnostiques, traitement et survie dans un pays aux ressources limitées (Burkina Faso). Bulletin du Cancer, 106, 1057-1063. https://doi.org/10.1016/j.bulcan.2019.07.008
[9]
Zaidi, H., Mouhajir, N., Mejjaoui, S.E., Kacemi, H.E., Hassouni, K., Kebdani, T., et al. (2013) Cancers primitifs invasifs de la vulve: Expérience de l’Institut National d’Oncologie de Rabat. Pan African Medical Journal, 15, Article 146. https://doi.org/10.11604/pamj.2013.15.146.2890
[10]
Dahbi, Z., Elmejjatti, F., Naciri, F., Guerouaz, A., Oabdelmoumen, A., Sbai, A., et al. (2018) Vulvar Cancer Treatment Options: Experience in the Oncology Center in Oujda. Pan African Medical Journal, 31, Article 182. https://doi.org/10.11604/pamj.2018.31.182.13812
[11]
Raimond, E., Mimoun, C., Ambroise, C., Huchon, C., Ouldamer, L., Koskas, M., et al. (2023) Étude descriptive des cancers de la vulve en fonction de la vulnérabilité des patientes liée à l’âge: Étude multicentrique. GynécologieObstétriqueFertilité & Sénologie, 51, 106. https://doi.org/10.1016/j.gofs.2022.11.143
[12]
Brown, J.E., Sunborg, M.J., Kost, E., Cosin, J.A. and Winter, W.E. (2005) Vulvar Cancer in Human Immunodeficiency Virus-Seropositive Premenopausal Women: A Case Series and Review of the Literature. Journal of Lower Genital Tract Disease, 9, 7-10. https://doi.org/10.1097/00128360-200501000-00003
[13]
Pautier, P., Morice, P. and DeCrevoisier, R. (2002) Cancer du col et infection à VIH. Bulletin du Cancer, 90, 399-404.
[14]
Rogers, L.J. and Cuello, M.A. (2018) Cancer of the Vulva. International Journal of Gynecology & Obstetrics, 143, 4-13. https://doi.org/10.1002/ijgo.12609
[15]
Gien, L.T., Slomovitz, B., Van der Zee, A. and Oonk, M. (2023) Phase II Activity Trial of High-Dose Radiation and Chemosensitization in Patients with Macrometastatic Lymph Node Spread after Sentinel Node Biopsy in Vulvar Cancer: Groningen International Study on Sentinel Nodes in Vulvar Cancer III (GROINSS-V III/NRG-GY024). International Journal of Gynecological Cancer, 33, 619-622. https://doi.org/10.1136/ijgc-2022-004122
[16]
Oonk, M.H.M., Slomovitz, B., Baldwin, P.J.W., van Doorn, H.C., van der Velden, J., de Hullu, J.A., et al. (2021) Radiotherapy versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients with Micrometastases in the Sentinel Node: Results of GROINSS-V II. Journal of Clinical Oncology, 39, 3623-3632. https://doi.org/10.1200/jco.21.00006
[17]
Oonk, M.H.M., Planchamp, F., Baldwin, P., Bidzinski, M., Brännström, M., Landoni, F., et al. (2017) European Society of Gynaecological Oncology Guidelines for the Management of Patients with Vulvar Cancer. International Journal of Gynecological Cancer, 27, 832-837. https://doi.org/10.1097/igc.0000000000000975
[18]
Deppe, G., Mert, I., Belotte, J. and Winer, I.S. (2013) Chemotherapy of Vulvar Cancer: A Review. Wiener klinischeWochenschrift, 125, 119-128. https://doi.org/10.1007/s00508-013-0338-y
[19]
Azaïs, H., Pauphilet, V., Belghiti, J., Nikpayam, M., Gonthier, C., Maingon, P., et al. (2019) Mise à jour concernant la prise en charge du cancer de la vulve: Les recommandations de l’Assistance publique-hôpitaux de Paris. Bulletin du Cancer, 106, 371-378. https://doi.org/10.1016/j.bulcan.2019.01.017
[20]
Kheirbek, N. (2023) Impact pronostic du nombre de ganglions prélevés dans les cancers de vulves: Une étude francogyn. GynécologieObstétriqueFertilité & Sénologie, 51, 105-106. https://doi.org/10.1016/j.gofs.2022.11.142