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WHtR、VFA与PCOS合并超重/肥胖患者生殖内分泌指标的相关性研究
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Abstract:
目的：探讨腰高比(WHtR)、内脏脂肪面积(VFA)对多囊卵巢综合征(PCOS)合并超重/肥胖患者生殖内分泌指标的相关性。旨在为PCOS合并超重/肥胖的辅助诊断和风险预测提供新依据。方法：本研究选取2023年9月至2024年5月期间，在包头医学院第一附属医院的内分泌科与妇产科治疗的85例PCOS患者作为研究样本，并选择同期在本院进行健康检查的30位女性作为对照组。收集研究对象临床基本资料，包括患者的年龄、身高、腰围、体重、VFA、SFA。收集临床生化指标包括性激素六项和AMH(抗缪勒氏管激素)的结果，通过生物电阻抗法测量内脏脂肪面积(VFA)和皮下脂肪面积(SFA)，结果以平方厘米(cm2)为单位表示。各项指标的统计学分析则使用SPSS 29.0软件对三组研究对象的数据进行处理，Pearson法分析PCOS合并超重/肥胖患者WHtR、VFA与生殖内分泌指标的相关性。结果：超重/肥胖组患者的体重、体质指数(BMI)、腰围、腰高比、VFA及SFA均显著高于健康对照组和正常体重组(P < 0.05)。年龄、身高、VSR三组间未见显著差异(P > 0.05)。健康对照组、正常体重组、超重/肥胖组患者在睾酮(T)、泌乳素(PRL)、LH/FSH (黄体生成素/卵泡刺激素)、AMH中具有显著差异(P < 0.05)；与健康对照组相比，正常体重组和超重/肥胖组患者的雌二醇(E2)水平显著升高(P < 0.05)；健康对照组和正常体重组的LH水平均低于超重/肥胖组(P < 0.05)；FSH和孕酮(P)水平在三组间无显著差异(P > 0.05)。三组患者在吸烟、饮酒、运动上无显著差异，健康对照组、正常体重组比超重/肥胖组在饮食上更倾向于低盐低脂，具有显著差异(P < 0.05)。采用Pearson相关性分析发现，PCOS合并超重/肥胖患者腰高比与AMH水平呈负相关(r = ？0.484, P < 0.05)，与E2、T、FSH、LH、P、PRL、LH/FSH水平无相关性(P > 0.05)；VFA与LH水平呈负相关(r = ？0.267, P < 0.05)，与E2、T、FSH、P、PRL、LH/FSH、AMH水平无相关性(P > 0.05)；腰高比与VFA呈正相关(r = 0.368, P < 0.05)。结论：WHtR、VFA与PCOS合并超重/肥胖患者生殖内分泌指标具有相关性，为疾病诊断和预测提供了新的思路。
Objective: To explore the correlation between WHtR (WHtR) and visceral fat area (VFA) on reproductive endocrine indexes of patients with polycystic ovary syndrome (PCOS) complicated with overweight/obesity. It aims to provide a new basis for the auxiliary diagnosis and risk prediction of PCOS complicated with overweight/obesity. Methods: During September 2023 to May 2024, 85 PCOS patients who were treated in the Department of Endocrinology and Obstetrics and Gynecology of the First Affiliated Hospital of Baotou Medical College of Inner Mongolia University of Science and Technology were selected as the research samples, and 30 women who underwent health examination in our hospital during the same period were selected as the control group. Collect the basic clinical data of the subjects, including age, height, waist circumference, weight, VFA and SFA. The results of clinical biochemical indexes including six sex hormones and AMH (anti-Miao Lei’s hormone) were collected. Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by bioelectrical impedance method, and the unit was cm2. SPSS 29.0 software was used to analyze the indexes of the three groups, and Pearson method was used to analyze the correlation between WHtR, VFA and reproductive endocrine indexes in PCOS patients with overweight/obesity. Results: The
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