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脑功能磁共振在青少年重性抑郁障碍奖赏网络的研究进展
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Abstract:
重性抑郁障碍(MDD)是以情绪低落、兴趣丧失和精力低下为主要症状的精神疾病。青少年时期是该病高发的关键阶段。研究表明，青少年MDD患者的奖赏系统功能异常，相关的大脑奖赏网络也存在改变，但这些变化的神经影像学机制尚不明确。功能磁共振成像(fMRI)作为一种无创脑功能成像技术，已广泛应用于MDD的脑功能研究。尽管如此，针对青少年群体奖赏网络的fMRI研究仍较为有限。本文综述了fMRI在青少年MDD奖赏网络研究中的应用进展。
Major depressive disorder (MDD) is a mental illness characterized by low mood, loss of interest, and low energy. Adolescence is a critical period for the high incidence of the disease. Studies have shown that adolescent patients with major depressive disorder have abnormal reward system function and related brain reward network changes, but the neuroimaging mechanism of these changes is still unclear. Functional magnetic resonance imaging (fMRI), as a non-invasive brain functional imaging technique, has been widely used in the study of brain function in MDD. Despite this, fMRI studies on the reward network in adolescent groups are still limited. This article reviews the application of functional magnetic resonance imaging in the study of reward network in adolescents with major depressive disorder.
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