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HSP47在心力衰竭等纤维化疾病中的作用
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Abstract:
热休克蛋白47 (HSP47)是一种内质网(ER)的常驻分子伴侣，对前胶原蛋白的正确折叠至关重要。HSP47表达的增加与纤维化等胶原相关疾病有关，例如肝、肺、消化道肿瘤等器官纤维化疾病。有研究表明，慢性心力衰竭患者心肌HSP47表达随心功能下降而升高，与左室舒张末期内径呈正相关，而与左室射血分数呈负相关，本文就HSP47结构，表达调控，与胶原蛋白的相互作用，及在心力衰竭等各类纤维化疾病中的作用进行描述。
Heat shock protein 47 (HSP47) is a resident molecular chaperone of the endoplasmic reticulum (ER) that is essential for the proper folding of procollagen. The increase in expression of HSP47 is associated with collagen-related diseases such as organ fibrosis in the liver, lungs, and gastrointestinal tract tumors. Studies have shown that cardiac HSP47 expression in patients with chronic heart failure decreases and increases in spontaneous function, which is positively correlated with left ventricular end-diastolic diameter, while negatively correlated with left ventricular ejection fraction. This paper describes the structure, expression regulation, interaction with collagen of HSP, and its role in various fibrotic diseases such as heart failure.
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