Objective: To study the relationship between cortical auditory evoked potential (CAEP) thresholds and behavioral thresholds in pediatric populations with sensorineural hearing loss (SNHL). Methods: Fifteen children (mean age 6.8 years) with bilateral SNHL underwent behavioral pure-tone audiometry and CAEP testing at 0.5, 1, 2, and 4 kHz. CAEP thresholds were determined using tone bursts, and correlations between CAEP and pure-tone thresholds were analyzed using Pearson correlation and t-tests. Results: A strong positive correlation was observed between P1 thresholds and behavioral thresholds across all test frequencies: 0.5 kHz (r = 0.765, p < 0.001), 1 kHz (r = 0.891, p < 0.001), 2 kHz (r = 0.871, p < 0.001), and 4 kHz (r = 0.922, p < 0.001). Correction values between P1 and behavioral thresholds were established: 0.5 kHz (11 dB HL), 1 kHz (9 dB HL), 2 kHz (12 dB HL), and 4 kHz (13 dB HL). Mean P1 latencies ranged from 145.19 ms to 149.06 ms, and N1 latencies ranged from 212.34 ms to 232.26 ms across frequencies. Conclusion: The strong correlation between P1 and behavioral thresholds demonstrates the reliability of CAEP testing for estimating auditory thresholds in children. These findings support the use of CAEP testing as a reliable objective tool for threshold estimation, particularly in cases where behavioral responses cannot be reliably obtained. When adjusted with frequency-specific correction values, CAEP testing provides a reliable method for assessing hearing thresholds in pediatric populations.
References
[1]
World Health Organization (2021, March 3) World Report on Hearing. Geneva. https://www.who.int/publications-detail-redirect/9789240020481
[2]
Stika, C.J., Eisenberg, L.S., Johnson, K.C., Henning, S.C., Colson, B.G., Ganguly, D.H., et al. (2015) Developmental Outcomes of Early-Identified Children Who Are Hard of Hearing at 12 to 18months of Age. EarlyHumanDevelopment, 91, 47-55. https://doi.org/10.1016/j.earlhumdev.2014.11.005
[3]
Yuan, X., Deng, K., Zhu, J., Xiang, L., Yao, Y., Li, Q., et al. (2020) Newborn Hearing Screening Coverage and Detection Rates of Hearing Impairment across China from 2008-2016. BMCPediatrics, 20, Article No. 360. https://doi.org/10.1186/s12887-020-02257-9
[4]
Musiek, F.E., Shinn, J., Chermak, G.D. and Bamiou, D. (2017) Perspectives on the Pure-Tone Audiogram. JournaloftheAmericanAcademyofAudiology, 28, 655-671. https://doi.org/10.3766/jaaa.16061
[5]
Van Dun, B., Dillon, H. and Seeto, M. (2015) Estimating Hearing Thresholds in Hearing-Impaired Adults through Objective Detection of Cortical Auditory Evoked Potentials. JournaloftheAmericanAcademyofAudiology, 26, 370-383. https://doi.org/10.3766/jaaa.26.4.5
[6]
British Society of Audiology (2022) Recommended Procedure: Cortical Auditory Evoked Potential (CAEP) Testing. https://www.thebsa.org.uk/wp-content/uploads/2023/10/OD104-40-BSA-Recommended-Procedure-CAEP.pdf
[7]
Sharma, A., Glick, H., Deeves, E. and Duncan, E. (2015). The P1 Biomarker for as-Sessing Cortical Maturation in Pediatric Hearing Loss: A Review. Otorinolaringologia, 65, 103-114. https://pubmed.ncbi.nlm.nih.gov/27688594/
[8]
Lightfoot, G. (2016) Summary of the N1-P2 Cortical Auditory Evoked Potential to Estimate the Auditory Threshold in Adults. SeminarsinHearing, 37, 1-8. https://doi.org/10.1055/s-0035-1570334
[9]
Sharma, A. and Dorman, M.F. (2006) Central Auditory Development in Children with Cochlear Implants: Clinical Implications. In: Cochlear and Brainstem Implants, Møller, A.R., Ed., Karger, 66-88. https://doi.org/10.1159/000094646
[10]
Zhang, Y., Wang, S., Liu, H., Zhang, J., Chen, J. and Mo, L. (2023) Hearing Assess-ment by Complex Wave N1-P2 of Cortical Auditory Evoked Potentials. Journal of Audiology and Speech Pathology, 31, 527-530. https://link.cnki.net/urlid/42.1391.r.20230327.1535.002
[11]
Durante, A.S., Wieselberg, M.B., Roque, N., Carvalho, S., Pucci, B., Gudayol, N., et al. (2017) Assessment of Hearing Threshold in Adults with Hearing Loss Using an Automated System of Cortical Auditory Evoked Potential Detection. BrazilianJournalofOtorhinolaryngology, 83, 147-154. https://doi.org/10.1016/j.bjorl.2016.02.016
[12]
Wong, L.L.N., Cheung, C. and Wong, E.C.M. (2008) Comparison of Hearing Thresholds Obtained Using Pure-Tone Behavioral Audiometry, the Cantonese Hearing in Noise Test (CHINT) and Cortical Evoked Response Audiometry. ActaOto-Laryngologica, 128, 654-660. https://doi.org/10.1080/00016480701642189
[13]
Cone, B. and Whitaker, R. (2013) Dynamics of Infant Cortical Auditory Evoked Potentials (CAEPs) for Tone and Speech Tokens. InternationalJournalofPediatricOtorhinolaryngology, 77, 1162-1173. https://doi.org/10.1016/j.ijporl.2013.04.030
He, S., Teagle, H.F.B., Roush, P., Grose, J.H. and Buchman, C.A. (2013) Objective Hearing Threshold Estimation in Children with Auditory Neuropathy Spectrum Disorder. TheLaryngoscope, 123, 2859-2861. https://doi.org/10.1002/lary.24137
[16]
Cardon, G. and Sharma, A. (2021) Cortical Neurophysiologic Correlates of Auditory Threshold in Adults and Children with Normal Hearing and Auditory Neuropathy Spectrum Disorder. AmericanJournalofAudiology, 30, 28-42. https://doi.org/10.1044/2020_aja-20-00062
[17]
Liégeois-Chauvel, C., Musolino, A., Badier, J.M., Marquis, P. and Chauvel, P. (1994) Evoked Potentials Recorded from the Auditory Cortex in Man: Evaluation and Topography of the Middle Latency Components. ElectroencephalographyandClinicalNeurophysiology/EvokedPotentialsSection, 92, 204-214. https://doi.org/10.1016/0168-5597(94)90064-7
[18]
Mukari, S.Z.S., Umat, C., Chan, S.C., Ali, A., Maamor, N. and Zakaria, M.N. (2020) Effects of Age and Type of Stimulus on the Cortical Auditory Evoked Potential in Healthy Malaysian Children. JournalofAudiologyandOtology, 24, 35-39. https://doi.org/10.7874/jao.2019.00262
[19]
Campbell, J., Cardon, G. and Sharma, A. (2011) Clinical Application of the P1 Cortical Auditory Evoked Potential Biomarker in Children with Sensorineural Hearing Loss and Auditory Neuropathy Spectrum Disorder. SeminarsinHearing, 32, 147-155. https://doi.org/10.1055/s-0031-1277236
[20]
Eggermont, J.J. and Ponton, C.W. (2003) Auditory-Evoked Potential Studies of Cortical Maturation in Normal Hearing and Implanted Children: Correlations with Changes in Structure and Speech Perception. ActaOto-Laryngologica, 123, 249-252. https://doi.org/10.1080/0036554021000028098
[21]
Xiong, S., Jiang, L., Wang, Y., Pan, T. and Ma, F. (2022) The Role of the P1 Latency in Auditory and Speech Performance Evaluation in Cochlear Implanted Children. NeuralPlasticity, 2022, 1-10. https://doi.org/10.1155/2022/6894794
[22]
Li, Y. L., Liu, X. H., Fu, X. X. and Qi, B. E. (2017). Characterization of Cortical Audi-Tory Evoked Potential (P1-N1-P2) in Normal Hearing Young Adults. JournalofClinicalOtorhinolaryngologyHeadandNeckSurgery, 31, 262-266. https://doi.org/10.13201/j.issn.1001-1781.2017.04.005
[23]
Dabbous, A., El-Shennawy, A., Hamdy, M. and Nabieh, S. (2020) Comparison of N1P2 Cortical Auditory Evoked Potential and Narrow-Band Chirp Auditory Steady State Potential in Hearing Threshold Detection in Adults. JournalofHearingScience, 10, 48-68. https://doi.org/10.17430/jhs.2020.10.4.6
