|
|
Chemerin与多囊卵巢综合征的关系及可能作用机制
|
Abstract:
多囊卵巢综合征(PCOS)作为育龄期女性常见的内分泌疾病，其人群中脂肪因子被不断研究，如脂联素等在正常女性中的循环水平与PCOS人群具有差异性。随着PCOS的相关研究越来越深入，Chemerin作为一种脂肪因子与PCOS有复杂的联系。本文就Chemerin在PCOS中的研究进展进行综述，旨在为Chemerin在PCOS的进一步研究中提出新的见解，为了解和治疗PCOS提供新的思路。
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age and has been extensively studied in the context of adipokine dysregulation. Among these adipokines, lipocalin demonstrates distinct circulating levels in PCOS patients compared to non-PCOS individuals. As research on PCOS advances, Chemerin, a multifunctional adipokine, has gained increasing attention due to its potential role in the pathophysiology of PCOS. This article reviews the current research progress on Chemerin in PCOS, aiming to provide novel insights for future investigations and to explore potential therapeutic strategies for PCOS management.
| [1] | Escobar-Morreale, H.F. (2018) Polycystic Ovary Syndrome: Definition, Aetiology, Diagnosis and Treatment. Nature Reviews Endocrinology, 14, 270-284. https://doi.org/10.1038/nrendo.2018.24 |
| [2] | Nagpal, S., Patel, S., Jacobe, H., DiSepio, D., Ghosn, C., Malhotra, M., et al. (1997) Tazarotene-induced Gene 2 (TIG2), a Novel Retinoid-Responsive Gene in Skin. Journal of Investigative Dermatology, 109, 91-95. https://doi.org/10.1111/1523-1747.ep12276660 |
| [3] | Chou, H., Teng, M., Hsu, L., Er, L., Wu, S. and Ko, Y. (2021) Circulating Chemerin Level Is Associated with Metabolic, Biochemical and Haematological Parameters—A Population‐Based Study. Clinical Endocrinology, 94, 927-939. https://doi.org/10.1111/cen.14441 |
| [4] | Ferland, D.J., Seitz, B., Darios, E.S., Thompson, J.M., Yeh, S.T., Mullick, A.E., et al. (2018) Whole-Body but Not Hepatic Knockdown of Chemerin by Antisense Oligonucleotide Decreases Blood Pressure in Rats. The Journal of Pharmacology and Experimental Therapeutics, 365, 212-218. https://doi.org/10.1124/jpet.117.245456 |
| [5] | Zhao, L., Leung, L.L. and Morser, J. (2022) Chemerin Forms: Their Generation and Activity. Biomedicines, 10, Article No. 2018. https://doi.org/10.3390/biomedicines10082018 |
| [6] | Zabel, B.A., Allen, S.J., Kulig, P., Allen, J.A., Cichy, J., Handel, T.M., et al. (2005) Chemerin Activation by Serine Proteases of the Coagulation, Fibrinolytic, and Inflammatory Cascades. Journal of Biological Chemistry, 280, 34661-34666. https://doi.org/10.1074/jbc.m504868200 |
| [7] | Reverchon, M., Cornuau, M., Rame, C., Guerif, F., Royere, D. and Dupont, J. (2012) Chemerin Inhibits IGF-1-Induced Progesterone and Estradiol Secretion in Human Granulosa Cells. Human Reproduction, 27, 1790-1800. https://doi.org/10.1093/humrep/des089 |
| [8] | Li, L., Huang, C., Zhang, X., Wang, J., Ma, P., Liu, Y., et al. (2013) Chemerin‐Derived Peptide c‐20 Suppressed Gonadal Steroidogenesis. American Journal of Reproductive Immunology, 71, 265-277. https://doi.org/10.1111/aji.12164 |
| [9] | Li, L., Ma, P., Huang, C., Liu, Y., Zhang, Y., Gao, C., et al. (2013) Expression of Chemerin and Its Receptors in Rat Testes and Its Action on Testosterone Secretion. Journal of Endocrinology, 220, 155-163. https://doi.org/10.1530/joe-13-0275 |
| [10] | Yoshimura, T. and Oppenheim, J.J. (2011) Chemokine-Like Receptor 1 (CMKLR1) and Chemokine (C-C Motif) Receptor-Like 2 (CCRL2); Two Multifunctional Receptors with Unusual Properties. Experimental Cell Research, 317, 674-684. https://doi.org/10.1016/j.yexcr.2010.10.023 |
| [11] | Tan, B.K., Chen, J., Farhatullah, S., Adya, R., Kaur, J., Heutling, D., et al. (2009) Insulin and Metformin Regulate Circulating and Adipose Tissue Chemerin. Diabetes, 58, 1971-1977. https://doi.org/10.2337/db08-1528 |
| [12] | Bauer, S., Bala, M., Kopp, A., Eisinger, K., Schmid, A., Schneider, S., et al. (2012) Adipocyte Chemerin Release Is Induced by Insulin without Being Translated to Higher Levels in Vivo. European Journal of Clinical Investigation, 42, 1213-1220. https://doi.org/10.1111/j.1365-2362.2012.02713.x |
| [13] | Kort, D.H., Kostolias, A., Sullivan, C. and Lobo, R.A. (2014) Chemerin as a Marker of Body Fat and Insulin Resistance in Women with Polycystic Ovary Syndrome. Gynecological Endocrinology, 31, 152-155. https://doi.org/10.3109/09513590.2014.968547 |
| [14] | Kabiri, N., Tabandeh, M.R. and Tabatabaie, S.R.F. (2014) Beneficial Effects of Pioglitazone and Metformin in Murine Model of Polycystic Ovaries via Improvement of Chemerin Gene Up-Regulation. DARU Journal of Pharmaceutical Sciences, 22, Article No. 39. https://doi.org/10.1186/2008-2231-22-39 |
| [15] | Bose, C., Mukherjee, B., Mukherjee, A., Pramanik, S., Saha, C., Mondal, A., et al. (2024) Serum Chemerin Levels Correlate with Severity of Dysglycemia in Young Adult Women with Polycystic Ovary Syndrome. Journal of the Endocrine Society, 8, bvae023. https://doi.org/10.1210/jendso/bvae023 |
| [16] | Takahashi, M., Okimura, Y., Iguchi, G., Nishizawa, H., Yamamoto, M., Suda, K., et al. (2011) Chemerin Regulates β-Cell Function in Mice. Scientific Reports, 1, Article No. 123. https://doi.org/10.1038/srep00123 |
| [17] | Ghosh, A.R., Bhattacharya, R., Bhattacharya, S., Nargis, T., Rahaman, O., Duttagupta, P., et al. (2016) Adipose Recruitment and Activation of Plasmacytoid Dendritic Cells Fuel Metaflammation. Diabetes, 65, 3440-3452. https://doi.org/10.2337/db16-0331 |
| [18] | Weigert, J., Neumeier, M., Wanninger, J., Filarsky, M., Bauer, S., Wiest, R., et al. (2010) Systemic Chemerin Is Related to Inflammation Rather than Obesity in Type 2 Diabetes. Clinical Endocrinology, 72, 342-348. https://doi.org/10.1111/j.1365-2265.2009.03664.x |
| [19] | Lima, P.D.A., Nivet, A., Wang, Q., Chen, Y., Leader, A., Cheung, A., et al. (2018) Polycystic Ovary Syndrome: Possible Involvement of Androgen-Induced, Chemerin-Mediated Ovarian Recruitment of Monocytes/Macrophages. Biology of Reproduction, 99, 838-852. https://doi.org/10.1093/biolre/ioy096 |
| [20] | Orisaka, M., Jiang, J., Orisaka, S., Kotsuji, F. and Tsang, B.K. (2009) Growth Differentiation Factor 9 Promotes Rat Preantral Follicle Growth by Up-Regulating Follicular Androgen Biosynthesis. Endocrinology, 150, 2740-2748. https://doi.org/10.1210/en.2008-1536 |
| [21] | Kobayashi, N., Orisaka, M., Cao, M., Kotsuji, F., Leader, A., Sakuragi, N., et al. (2009) Growth Differentiation Factor-9 Mediates Follicle-Stimulating Hormone-Thyroid Hormone Interaction in the Regulation of Rat Preantral Follicular Development. Endocrinology, 150, 5566-5574. https://doi.org/10.1210/en.2009-0262 |
| [22] | Kim, J.Y., Xue, K., Cao, M., Wang, Q., Liu, J., Leader, A., et al. (2013) Chemerin Suppresses Ovarian Follicular Development and Its Potential Involvement in Follicular Arrest in Rats Treated Chronically with Dihydrotestosterone. Endocrinology, 154, 2912-2923. https://doi.org/10.1210/en.2013-1001 |
| [23] | Wang, L., Zhong, Y., Ding, Y., Shi, X., Huang, J. and Zhu, F. (2014) Elevated Serum Chemerin in Chinese Women with Hyperandrogenic PCOS. Gynecological Endocrinology, 30, 746-750. https://doi.org/10.3109/09513590.2014.928687 |
| [24] | Li, X., Zhu, Q., Wang, W., Qi, J., He, Y., Wang, Y., et al. (2019) Elevated Chemerin Induces Insulin Resistance in Human Granulosa‐lutein Cells from Polycystic Ovary Syndrome Patients. The FASEB Journal, 33, 11303-11313. https://doi.org/10.1096/fj.201802829r |
| [25] | Wang, Q., Kim, J.Y., Xue, K., Liu, J., Leader, A. and Tsang, B.K. (2012) Chemerin, a Novel Regulator of Follicular Steroidogenesis and Its Potential Involvement in Polycystic Ovarian Syndrome. Endocrinology, 153, 5600-5611. https://doi.org/10.1210/en.2012-1424 |
| [26] | Yong, E.L., Hillier, S.G., Turner, M., Baird, D.T., Ng, S.C., Bongso, A., et al. (1994) Differential Regulation of Cholesterol Side-Chain Cleavage (p450scc) and Aromatase (p450arom) Enzyme mRNA Expression by Gonadotrophins and Cyclic AMP in Human Granulosa Cells. Journal of Molecular Endocrinology, 12, 239-249. https://doi.org/10.1677/jme.0.0120239 |
| [27] | Huang, R., Yue, J., Sun, Y., Zheng, J., Tao, T., Li, S., et al. (2015) Increased Serum Chemerin Concentrations in Patients with Polycystic Ovary Syndrome: Relationship between Insulin Resistance and Ovarian Volume. Clinica Chimica Acta, 450, 366-369. https://doi.org/10.1016/j.cca.2015.09.015 |
| [28] | Bozaoglu, K., Curran, J.E., Stocker, C.J., Zaibi, M.S., Segal, D., Konstantopoulos, N., et al. (2010) Chemerin, a Novel Adipokine in the Regulation of Angiogenesis. The Journal of Clinical Endocrinology & Metabolism, 95, 2476-2485. https://doi.org/10.1210/jc.2010-0042 |
| [29] | Kaur, J., Adya, R., Tan, B.K., Chen, J. and Randeva, H.S. (2010) Identification of Chemerin Receptor (chemr23) in Human Endothelial Cells: Chemerin-Induced Endothelial Angiogenesis. Biochemical and Biophysical Research Communications, 391, 1762-1768. https://doi.org/10.1016/j.bbrc.2009.12.150 |
| [30] | Wang, Y., Huang, R., Li, X., Zhu, Q., Liao, Y., Tao, T., et al. (2019) High Concentration of Chemerin Caused by Ovarian Hyperandrogenism May Lead to Poor IVF Outcome in Polycystic Ovary Syndrome: A Pilot Study. Gynecological Endocrinology, 35, 1072-1077. https://doi.org/10.1080/09513590.2019.1622087 |
| [31] | Kisielewska, K., Rytelewska, E., Gudelska, M., Kiezun, M., Dobrzyn, K., Bogus-Nowakowska, K., et al. (2020) Relative Abundance of Chemerin mRNA Transcript and Protein in Pituitaries of Pigs during the Estrous Cycle and Early Pregnancy and Associations with LH and FSH Secretion during the Estrous Cycle. Animal Reproduction Science, 219, Article ID: 106532. https://doi.org/10.1016/j.anireprosci.2020.106532 |
| [32] | Guo, X., Fu, Y., Xu, Y., Weng, S., Liu, D., Cui, D., et al. (2012) Chronic Mild Restraint Stress Rats Decreased CMKLR1 Expression in Distinct Brain Region. Neuroscience Letters, 524, 25-29. https://doi.org/10.1016/j.neulet.2012.06.075 |
| [33] | Helfer, G., Ross, A.W., Thomson, L.M., Mayer, C.D., Stoney, P.N., McCaffery, P.J., et al. (2016) A Neuroendocrine Role for Chemerin in Hypothalamic Remodelling and Photoperiodic Control of Energy Balance. Scientific Reports, 6, Article No. 26830. https://doi.org/10.1038/srep26830 |
| [34] | Yang, Y., Sun, L., Yu, Y., Xiao, T., Wang, B., Ren, P., et al. (2018) Deficiency of Gpr1 Improves Steroid Hormone Abnormality in Hyperandrogenized Mice. Reproductive Biology and Endocrinology, 16, Article No. 50. https://doi.org/10.1186/s12958-018-0363-9 |
| [35] | Li, R., Ma, C., Xiong, Y., Zhao, H., Yang, Y., Xue, L., et al. (2021) An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis. Biomolecules, 11, Article No. 857. https://doi.org/10.3390/biom11060857 |
