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茶与糖尿病视网膜病变的相关研究
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Abstract:
糖尿病视网膜病变(DR)是糖尿病(DM)患者常见的慢性并发症之一，已经成为全世界面临的较为严重的公共卫生负担。越来越多的证据表明，氧化应激和慢性炎症在DR的发展中起主导作用。目前，还没有可以预测和完全阻止DR进展的方法，为了避免不必要的视力损害，DR的预防和早期治疗必须引起重视。研究表明，茶除了具有抗氧化活性、减缓氧化应激和血管损伤的作用，能够通过影响新生血管、清除自由基减少视网膜损伤，此外，还具有抗炎作用，能减轻因高血糖引起的慢性炎症反应。本文将对茶在DR发生发展中的作用及其对DR的治疗作用和机制研究进展进行综述，为DR防治提供了新思路。
Diabetic retinopathy (DR) is one of the common chronic complications in patients with diabetes mellitus (DM) and has become one of the more serious public health burdens facing the world. There is growing evidence that oxidative stress and chronic inflammation play a dominant role in the development of DR. Currently, there is no method to predict and completely stop the progression of DR, and prevention and early treatment of DR must be emphasized in order to avoid unnecessary vision damage. Studies have shown that in addition to its antioxidant activity, slowing oxidative stress and vascular damage, tea is able to reduce retinal damage by affecting neovascularization and scavenging free radicals, in addition to its anti-inflammatory effect, which reduces chronic inflammatory responses due to hyperglycemia. This paper will review the role of tea in the development of DR and its therapeutic effects on DR and the progress of mechanism research, which provides new ideas in the prevention and treatment of DR.
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