Introduction: Considering a disease of postmenopausal women, there is a noted trend of increasing breast cancer cases among premenopausal women. Our study aimed to determine the main risk factors for breast cancer in women aged 40 and under. Materials and Methods: This was a case-control study with exhaustive sampling of all respondents with histological proof over a 12-month period, matched by age. For all statistical tests, we used a significance threshold of 5%. Additionally provided are the ORs and their 95% confidence intervals, the mean, and standard deviation. Results: We collected 65 cases and 130 controls. The frequency of breast cancer in women aged 40 and under was 35.5%. The mean age was 35.6 ± 4.5 years among cases compared to 32.1 ± 7.9 years among controls. A significantly positive association was detected in both univariate and multivariate analysis between age and breast cancer [(OR) = 10.30; 95% CI (1.99 - 53.23)] and [(OR) = 7.53; 95% CI (1.82 - 31.23)]; family history of breast cancer and breast cancer [(OR) = 9.99; 95% CI (1.43 - 69.58)]; smoking and breast cancer [OR = 13.11; 95% CI (1.05 - 163.30)]; sedentary lifestyle and breast cancer [OR = 3.36; 95% CI (1.01 - 11.17)]; and night work and breast cancer [(OR) = 72.05; 95% CI (8.15 - 637.25)]. Conclusion: Earlier systematic screening and regular follow-up should be conducted in young women in our context.
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