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Medical Diagnosis 2025
肠道菌群及其代谢物与结直肠癌的相关性研究进展
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Abstract:
结直肠癌是常见癌症也是人类癌症死亡的重要原因之一，其病因与多方面因素相关，其中肠道菌群紊乱与结直肠癌的发生和进展密切相关。肠道菌群能够通过释放多种代谢产物、蛋白质和大分子来与宿主的结肠上皮细胞和免疫细胞相互作用，从而促进肿瘤的发生。而益生菌本身结构及其代谢产物也能分泌多种肿瘤抑制分子。因此本研究对肠道菌群及其代谢物在结直肠癌的发生、防治中的作用进行综述。
Colorectal cancer is a common cancer and one of the important causes of human cancer death. Its etiology is related to many factors, among which gut microbes disturbance is closely related to the occurrence and progression of colorectal cancer. Gut microbes can promote tumor development by releasing a variety of metabolites, proteins, and macromolecules that interact with the host’s colon epithelial cells and immune cells. The structure of probiotics and their metabolites can also secrete a variety of tumor suppressor molecules. Therefore, this study reviewed the role of intestinal flora and its metabolites in the occurrence, prevention, and treatment of colorectal cancer.
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