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肠道菌群与结直肠癌关系的研究进展与展望
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Abstract:
结直肠癌是全球范围内最常见的恶性肿瘤之一，其发生发展受到多种遗传和环境因素的影响。近年来，越来越多的研究表明，肠道菌群作为一种重要的环境因素，与结直肠癌的发病机制、临床特征和治疗效果密切相关。肠道菌群可以通过产生代谢物、基因毒素、致炎因子等方式，影响肠道上皮细胞、免疫细胞和肿瘤细胞的功能和相互作用，从而促进或抑制结直肠癌的发生和进展。本文综述了近年来关于肠道菌群与结直肠癌关系的研究进展，重点介绍了肠道菌群在结直肠癌发展及治疗中的作用，并对未来的研究方向和挑战进行了展望。
Colorectal cancer is one of the most common malignant tumors worldwide, and its occurrence and development are influenced by various genetic and environmental factors. In recent years, an increasing number of studies have shown that the gut microbiota, as an important environmental factor, is closely related to the pathogenesis, clinical features, and treatment outcomes of colorectal cancer. The gut microbiota can affect the functions and interactions of intestinal epithelial cells, immune cells, and tumor cells through the production of metabolites, genotoxins, and pro-inflammatory factors, thereby promoting or inhibiting the occurrence and progression of colorectal cancer. This article reviews the research progress on the relationship between the gut microbiota and colorectal cancer in recent years, focusing on the role of the gut microbiota in the development and treatment of colorectal cancer, and looks forward to future research directions and challenges.
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