Introduction: Pain has been defined for more than 20 years by the International Association for the Study of Pain (IASP) as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. It has been recognized as a feature of Parkinson’s disease (PD) since the first descriptions of the disease. Material and Methods: This was a prospective descriptive study lasting six (06) months from November 1, 2023 to April 30, 2024. We included all patients diagnosed with PD and who had pain. Sociodemographic, clinical, paraclinical and therapeutic data were evaluated for each patient. Results: We identified a sample of 62 Parkinson’s patients, of whom 52 patients or 85.2% had associated pain. We noted a male predominance (38M/14F) and a sex ratio of 2.71. Musculoskeletal pain was common in 80% of our respondents. WHO level I, antidepressants and background treatment for KD were the most prescribed molecules. Conclusion: Our study shows a frequency of pain in PD. However, musculoskeletal pain is the most frequently encountered type of pain in PD patients. WHO step I analgesics, antidepressants and background treatment of KD were the main prescriptions in our study.
References
[1]
Raja, S.N., Carr, D.B., Cohen, M., Finnerup, N.B., Flor, H., Gibson, S., et al. (2020) The Revised International Association for the Study of Pain Definition of Pain: Concepts, Challenges, and Compromises. Pain, 161, 1976-1982. https://doi.org/10.1097/j.pain.0000000000001939
[2]
Ford, B. (2010) Pain in Parkinson’s disease: Pain in Parkinson’s Disease. Movement Disorders, 25, S98-S103.
[3]
Hirsi, J.O., Yifru, Y.M., Metaferia, G.Z. and Bower, J.H. (2019) Prevalence of Pain in Patients with Parkinson’s Disease in Addis Ababa, Ethiopia. Parkinsonism & Related Disorders, 61, 214-218. https://doi.org/10.1016/j.parkreldis.2018.09.030
[4]
Valkovic, P., Minar, M., Singliarova, H., Harsany, J., Hanakova, M., Martinkova, J., et al. (2015) Pain in Parkinson’s Disease: A Cross-Sectional Study of Its Prevalence, Types, and Relationship to Depression and Quality of Life. PLOS ONE, 10, e0136541. https://doi.org/10.1371/journal.pone.0136541
[5]
Goetz, C.G., Tanner, C.M., Levy, M., Wilson, R.S. and Garron, D.C. (1986) Pain in Parkinson’s Disease. Movement Disorders, 1, 45-49. https://doi.org/10.1002/mds.870010106
[6]
Lin, X., Yu, N., Lin, X., Zhang, Y., Chen, Y., Zhang, K., et al. (2016) A Clinical Survey of Pain in Parkinson’s Disease in Eastern China. International Psychogeriatrics, 28, 283-289. https://doi.org/10.1017/s1041610215001659
[7]
Tibar, H., El Bayad, K., Bouhouche, A., Ait Ben Haddou, E.H., Benomar, A., Yahyaoui, M., et al. (2018) Non-motor Symptoms of Parkinson’s Disease and Their Impact on Quality of Life in a Cohort of Moroccan Patients. Frontiers in Neurology, 9, Article 170. https://doi.org/10.3389/fneur.2018.00170
[8]
Maïga, B., Koné, A., Landouré, G., Coulibaly, T., Sangaré, M., Dembélé, K., et al. (2016) Non-Motor Signs in Patients with Parkinson’s Disease at the University Hospital of Point “G”, Mali. eNeurologicalSci, 3, 35-36. https://doi.org/10.1016/j.ensci.2016.02.001
[9]
Wasner, G. and Deuschl, G. (2012) Pains in Parkinson Disease—Many Syndromes under One Umbrella. Nature Reviews Neurology, 8, 284-294. https://doi.org/10.1038/nrneurol.2012.54
[10]
Silverdale, M.A., Kobylecki, C., Kass-Iliyya, L., Martinez-Martin, P., Lawton, M., Cotterill, S., et al. (2018) A Detailed Clinical Study of Pain in 1957 Participants with Early/moderate Parkinson’s Disease. Parkinsonism & Related Disorders, 56, 27-32. https://doi.org/10.1016/j.parkreldis.2018.06.001
[11]
Fu, Y., Mao, C., Ma, L., Zhang, H., Wang, Y., Li, J., et al. (2017) Pain Correlates with Sleep Disturbances in Parkinson’s Disease Patients. Pain Practice, 18, 29-37. https://doi.org/10.1111/papr.12578
[12]
Fekih, M.E., Bedoui, I., Bissene, D., Zaouali, J., Hajer, D., Ridha, M., et al. (2021) Syndrome douloureux de la maladie de Parkinson. Revue Neurologique, 177, S21. https://doi.org/10.1016/j.neurol.2021.02.125
[13]
Etchepare, F., Rozenberg, S., Mirault, T., Bonnet, A., Lecorre, C., Agid, Y., et al. (2006) Back Problems in Parkinson’s Disease: An Underestimated Problem. Joint Bone Spine, 73, 298-302. https://doi.org/10.1016/j.jbspin.2005.05.006
[14]
Buhmann, C., Wrobel, N., Grashorn, W., Fruendt, O., Wesemann, K., Diedrich, S., et al. (2017) Pain in Parkinson Disease: A Cross-Sectional Survey of Its Prevalence, Specifics, and Therapy. Journal of Neurology, 264, 758-769. https://doi.org/10.1007/s00415-017-8426-y
[15]
Layouni, S., Elmatwa, S., Jemni, S., Mariem, G., Khachnaoui, F., Ouannes, W., et al. (2019) La Maladie de Parkinson Idiopathique: Troubles morpho-statiques et fonctionnels du pied. Revue Neurologique, 175, S109. https://doi.org/10.1016/j.neurol.2019.01.289
[16]
Miller, I.N. and Cronin‐Golomb, A. (2010) Gender Differences in Parkinson’s Disease: Clinical Characteristics and Cognition. Movement Disorders, 25, 2695-2703. https://doi.org/10.1002/mds.23388
[17]
Yoritaka, A., Shimo, Y., Takanashi, M., Fukae, J., Hatano, T., Nakahara, T., et al. (2013) Motor and Non-Motor Symptoms of 1453 Patients with Parkinson’s Disease: Prevalence and Risks. Parkinsonism & Related Disorders, 19, 725-731. https://doi.org/10.1016/j.parkreldis.2013.04.001
[18]
Giuffrida, R., Vingerhoets, F.J.G., Bogousslavsky, J. and Ghika, J. (2005) Syndromes douloureux de la maladie de Parkinson. Revue Neurologique, 161, 407-418. https://doi.org/10.1016/s0035-3787(05)85070-2
[19]
Bouthouri, A., Salma, N., Hassine, A., Douma, R., Amor, S.B. and Sofiene, B.A. (2017) Douleurs au cours de la maladie de Parkinson: Un problème sous-estimé? Revue Neurologique, 173, S141. https://doi.org/10.1016/j.neurol.2017.01.254
[20]
Mooventhan, A. and Nivethitha, L. (2017) Evidence Based Effects of Yoga Practice on Various Health Related Problems of Elderly People: A Review. Journal of Bodywork and Movement Therapies, 21, 1028-1032. https://doi.org/10.1016/j.jbmt.2017.01.004
[21]
Myers, P.S., Harrison, E.C., Rawson, K.S., Horin, A.P., Sutter, E.N., McNeely, M.E., et al. (2019) Yoga Improves Balance and Low-Back Pain, but Not Anxiety, in People with Parkinson’s Disease. International Journal of Yoga Therapy, 30, 41-48. https://doi.org/10.17761/2020-d-18-00028
[22]
Georgiev, D., Hamberg, K., Hariz, M., Forsgren, L. and Hariz, G. (2017) Gender Differences in Parkinson’s Disease: A Clinical Perspective. Acta Neurologica Scandinavica, 136, 570-584. https://doi.org/10.1111/ane.12796
[23]
Skogar, O. and Lökk, J. (2016) Pain Management in Patients with Parkinson’s Disease: Challenges and Solutions. Journal of Multidisciplinary Healthcare, 9, 469-479. https://doi.org/10.2147/jmdh.s105857