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儿童过敏性鼻炎相关现状及进展
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Abstract:
过敏性鼻炎是一个广泛的全球性健康问题。根据流行病学调查显示，近年来随着空气环境的恶化及人们生活方式的改变，过敏性鼻炎的发病率呈现逐年升高趋势，已成为危害人类健康的社会性问题之一，并且儿童也是过敏性鼻炎的高发人群。儿童过敏性鼻炎主要症状包括鼻塞、鼻痒、流涕和打喷嚏，其发生常表现出病情易反复、迁延不愈等特点，对患儿的生命健康、正常生长、发育状态均有着严重的负面影响。现阶段临床治疗该疾病的方式有健康教育、药物治疗、免疫治疗及辅助治疗。本文将从流行病学、临床特征、过敏原、治疗方式及预防角度对儿童过敏性鼻炎进行阐述。
Allergic rhinitis is a widespread global health issue. According to the epidemiological survey, in recent years, with the deterioration of the air environment and the change of people’s lifestyle, the incidence rate of allergic rhinitis has increased year by year, which has become one of the social problems endangering human health, and children are also the high incidence group of allergic rhinitis. The main symptoms of allergic rhinitis in children include nasal congestion, itching, runny nose, and sneezing. Its occurrence often shows the characteristics of easy recurrence and persistent illness, which has a serious negative impact on the child’s life, health, normal growth, and development status. At present, the clinical treatment methods for this disease include health education, drug therapy, immunotherapy, and adjuvant therapy. This article will elaborate on the epidemiology, clinical characteristics, allergens, treatment methods, and prevention of allergic rhinitis in children.
| [1] | Passali, D., Cingi, C., Staffa, P., Passali, F., Muluk, N.B. and Bellussi, M.L. (2018) The International Study of the Allergic Rhinitis Survey: Outcomes from 4 Geographical Regions. Asia Pacific Allergy, 8, e7. https://doi.org/10.5415/apallergy.2018.8.e7 |
| [2] | 张建基, 时蕾. 《儿童过敏性鼻炎诊疗——临床实践指南》发病机制部分解读[J]. 中国实用儿科杂志, 2019, 34(3): 182-187. |
| [3] | Pfaar, O., Angier, E., Muraro, A., Halken, S. and Roberts, G. (2020) Algorithms in Allergen Immunotherapy in Allergic Rhinoconjunctivitis. Allergy, 75, 2411-2414. https://doi.org/10.1111/all.14270 |
| [4] | Asano, K., Ueki, S., Tamari, M., Imoto, Y., Fujieda, S. and Taniguchi, M. (2020) Adult‐Onset Eosinophilic Airway Diseases. Allergy, 75, 3087-3099. https://doi.org/10.1111/all.14620 |
| [5] | 中华耳鼻咽喉头颈外科杂志编辑委员会鼻科组, 中华医学会耳鼻咽喉头颈外科学分会鼻科学组. 中国变应性鼻炎诊断和治疗指南(2022年, 修订版) [J]. 中华耳鼻咽喉头颈外科杂志, 2022, 57(2): 106-129. |
| [6] | 唐龙, 姜彦. 儿童变应性鼻炎675例临床特征和过敏原分析[J]. 青岛大学学报(医学版), 2022, 58(6): 860-864. |
| [7] | Westman, M., Kull, I., Lind, T., Melén, E., Stjärne, P., Toskala, E., et al. (2013) The Link between Parental Allergy and Offspring Allergic and Nonallergic Rhinitis. Allergy, 68, 1571-1578. https://doi.org/10.1111/all.12267 |
| [8] | 俞雪梅, 高树云. 过敏家族史与婴儿过敏性疾病的关系[J]. 中国血液流变学杂志, 2004, 14(4): 618-623. |
| [9] | 乔宏颖, 董蕊, 陈宏伟, 等. 变应性鼻炎和变应性哮喘危险因素调查分析[J]. 河北医药, 2014, 36(2): 274-276. |
| [10] | García-Almaraz, R., Reyes-Noriega, N., Del-Río-Navarro, B.E., Berber, A., Navarrete-Rodríguez, E.M., Ellwood, P., et al. (2021) Prevalence and Risk Factors Associated with Allergic Rhinitis in Mexican School Children: Global Asthma Network Phase I. World Allergy Organization Journal, 14, Article ID: 100492. https://doi.org/10.1016/j.waojou.2020.100492 |
| [11] | Wang, R.K., Liang, J.Q., Han, W., et al. (2022) Prevalence of Allergic Rhinitis in Chinese Children from 2001 to 2021: Meta-Analysis. Chinese Journal of Preventive Medicine, 56, 784-793. |
| [12] | 王睿坤, 梁洁琼, 韩伟, 等. 2001-2021年中国儿童青少年过敏性鼻炎患病率的Meta分析[J]. 中华预防医学杂志, 2022, 56(6): 784-793. |
| [13] | Bylund, S., Kobyletzki, L., Svalstedt, M. and Svensson, M. (2020) Prevalence and Incidence of Atopic Dermatitis: A Systematic Review. Acta Dermato Venereologica, 100, adv00160. https://doi.org/10.2340/00015555-3510 |
| [14] | Langan, S.M., Irvine, A.D. and Weidinger, S. (2020) Atopic Dermatitis. The Lancet, 396, 345-360. https://doi.org/10.1016/s0140-6736(20)31286-1 |
| [15] | 沈翎, 杨中婕, 林宗通, 林兴. 《儿童过敏性鼻炎诊疗——临床实践指南》诊断部分解读[J]. 中国实用儿科杂志, 2019, 34(3): 188-191. |
| [16] | Otolaryngology Professional Committee, Pediatrician Branch, Chinese Medical Doctor Association. 儿童过敏性鼻炎诊疗——临床实践指南[J]. 中国实用儿科杂志, 2019, 34(3): 169-175. |
| [17] | 余斐斐, 骆婷婷, 王荣军, 等. 866例儿童过敏性鼻炎过敏原分析[J]. 中国卫生检验杂志, 2021, 31(4): 502-507. |
| [18] | 张伟, 赵岩, 王成硕, 等. 过敏性鼻炎患者伴发食物过敏原致敏状 态分析[J]. 首都医科大学学报, 2011, 32(1): 8-12. |
| [19] | Drazdauskaitė, G., Layhadi, J.A. and Shamji, M.H. (2020) Mechanisms of Allergen Immunotherapy in Allergic Rhinitis. Current Allergy and Asthma Reports, 21, Article No. 2. https://doi.org/10.1007/s11882-020-00977-7 |
| [20] | Bousquet, J., Khaltaev, N., Cruz, A.A., Denburg, J., Fokkens, W.J., Togias, A., et al. (2008) Allergic Rhinitis and Its Impact on Asthma (ARIA) 2008. Allergy, 63, 8-160. https://doi.org/10.1111/j.1398-9995.2007.01620.x |
| [21] | Brożek, J.L., Bousquet, J., Agache, I., Agarwal, A., Bachert, C., Bosnic-Anticevich, S., et al. (2017) Allergic Rhinitis and Its Impact on Asthma (ARIA) Guidelines—2016 Revision. Journal of Allergy and Clinical Immunology, 140, 950-958. https://doi.org/10.1016/j.jaci.2017.03.050 |
| [22] | 李琪, 张云飞, 许政敏. 复旦大学附属儿科医院2413例过敏性鼻炎患儿过敏原筛查结果分析[J]. 中国实用儿科杂志, 2019, 34(3): 209-211. |
| [23] | 郑欣欣, 林榆, 杨婷婷. 福州地区642例儿童过敏性鼻炎过敏原检测结果分析[J]. 福建医药杂志, 2017, 39(5): 123-125. |
| [24] | 王惠妩, 徐佩茹, 向阳冰, 等. 新疆地区过敏性鼻炎患儿过敏原检测分析[J]. 临床儿科杂志, 2007, 25(1): 30-32. |
| [25] | 阳玉萍, 王燕, 谭国萍, 等. 新疆地区儿童变应性鼻炎变应原分类及分布情况的分析[J]. 中国妇幼保健, 2016, 31(7): 1424-1426. |
| [26] | 马婷婷, 王洪田, 陈艳蕾, 等. 北京地区门诊患者常见吸入过敏原致敏谱[J]. 中华临床免疫和变态反应杂志, 2021, 15(2): 136-143. |
| [27] | 胡慧敏, 张媛, 黄东生, 谷易轩, 朱霞, 张伟令, 张谊, 徐琛. 儿童过敏性鼻炎伴食物过敏原检测阳性的临床特征分析[J]. 中国医刊, 2024, 59(9): 982-985. |
| [28] | 孙凤卫, 周含, 张立松. 北京地区儿童过敏性鼻炎过敏原筛查结果分析[J]. 中国耳鼻咽喉头颈外科, 2023, 30(11): 719-722. |
| [29] | 汪丽娟. 糠酸莫米松鼻喷剂与西替利嗪滴剂治疗儿童季节性过敏性鼻炎的临床疗效[J]. 基层医学论坛, 2024, 28(7): 10-12+18. |
| [30] | 李慧, 聂雷, 张佩瑶, 刘煜, 高士培. 孟鲁司特钠联合丙酸氟替卡松鼻喷雾剂治疗儿童过敏性鼻炎的效果[J]. 西北药学杂志, 2024, 39(3): 144-148. |
| [31] | 洪铭沿, 郑天文. 儿童过敏性鼻炎舌下免疫治疗的长期疗效及其影响因素分析[J]. 中国医药指南, 2023, 21(35): 1-4. |
| [32] | Jutel, M., Agache, I., Bonini, S., Burks, A.W., Calderon, M., Canonica, W., et al. (2015) International Consensus on Allergy Immunotherapy. Journal of Allergy and Clinical Immunology, 136, 556-568. https://doi.org/10.1016/j.jaci.2015.04.047 |
| [33] | 梁巧. 儿童过敏性鼻炎及皮下免疫治疗前后的血清代谢组学研究[D]: [硕士学位论文] 广州: 南方医科大学儿科学院, 2024. |
| [34] | 朱丹琛, 冯彦, 王斌全. 血清维生素D和IL⁃33/ST2水平与变应性鼻炎关系的研究进展[J]. 临床耳鼻咽喉头颈外科杂志, 2019, 33(9): 898⁃900. |
| [35] | 余滨彬, 邵磊. 变应原特异性免疫疗法治疗儿童过敏性鼻炎合并哮喘的效果及机制研究[J]. 中国妇幼保健, 2024, 39(14): 2615-2618. |
| [36] | 曹文慧, 高英英, 黄亦男. 舌下含服粉尘螨滴剂治疗儿童螨过敏性鼻炎疗效及对血清IL-33、sST2、ILC2水平的影响[J]. 分子诊断与治疗杂志, 2023, 15(11): 2029-2032. |
| [37] | Masuyama, K., Okamoto, Y., Okamiya, K., Azuma, R., Fujinami, T., Riis, B., et al. (2018) Efficacy and Safety of sq House Dust Mite Sublingual Immunotherapy‐Tablet in Japanese Children. Allergy, 73, 2352-2363. https://doi.org/10.1111/all.13544 |
| [38] | 毕淑芳, 倪陈. 鼻腔冲洗联合药物治疗鼻炎及哮喘的临床分析[J]. 临床医药文献电子杂志, 2020, 7(42): 61-62. |
| [39] | 汤小荣, 李知行, 旷徐, 等. 穴位贴敷鼻敏通能量贴治疗过敏性鼻炎的疗效观察[J]. 广州中医药大学学报, 2021, 38(3): 524-530. |
| [40] | Stewart, C.J., Marrs, E.C.L., Nelson, A., Lanyon, C., Perry, J.D., Embleton, N.D., et al. (2013) Development of the Preterm Gut Microbiome in Twins at Risk of Necrotising Enterocolitis and Sepsis. PLOS ONE, 8, e73465. https://doi.org/10.1371/journal.pone.0073465 |
| [41] | Cassir, N., Simeoni, U. and La Scola, B. (2016) Gut Microbiota and the Pathogenesis of Necrotizing Enterocolitis in Preterm Neonates. Future Microbiology, 11, 273-292. https://doi.org/10.2217/fmb.15.136 |
| [42] | 折宁宁, 邵娜, 夏翠, 冯雅妮, 张一彤, 刘海琴, 任晓勇. 维生素D与儿童变应性鼻炎发生风险的Meta分析[J]. 中国儿童保健杂志, 2020, 28(11): 1234-1238. |
