全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Applications and Research Progress of Multifunctional Hydrogels in Periodontal Tissue Regeneration

DOI: 10.4236/jbm.2025.132009, PP. 107-121

Keywords: Hydrogel, Periodontal Tissue Regeneration, Scaffold Material, Bone Defect Repair

Full-Text   Cite this paper   Add to My Lib

Abstract:

Hydrogels, as a novel class of biomaterials, exhibit broad application prospects and are widely used in tissue engineering. In the field of periodontology within dental medicine, hydrogels can be employed for periodontal tissue regeneration to repair the damage caused by periodontitis. At present, various hydrogels have been developed to control periodontal inflammation and repair periodontal tissues. This article, based on domestic and international literature, provides a brief review of hydrogels used in periodontal tissue regeneration.

References

[1]  Meng, H.X. (2008) Periodontology. People’s Medical Publishing House.
[2]  WICHTERLE, O. and LÍM, D. (1960) Hydrophilic Gels for Biological Use. Nature, 185, 117-118.
https://doi.org/10.1038/185117a0
[3]  Kopecek, J. (2009) Hydrogels: From Soft Contact Lenses and Implants to Self‐assembled Nanomaterials. Journal of Polymer Science Part A: Polymer Chemistry, 47, 5929-5946.
https://doi.org/10.1002/pola.23607
[4]  Sharma, S. and Tiwari, S. (2020) RETRACTED: A Review on Biomacromolecular Hydrogel Classification and Its Applications. International Journal of Biological Macromolecules, 162, 737-747.
https://doi.org/10.1016/j.ijbiomac.2020.06.110
[5]  Zang, S., Mu, R., Chen, F., Wei, X., Zhu, L., Han, B., et al. (2019) Injectable Chitosan/β-Glycerophosphate Hydrogels with Sustained Release of BMP-7 and Ornidazole in Periodontal Wound Healing of Class III Furcation Defects. Materials Science and Engineering: C, 99, 919-928.
https://doi.org/10.1016/j.msec.2019.02.024
[6]  Fu, J. and in het Panhuis, M. (2019) Hydrogel Properties and Applications. Journal of Materials Chemistry B, 7, 1523-1525.
https://doi.org/10.1039/c9tb90023c
[7]  Batool, F., Strub, M., Petit, C., Bugueno, I.M., Bornert, F., Clauss, F., et al. (2018) Periodontal Tissues, Maxillary Jaw Bone, and Tooth Regeneration Approaches: From Animal Models Analyses to Clinical Applications. Nanomaterials, 8, Article 337.
https://doi.org/10.3390/nano8050337
[8]  Lee, H., Byun, S., Cho, S. and Yang, B. (2019) Past, Present, and Future of Regeneration Therapy in Oral and Periodontal Tissue: A Review. Applied Sciences, 9, Article 1046.
https://doi.org/10.3390/app9061046
[9]  Yan, F.H., & Li, L.L. (2018) Advances in Periodontal Regenerative Therapy. Journal of Oral Medicine Research, 34, 217-222.
[10]  Zhou, T., Zheng, K., Sui, B., Boccaccini, A.R. and Sun, J. (2020) In Vitro Evaluation of Poly (Vinyl Alcohol)/Collagen Blended Hydrogels for Regulating Human Periodontal Ligament Fibroblasts and Gingival Fibroblasts. International Journal of Biological Macromolecules, 163, 1938-1946.
https://doi.org/10.1016/j.ijbiomac.2020.09.033
[11]  Song, Y., Zhang, C., Wang, P., Wang, L., Bao, C., Weir, M.D., et al. (2017) Engineering Bone Regeneration with Novel Cell-Laden Hydrogel Microfiber-Injectable Calcium Phosphate Scaffold. Materials Science and Engineering: C, 75, 895-905.
https://doi.org/10.1016/j.msec.2017.02.158
[12]  Koch, F., Ekat, K., Kilian, D., Hettich, T., Germershaus, O., Lang, H., et al. (2019) A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling Peptides with Antimicrobial and Regenerative Potential. Advanced Healthcare Materials, 8, Article ID: 1900167.
https://doi.org/10.1002/adhm.201900167
[13]  Liu, S., Wang, Y., Yu, L., Li, J. and Ge, S. (2022) Development of a Thermosensitive Hydrogel Loaded with DTT and SDF-1 Facilitating in Situ Periodontal Bone Regeneration. Chemical Engineering Journal, 432, Article ID: 134308.
https://doi.org/10.1016/j.cej.2021.134308
[14]  Wang, Y., Yao, Z.A. and Wu, H.G. (2022) Research Progress of Chitosan Thermosen-sitive Hydrogels in Bone Tissue Engineering. New Chemical Materials, 50, 13-19.
[15]  Chen, X., Ren, C.X., Liu, L.L., et al. (2020) Study on Injectable Thermosensitive Hydrogel Loaded with Tacrolimus for Promoting Periodontal Tissue Regeneration. Journal of Oral and Maxillofacial Surgery, 30, 272-278.
[16]  Wang, H., Chang, X., Ma, Q., Sun, B., Li, H., Zhou, J., et al. (2023) Bioinspired Drug-Delivery System Emulating the Natural Bone Healing Cascade for Diabetic Periodontal Bone Regeneration. Bioactive Materials, 21, 324-339.
https://doi.org/10.1016/j.bioactmat.2022.08.029
[17]  Liu, Y.P., Kuang, P.P., Chen, Y., et al. (2022) Research Progress of Biomass-Based Stimuli-Responsive Hydrogels. Chemistry and Industry of Forest Products, 42, 126-134.
[18]  Bako, J., Toth, F., Gall, J., Kovacs, R., Csík, A., Varga, I., et al. (2022) Combined Release of Antiseptic and Antibiotic Drugs from Visible Light Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment. Pharmaceutics, 14, Article 957.
https://doi.org/10.3390/pharmaceutics14050957
[19]  Yu, M., Chang, C., Chao, Y., Jheng, Y., Yang, C., Lee, N., et al. (2016) Ph-Responsive Hydrogel with an Anti‐glycation Agent for Modulating Experimental Periodontitis. Journal of Periodontology, 87, 742-748.
https://doi.org/10.1902/jop.2016.150542
[20]  Lin, J.H., Feng, F., Yu, M.C., Wang, C. and Chang, P. (2017) Modulation of Periodontitis Progression Using ph‐responsive Nanosphere Encapsulating Metronidazole or n-Phenacylthialzolium Bromide. Journal of Periodontal Research, 53, 22-28.
https://doi.org/10.1111/jre.12481
[21]  Li, Y., Zhang, L., Song, Z., Li, F. and Xie, D. (2022) Intelligent Temperature-Ph Dual Responsive Nanocellulose Hydrogels and the Application of Drug Release towards 5-fluorouracil. International Journal of Biological Macromolecules, 223, 11-16.
https://doi.org/10.1016/j.ijbiomac.2022.10.188
[22]  Ma, Y., Ji, Y., Zhong, T., Wan, W., Yang, Q., Li, A., et al. (2017) Bioprinting-based PDLSC-ECM Screening for in Vivo Repair of Alveolar Bone Defect Using Cell-Laden, Injectable and Photocrosslinkable Hydrogels. ACS Biomaterials Science & Engineering, 3, 3534-3545.
https://doi.org/10.1021/acsbiomaterials.7b00601
[23]  Goto, R., Nishida, E., Kobayashi, S., Aino, M., Ohno, T., Iwamura, Y., et al. (2021) Gelatin Methacryloyl-Riboflavin (GelMA-RF) Hydrogels for Bone Regeneration. International Journal of Molecular Sciences, 22, Article 1635.
https://doi.org/10.3390/ijms22041635
[24]  Wei, Y., Wang, Z., Han, J., Jiang, X., Lei, L., Yang, X., et al. (2022) Modularized Bioceramic Scaffold/Hydrogel Membrane Hierarchical Architecture Beneficial for Periodontal Tissue Regeneration in Dogs. Biomaterials Research, 26, Article 68.
https://doi.org/10.1186/s40824-022-00315-0
[25]  Liu, J.Y., Xiao, Y., Wang, X.Y., et al. (2020) Experimental Study of Glucose-Sensitive Hydrogels for Treating Periodontitis in Diabetic Rats. Journal of Oral Medicine Research, 36, 567-571.
[26]  Mahinroosta, M., Jomeh Farsangi, Z., Allahverdi, A. and Shakoori, Z. (2018) Hydrogels as Intelligent Materials: A Brief Review of Synthesis, Properties and Applications. Materials Today Chemistry, 8, 42-55.
https://doi.org/10.1016/j.mtchem.2018.02.004
[27]  Guo, J., Sun, H., Lei, W., Tang, Y., Hong, S., Yang, H., et al. (2019) Mmp-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery. Journal of Dental Research, 98, 564-571.
https://doi.org/10.1177/0022034519831931
[28]  Liu, S., Wang, Y., Ma, B., Shao, J., Liu, H. and Ge, S. (2021) Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates in Situ Periodontal Tissue Regeneration. ACS Applied Materials & Interfaces, 13, 36880-36893.
https://doi.org/10.1021/acsami.1c08855
[29]  Koch, F., Wolff, A., Mathes, S., Pieles, U., Saxer, S., Kreikemeyer, B., et al. (2018) Amino Acid Composition of Nanofibrillar Self-Assembling Peptide Hydrogels Affects Responses of Periodontal Tissue Cells in Vitro. International Journal of Nanomedicine, 13, 6717-6733.
https://doi.org/10.2147/ijn.s173702
[30]  Xu, W., Tan, W., Li, C., Wu, K., Zeng, X. and Xiao, L. (2021) Metformin-Loaded β-TCP/CTS/SBA-15 Composite Scaffolds Promote Alveolar Bone Regeneration in a Rat Model of Periodontitis. Journal of Materials Science: Materials in Medicine, 32, Article No. 145.
https://doi.org/10.1007/s10856-021-06621-8
[31]  dos Santos, D.M., Moon, J., Kim, D., Bassous, N.J., Marangon, C.A., Campana-Filho, S.P., et al. (2024) Hierarchical Chitin Nanocrystal-Based 3D Printed Dual-Layer Membranes Hydrogels: A Dual Drug Delivery Nano-Platform for Periodontal Tissue Regeneration. ACS Nano, 18, 24182-24203.
https://doi.org/10.1021/acsnano.4c05558
[32]  Hu, C., Zhang, M., Wu, J., Cao, X., Chen, L., Yan, J., et al. (2023) Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition. ACS Applied Materials & Interfaces, 15, 9066-9079.
https://doi.org/10.1021/acsami.2c21297
[33]  Dubey, N., Ferreira, J.A., Daghrery, A., Aytac, Z., Malda, J., Bhaduri, S.B., et al. (2020) Highly Tunable Bioactive Fiber-Reinforced Hydrogel for Guided Bone Regeneration. Acta Biomaterialia, 113, 164-176.
https://doi.org/10.1016/j.actbio.2020.06.011
[34]  Liu, X., He, X., Jin, D., Wu, S., Wang, H., Yin, M., et al. (2020) A biodegradable Multifunctional Nanofibrous Membrane for Periodontal Tissue Regeneration. Acta Biomaterialia, 108, 207-222.
https://doi.org/10.1016/j.actbio.2020.03.044
[35]  Peng, C., Wang, G., Li, J., Wang, Y., Shu, Z., Tang, M., et al. (2024) Ros-Responsive and Scavenging Bifunctional Hydrogel Enables Co-Delivery of Anti-Inflammatory Agent and Osteogenetic Nanoparticle for Periodontitis Treatment. Materials & Design, 239, Article ID: 112777.
https://doi.org/10.1016/j.matdes.2024.112777
[36]  Tang, M., Li, J., Wang, G., Wang, Y., Peng, C., Chang, X., et al. (2024) Cubic Liquid Crystals Containing Propolis Flavonoids as in Situ Thermo-Sensitive Hydrogel Depots for Periodontitis Treatment: Preparation, Pharmacodynamics and Therapeutic Mechanisms. European Journal of Pharmaceutical Sciences, 196, Article ID: 106762.
https://doi.org/10.1016/j.ejps.2024.106762
[37]  Pham, D.T., Phewchan, P., Navesit, K., Chokamonsirikun, A., Khemwong, T. and Tiyaboonchai, W. (2021) Development of Metronidazole-Loaded in Situ Thermosensitive Hydrogel for Periodontitis Treatment. Turkish Journal of Pharmaceutical Sciences, 18, 510-516.
https://doi.org/10.4274/tjps.galenos.2020.09623
[38]  Xu, S., Hu, B., Dong, T., Chen, B., Xiong, X., Du, L., et al. (2023) Alleviate Periodontitis and Its Comorbidity Hypertension Using a Nanoparticle-Embedded Functional Hydrogel System. Advanced Healthcare Materials, 12, Article ID: 2203337.
https://doi.org/10.1002/adhm.202203337
[39]  Tan, J., Zhang, M., Hai, Z., Wu, C., Lin, J., Kuang, W., et al. (2019) Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano, 13, 5616-5622.
https://doi.org/10.1021/acsnano.9b00788
[40]  Zhang, W., Wang, X., Wang, S., Zhao, J., Xu, L., Zhu, C., et al. (2011) The Use of Injectable Sonication-Induced Silk Hydrogel for VEGF165 and BMP-2 Delivery for Elevation of the Maxillary Sinus Floor. Biomaterials, 32, 9415-9424.
https://doi.org/10.1016/j.biomaterials.2011.08.047

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133