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Medical Diagnosis 2025
SIRT1调节生长过程的研究进展
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Abstract:
儿童生长过程的调节取决于生长激素(Growth Hormone, GH)和胰岛素样生长因子1 (Insulin-Like Growth Factor 1, IGF-1)的作用，其中IGF-1是GH活性的主要介质。最近，有众多学者报道了可能有助于调节GH以及IGF-1分泌的新因素，其中之一是沉默信息调节因子1 (Silent Information Regulator 1, SIRT1)。SIRT1可通过负向调节JAK2/STAT通路，参与肝细胞中GH信号的转导，抑制IGF-1 mRNA的产生。此外，它还参与下丘脑中生长激素释放激素和生长细胞中GH合成的调节。SIRT1被认为参与生长板软骨发育和纵向骨生长，对骨骺生长板有积极影响。此外，也有研究表明SIRT1在宫内生长受限、小于胎龄儿、矮小症方面有重要意义。文章将详细阐述SIRT1可能对儿童生长过程产生的影响。
The regulation of the growth process in children depends on the action of Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1), of which IGF-1 is the main mediator of GH activity. Recently, many scholars have reported a new factor that may help to regulate the secretion of GH and IGF-1, one of which is Silent Information Regulator 1 (SIRT1). SIRT1 can negatively regulate the JAK2/STAT pathway, participate in the transduction of GH signal in hepatocytes, and inhibit the production of IGF-1 mRNA. In addition, it is involved in the regulation of GH-releasing hormone in the hypothalamus and GH synthesis in growth cells. SIRT1 is thought to be involved in growth plate chondrogenesis and longitudinal bone growth, with a positive effect on the epiphyseal growth plate. In addition, some studies have shown that SIRT1 plays an important role in intrauterine growth restriction, small for gestational age, and short stature. This article will elaborate on the possible effects of SIRT1 on the growth of children.
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