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中性粒细胞胞外陷阱与脓毒症关系的全球热点研究与趋势：2004~2024年文献计量分析
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Abstract:
Objective: To investigate the relationship between neutrophil extracellular traps (NETs) and sepsis, which can help elucidate the specific molecular mechanisms of sepsis. The causal link between NETs and sepsis progression has been extensively validated. However, few articles have utilized bibliometric methods to analyze research in this field. Therefore, this paper analyzes the research hotspots and trends in NETs and sepsis over the past two decades from a bibliometric perspective, aiming to provide new insights into the fundamentals and research in this field. Methods: We collected publications related to neutrophil extracellular traps (NETs) in the field of sepsis from 2004 to 2024 from the Web of Science Core Collection. Publications were limited to articles and reviews, and the language was restricted to English. VOSviewer and COOC software were used to conduct bibliometric and knowledge map analysis of research collaboration networks, journals, cited references, and keywords in this field. Results: From 2004 to 2024, the Web of Science Core Collection included 720 articles on NETs and sepsis research, including 452 articles and 226 reviews. Since 2022, the number of articles in this field has rapidly increased. The United States and China are the primary contributors in this field. Articles on this topic have been published in 294 academic journals. The author with the most publications is Liaw Patricia C., and Frontiers in Immunology is the most cited journal. In addition to “sepsis” and “neutrophil extracellular traps,” high-frequency terms in the keyword co-occurrence network analysis include inflammation, neutrophils, platelets, thrombosis, Covid-19, infection, innate immunity, and septic shock. An analysis of keyword trends using the burst test indicates that thrombosis and ARDS are currently at the forefront of research in this field. ARDS is currently a hot topic regarding the related roles and potential mechanisms of NETs and sepsis in this field. Conclusion: This study provides a bibliometric analysis and visualization of key research areas in sepsis and NETs over the past 20 years. The results indicate that thrombosis and ARDS are currently hot topics regarding the related roles and potential mechanisms of NETs and sepsis in this field.
| [1] | Bone, R.C., Balk, R.A., Cerra, F.B., Dellinger, R.P., Fein, A.M., Knaus, W.A., et al. (1992) Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis. Chest, 101, 1644-1655. https://doi.org/10.1378/chest.101.6.1644 |
| [2] | Seymour, C.W., Liu, V.X., Iwashyna, T.J., Brunkhorst, F.M., Rea, T.D., Scherag, A., et al. (2016) Assessment of Clinical Criteria for Sepsis. Journal of the American Medical Association, 315, 762-774. https://doi.org/10.1001/jama.2016.0288 |
| [3] | Iba, T., Umemura, Y., Watanabe, E., Wada, T., Hayashida, K. and Kushimoto, S. (2019) Diagnosis of Sepsis-Induced Disseminated Intravascular Coagulation and Coagulopathy. Acute Medicine & Surgery, 6, 223-232. https://doi.org/10.1002/ams2.411 |
| [4] | Rudd, K.E., Johnson, S.C., Agesa, K.M., Shackelford, K.A., Tsoi, D., Kievlan, D.R., et al. (2020) Global, Regional, and National Sepsis Incidence and Mortality, 1990-2017: Analysis for the Global Burden of Disease Study. The Lancet, 395, 200-211. https://doi.org/10.1016/s0140-6736(19)32989-7 |
| [5] | Kaplan, M.J. and Radic, M. (2012) Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity. The Journal of Immunology, 189, 2689-2695. https://doi.org/10.4049/jimmunol.1201719 |
| [6] | Thompson, D.F. and Walker, C.K. (2015) A Descriptive and Historical Review of Bibliometrics with Applications to Medical Sciences. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 35, 551-559. https://doi.org/10.1002/phar.1586 |
| [7] | van Eck, N.J. and Waltman, L. (2009) Software Survey: Vosviewer, a Computer Program for Bibliometric Mapping. Scientometrics, 84, 523-538. https://doi.org/10.1007/s11192-009-0146-3 |
| [8] | Xue Shu Dian Di (2021) COOC Is a Software for Bibliometrics and Knowledge Graph Drawing. https://github.com/2088904822 |
| [9] | Hottz, E.D., Lopes, J.F., Freitas, C., Valls-de-Souza, R., Oliveira, M.F., Bozza, M.T., et al. (2013) Platelets Mediate Increased Endothelium Permeability in Dengue through NLRP3-Inflammasome Activation. Blood, 122, 3405-3414. https://doi.org/10.1182/blood-2013-05-504449 |
| [10] | Clark, S.R., Ma, A.C., Tavener, S.A., McDonald, B., Goodarzi, Z., Kelly, M.M., et al. (2007) Platelet TLR4 Activates Neutrophil Extracellular Traps to Ensnare Bacteria in Septic Blood. Nature Medicine, 13, 463-469. https://doi.org/10.1038/nm1565 |
| [11] | Yousefi, S., Gold, J.A., Andina, N., Lee, J.J., Kelly, A.M., Kozlowski, E., et al. (2008) Catapult-Like Release of Mitochondrial DNA by Eosinophils Contributes to Antibacterial Defense. Nature Medicine, 14, 949-953. https://doi.org/10.1038/nm.1855 |
| [12] | Phillipson, M. and Kubes, P. (2011) The Neutrophil in Vascular Inflammation. Nature Medicine, 17, 1381-1390. https://doi.org/10.1038/nm.2514 |
| [13] | Hakkim, A., Fuchs, T.A., Martinez, N.E., Hess, S., Prinz, H., Zychlinsky, A., et al. (2010) Activation of the Raf-MEK-ERK Pathway Is Required for Neutrophil Extracellular Trap Formation. Nature Chemical Biology, 7, 75-77. https://doi.org/10.1038/nchembio.496 |
| [14] | Matthay, M.A., Ware, L.B. and Zimmerman, G.A. (2012) The Acute Respiratory Distress Syndrome. Journal of Clinical Investigation, 122, 2731-2740. https://doi.org/10.1172/jci60331 |
| [15] | McDonald, B., Urrutia, R., Yipp, B.G., Jenne, C.N. and Kubes, P. (2012) Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis. Cell Host & Microbe, 12, 324-333. https://doi.org/10.1016/j.chom.2012.06.011 |
| [16] | Gammoh, N. and Rink, L. (2017) Zinc in Infection and Inflammation. Nutrients, 9, Article 624. https://doi.org/10.3390/nu906062 |
