刘松山教授治疗儿童再生障碍性贫血用药组方规律探寻
Exploration of Professor Liu Songshan’s Prescription Rules in the Treatment of Aplastic Anemia in Children

目的：基于数据挖掘探讨刘松山教授治疗儿童再生障碍性贫血的用药规律。方法：收集2023年10月~2024年10月于成都中医药大学附属医院血液科门诊治疗的再生障碍性贫血患儿。使用古今医案云平台软件对药物的频次、药物属性、关联药物、聚类分析等进行分析。结果：150首处方共涉及129味中药，排名前10位的药物分别是黄芪、熟地黄、菟丝子、巴戟天、续断、白术、生地黄、赤芍、补骨脂、牡丹皮，药性以温、寒、平性最多，药味以甘、苦为主，归经以肝、肾、脾为主，重要药对为黄芪–熟地黄。聚类分析获得核心药物组合2组。结论：刘松山教授治疗儿童再生障碍性贫血以健脾补肾、益精填髓为主，先后天同治，兼清热、凉血、理气，着重恢复骨髓化生气血的生理功能。
Objective: To explore the medication rules of Professor Liu Songshan in the treatment of aplastic anemia in children based on data mining. Methods: Children with aplastic anemia who were treated in the Department of Hematology, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine from October 2023 to October 2024 were collected. The ancient and modern medical case cloud platform software was used to analyze the frequency, drug properties, related drugs, and cluster analysis of drugs. Results: A total of 129 traditional Chinese medicines were involved in 150 prescriptions. The top 10 drugs were Astragalus, Rehmanniae Radix Praeparata, Cuscuta chinensis, Morinda officinalis, Dipsacus, Atractylodes macrocephala, Rehmanniae Radix Praeparata, Paeoniae Radix Rubra, Psoralea corylifolia and Cortex Moutan. The medicinal properties were mostly warm, cold and flat. The flavors were mainly sweet and bitter. The meridians were mainly liver, kidney and spleen. The important drug pair was Astragalus-Rehmanniae Radix Praeparata. Cluster analysis obtained two groups of core drug combinations. Conclusion: Professor Liu Songshan’s treatment of aplastic anemia in children is mainly based on invigorating spleen and kidney, benefiting essence and filling marrow. He has been treated with the same treatment, and has the functions of clearing heat, cooling blood and regulating qi, focusing on restoring the physiological function of bone marrow transforming into qi and blood.