|
|
中医体质学在肺纤维化防治中应用的思考
|
Abstract:
肺纤维化是以多种原因导致肺部炎症、组织结构破坏为特征的一大类肺疾病的终末期改变。作为“呼吸系统中的难治病”，其好发于中老年人，病程长、预后不佳，在治疗上，西医治疗方式、药物少，且价格昂贵，效果也不理想甚至副作用明显。中医药治疗“肺痹”、“肺痿”已有数百年的历史，在肺纤维化的治疗上有一定的基础，而“中医体质学说”是国医大师王琦院士近年来提出的一项新的概念，结合中医体质学说治疗肺纤维化，响应了“健康中国”策略的号召，推动中医药的发展。
Pulmonary fibrosis is a major type of end-stage lung disease characterized by inflammation and tissue structure damage caused by various reasons. As a “difficult to treat disease in the respiratory system”, it is more common in middle-aged and elderly people, with a long disease course and poor prognosis. In terms of treatment, Western medicine has few treatment methods and drugs, and the price is expensive. The effect is not ideal and even the side effects are obvious. Traditional Chinese medicine has a history of hundreds of years in treating “pulmonary obstruction” and “pulmonary dysfunction”, and has a certain foundation in the treatment of pulmonary fibrosis. “Traditional Chinese Medicine constitution theory” is a new concept proposed by academician Wang Qi, a master of Chinese medicine, in recent years. Combining traditional Chinese medicine constitution theory to treat pulmonary fibrosis, it responds to the call of the “Healthy China” strategy and promotes the development of traditional Chinese medicine.
| [1] | Hirani, N., MacKinnon, A.C., Nicol, L., Ford, P., Schambye, H., Pedersen, A., et al. (2020) Target Inhibition of Galectin-3 by Inhaled TD139 in Patients with Idiopathic Pulmonary Fibrosis. European Respiratory Journal, 57, Article ID: 2002559. https://doi.org/10.1183/13993003.02559-2020 |
| [2] | Schafer, M.J., White, T.A., Iijima, K., et al. (2017) Cellular Senescence Mediates Fibrotic Pulmonary Disease. Nature Communications, 8, Article No. 14532. |
| [3] | Chanda, D., Otoupalova, E., Smith, S.R., Volckaert, T., De Langhe, S.P., Thannickal, V.J. (2019) Developmental Pathways in the Pathogenesis of Lung Fibrosis. Molecular Aspects of Medicine, 65, 56-69. https://doi.org/10.1016/j.mam.2018.08.004 |
| [4] | 邓岳潼, 吕晓东, 庞立健, 等. 基于“三因制宜”探析特发性肺纤维化防治原则研究进展[J]. 中华中医药学刊, 2019, 37(9): 2193-2195. |
| [5] | 石岩, 庞立健, 刘创, 等. 基于体质学说论特发性肺纤维化中医研究思路[J]. 中医杂志, 2017, 58(11): 926-928. |
| [6] | 张耀夫, 赵进喜. 赵进喜辨体论治肺间质纤维化[J]. 中医学报, 2020, 35(9): 1934-1938. |
| [7] | Nalysnyk, L., Cid-Ruzafa, J., Rotella, P. and Esser, D. (2012) Incidence and Prevalence of Idiopathic Pulmonary Fibrosis: Review of the Literature. European Respiratory Review, 21, 355-361. https://doi.org/10.1183/09059180.00002512 |
| [8] | Borie, R., Le Guen, P., Ghanem, M., Taillé, C., Dupin, C., Dieudé, P., et al. (2019) The Genetics of Interstitial Lung Diseases. European Respiratory Review, 28, Article ID: 190053. https://doi.org/10.1183/16000617.0053-2019 |
| [9] | Moore, C., Blumhagen, R.Z., Yang, I.V., Walts, A., Powers, J., Walker, T., et al. (2019) Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 200, 199-208. https://doi.org/10.1164/rccm.201810-1891oc |
| [10] | 王琦. 中医体质学[M]. 北京: 中国医药科技出版社, 1995: 24. |
| [11] | 段春磊, 王明航, 周林琼, 等. 肺纤维化中医药治疗述评[J]. 中国中医基础医学杂志, 2023, 29(4): 672-674. |
| [12] | 吴聪, 罗成, 王玉光, 等. 基于三期九候论治间质性肺疾病经验撷菁[J]. 中华中医药杂志, 2023, 38(4): 1580-1583. |
| [13] | Yao, C., Guan, X., Carraro, G., Parimon, T., Liu, X., Huang, G., et al. (2021) Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine, 203, 707-717. https://doi.org/10.1164/rccm.202004-1274oc |
| [14] | 杨正, 马明越, 王济, 等. “辨体-辨病-辨证”诊疗模式的创建与临床应用[J]. 现代中医临床, 2017, 24(3): 9-12. |
| [15] | Holland, A.E., Fiore, J.F., Bell, E.C., Goh, N., Westall, G., Symons, K., et al. (2014) Dyspnoea and Comorbidity Contribute to Anxiety and Depression in Interstitial Lung Disease. Respirology, 19, 1215-1221. https://doi.org/10.1111/resp.12360 |
| [16] | 陈玉柱. 润燥解毒、化痰活血、消积散结法治疗61例煤工尘肺病的疗效观察[J]. 光明中医, 2010, 25(9): 1594-1598. |
| [17] | 胡向洁. 肺间质纤维化患者中医体质分布规律研究[D]: [硕士学位论文]. 济南: 山东中医药大学, 2017. |
| [18] | 李小燕, 何焯根, 陈润东, 等. 300例冠心病患者中医体质类型与血脂水平的相关性分析[J]. 中西医结合心脑血管病杂志, 2015, 13(8): 964-966. |
| [19] | 陈维克, 张健新, 赵华, 等. 山东省干部保健人群原发性骨质疏松症与中医体质的相关性[J]. 中国医药科学, 2017, 7(19): 12-15. |
| [20] | Somogyi, V., Chaudhuri, N., Torrisi, S.E., Kahn, N., Müller, V. and Kreuter, M. (2019) The Therapy of Idiopathic Pulmonary Fibrosis: What Is Next? European Respiratory Review, 28, Article ID: 190021. https://doi.org/10.1183/16000617.0021-2019 |
| [21] | 秦静波, 李竹青, 孟翔鹤, 等. 大健康背景下中医体质学在恶性肿瘤防治中应用的思考[J]. 北京中医药大学学报, 2021, 44(9): 818-823. |
| [22] | 陈云凤, 刘洪, 李群英, 等. 补肺益肾、化瘀通络法治疗特发性肺间质纤维化的临床研究[J]. 中华中医药杂志, 2014, 29(9): 3030-3032. |
| [23] | 鞠铮嵘. 肺痿理论-晁恩祥名老中医治疗肺纤维化经验总结[D]: [硕士学位论文]. 北京: 北京中医药大学, 2014. |
| [24] | 江振国. 川芎嗪注射液治疗肺间质纤维化临床观察[J]. 中国中医药信息杂志, 2013, 20(9): 78-79. |
| [25] | 赵霞, 卢海燕, 孙轶秋. 120例哮喘患儿中医体质分型研究[J]. 南京中医药大学学报, 2014, 30(1): 27-29. |
| [26] | 白明华, 王济, 郑燕飞, 等. 基于108015例样本数据的中国人群中医体质类型分布特征分析[J]. 北京中医药大学学报, 2020, 43(6): 498-507. |
