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老年性耳聋中医基础研究进展
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Abstract:
老年性耳聋，又称年龄相关性听力下降(AHL)。随着社会老年化的发展，老年性耳聋的发病率逐年升高，已成为老年人群常见病和多发病。老年性耳聋不仅影响老年人的身心健康，还严重导致老年人的生活质量、认知水平、社交沟通能力下降等不良后果。由于属于听觉系统感音神经性退变，一直以来防治相当困难，系学界研究重点和难点。当今研究发现中医中药治疗AHL基础研究方面已取得可观成果，研究进展令人瞩目，本文就此进行回顾性总结，希望能为今后相关研究提供参考信息。
Presbycusis, also known as age-related hearing loss (AHL). With the development of aging society, the incidence of senile deafness is increasing year by year, and it has become a common and frequent disease in the elderly population. Age-related deafness not only affects the physical and mental health of the elderly, but also seriously leads to the quality of life, cognitive level, social communication ability of the elderly decline and other adverse consequences. Due to the sensorineural degeneration of the auditory system, it has been difficult to prevent and treat, and has been the focus of research in the academic community and difficult. Today, researchers have found that Chinese medicine has achieved considerable results in basic research on the treatment of AHL, and the progress of research has been remarkable. This article provides a retrospective summary of this topic, and we hope that it can provide reference information for future research.
| [1] | Huang, Q. and Tang, J. (2010) Age-Related Hearing Loss or Presbycusis. European Archives of Oto-Rhino-Laryngology, 267, 1179-1191. https://doi.org/10.1007/s00405-010-1270-7 |
| [2] | Tarnovsky, Y.C., Taiber, S., Nissan, Y., Boonman, A., Assaf, Y., Wilkinson, G.S., et al. (2023) Bats Experience Age-Related Hearing Loss (Presbycusis). Life Science Alliance, 6, e202201847. https://doi.org/10.26508/lsa.202201847 |
| [3] | Sun, Z., Cheng, Z., Gong, N., Xu, Z., Jin, C., Wu, H., et al. (2021) Neural Presbycusis at Ultra-High Frequency in Aged Common Marmosets and Rhesus Monkeys. Aging, 13, 12587-12606. https://doi.org/10.18632/aging.202936 |
| [4] | 丁大连, 李鹏, 亓卫东, 等. 不同种属实验动物耳蜗毛细胞年龄相关性缺失的不同模式[J]. 中国耳鼻咽喉颅底外科杂志, 2023, 29(4): 7-13. |
| [5] | Castaño-González, K., Köppl, C. and Pyott, S.J. (2024) The Crucial Role of Diverse Animal Models to Investigate Cochlear Aging and Hearing Loss. Hearing Research, 445, Article ID: 108989. https://doi.org/10.1016/j.heares.2024.108989 |
| [6] | Li, Z., Liu, R., Liu, Y., Zhao, M., Luan, J., Wang, Y., et al. (2022) H55 N Variation in Citrate Synthase Leads to Decrement in the Enzyme Activity and Transport Rate to Mitochondria in HEI-OC1 Cells. Biochemical and Biophysical Research Communications, 612, 134-140. https://doi.org/10.1016/j.bbrc.2022.04.104 |
| [7] | 周凌, 宣伟军, 丁大连. CBA/CaJ和C57BL/6J小鼠全耳蜗毛细胞随着年龄增长不同损害模式的比较[J]. 中国实验动物学报, 2019, 27(6): 790-798. |
| [8] | Xuan, W., Huang, L., Xuan, Y., Chen, S., Tang, J., Wei, Y., et al. (2024) Use of the Traditional Chinese Medicine “Compound Healthy Ear Agent” to Protect against Age-Related Hearing Loss in Mice: A Proteomics Study. Heliyon, 10, e26914. https://doi.org/10.1016/j.heliyon.2024.e26914 |
| [9] | Sheets, L., Holmgren, M. and Kindt, K.S. (2021) How Zebrafish Can Drive the Future of Genetic-Based Hearing and Balance Research. Journal of the Association for Research in Otolaryngology, 22, 215-235. https://doi.org/10.1007/s10162-021-00798-z |
| [10] | Xuan, Y., Ding, D., Xuan, W., et al. (2018) A Traditional Chinese Medicine Compound (Jian Er) for Presbycusis in a Mouse Model: Reduction of Apoptosis and Protection of Cochlear Sensorineural Cells and Hearing. International Journal of Herbal Medicine, 6, 127-135. |
| [11] | 宣伟军, 黄力毅, 宣毅, 等. 复方健耳剂对抗老年性耳蜗神经细胞凋亡超微结构观察及上调NeuN和BDNF定位表达作用[J]. 中国实验动物学报, 2020, 28(3): 338-344. |
| [12] | 向红, 彭斌. 基于耳蜗核钙结合蛋白含量的变化探讨复聪片延缓老年C57BL/6J小鼠听力下降的实验研究[J]. 中国中西医结合耳鼻咽喉科杂志, 2024, 32(3): 161-167. |
| [13] | 周令闻. 复聪片干预SIRT2延缓C57BL/6J小鼠老年性听力下降的机制研究[D]: [硕士学位论文]. 长沙: 湖南中医药大学, 2023. |
| [14] | Liu, Q., Li, N., Yang, Y., Yan, X., Dong, Y., Peng, Y., et al. (2021) Prediction of the Molecular Mechanisms Underlying Erlong Zuoci Treatment of Age-Related Hearing Loss via Network Pharmacology-Based Analyses Combined with Experimental Validation. Frontiers in Pharmacology, 12, Article ID: 719267. https://doi.org/10.3389/fphar.2021.719267 |
| [15] | 楚敏. 耳聋左慈丸调节miR-34a/SIRT1/p53通路介导的自噬与凋亡防治老年性聋的分子机制研究[D]: [博士学位论文]. 上海: 上海中医药大学, 2021 |
| [16] | 王艺蓉, 阎希芮, 欧阳朝明, 等. 耳聋左慈丸上调SIRT1减轻老年性聋小鼠耳蜗螺旋神经节细胞损伤的作用机制研究[J]. 上海中医药杂志, 2023, 57(8): 81-88. |
| [17] | 欧阳朝明. 耳聋左慈丸通过调节自噬防治老年性聋的机制研究[D]: [硕士学位论文]. 上海: 上海中医药大学, 2020. |
| [18] | 武莹, 王哲, 马贤德, 等. 耳聋左慈丸对老年性耳聋小鼠耳蜗组织cAMP含量及PKA表达的影响[J]. 中华中医药学刊, 2017, 35(6): 1548-1551. |
| [19] | 龚永昌, 李宁, 王艺蓉, 等. 耳聋左慈丸通过调节miR-34a对HEI-OC1听细胞自噬和凋亡的影响[J]. 中华中医药杂志, 2022, 37(2): 740-744. |
| [20] | Yang, Y., Yan, X., Wu, R., Li, N., Chu, M., Dong, Y., et al. (2022) Network Pharmacology and Experimental Evidence Reveal the Protective Mechanism of Yi-Qi Cong-Ming Decoction on Age-Related Hearing Loss. Pharmaceutical Biology, 60, 1478-1490. https://doi.org/10.1080/13880209.2022.2101671 |
| [21] | Li, N., Yan, X., Huang, W., Chu, M., Dong, Y., Song, H., et al. (2023) Curcumin Protects against the Age-Related Hearing Loss by Attenuating Apoptosis and Senescence via Activating Nrf2 Signaling in Cochlear Hair Cells. Biochemical Pharmacology, 212, Article ID: 115575. https://doi.org/10.1016/j.bcp.2023.115575 |
| [22] | 李晨, 温荣城, 李羿, 等. 天麻及其提取物对老年性耳聋小鼠疗效的对比研究[J]. 成都医学院学报, 2020, 15(6): 690-693+724. |
| [23] | Ahmad, B., Khan, S., Liu, Y., Xue, M., Nabi, G., Kumar, S., et al. (2020) Molecular Mechanisms of Anticancer Activities of Puerarin. Cancer Management and Research, 12, 79-90. https://doi.org/10.2147/cmar.s233567 |
| [24] | 张凤英, 周进, 隋轶. 葛根素对老年性耳聋以及学习记忆的干预作用[J]. 解剖科学进展, 2023, 29(6): 631-633+638. |
| [25] | 鲍捷. 穴位埋线干预老年性聋小鼠耳蜗螺旋神经节细胞Bcl-2及Bax表达的实验研究[D]: [硕士学位论文]. 沈阳: 辽宁中医药大学, 2019. |
| [26] | 王恒. 穴位埋线干预小鼠耳蜗螺旋神经元GABAA和NMDA受体时序性表达的实验研究[D]: [硕士学位论文]. 沈阳: 辽宁中医药大学, 2019. |
