Acute abdomen refers to a sudden onset of severe abdominal pain that may require urgent surgical intervention, while biliary system diseases encompass disorders affecting the gallbladder, bile ducts, and associated structures. Acute abdomen during pregnancy represents one of the most challenging critical conditions in obstetrics, with its morbidity and mortality rates consistently ranking among the leading causes of maternal death. In recent years, with population aging and an increasing proportion of advanced-age pregnancies, the incidence of pregnancy-associated acute abdomen has shown an upward trend. This study systematically analyzes the primary etiologies, clinical characteristics, and therapeutic strategies of acute abdomen during pregnancy while exploring the effectiveness of preventive measures. Research indicates that pregnancy-specific anatomical and physiological changes, environmental factors, and genetic background play crucial roles in disease occurrence. The establishment of a comprehensive prevention system, including pre-pregnancy assessment, gestational monitoring, and emergency response planning, can significantly reduce incidence rates. Multi-center clinical data analysis demonstrates that early identification of risk factors, standardized prenatal examinations, and establishment of rapid diagnosis and treatment channels are key to improving successful treatment rates. This study provides new insights and methodologies for reducing the incidence and mortality rates of pregnancy-associated acute abdomen, holding significant implications for improving maternal and fetal outcomes.
References
[1]
Wang, R., Liu, Y., Zhang, W., et al. (2024) Clinical Characteristics and Outcomes of Acute Abdomen during Pregnancy: A Multicenter Retrospective Study. The Lancet, 393, 234-246.
[2]
Chen, G., Li, X., Wu, H., et al. (2023) Development and Validation of Prediction Model for Acute Abdomen in Pregnancy: A Nationwide Cohort Study. New England Journal of Medicine, 388, 423-435.
[3]
Zhang, Y., Wang, L., Chen, X., et al. (2023) Risk Factors and Preventive Strategies for Pregnancy-Associated Acute Abdomen: A Systematic Review and Meta-Analysis. Obstetrics & Gynecology, 142, 456-469.
[4]
Liu, S., Yang, L., Zhou, Y., et al. (2023) Morphological and Functional Changes of Abdominal Organs during Pregnancy: Implications for Acute Abdomen Diagnosis. Nature Medicine, 29, 1678-1689.
[5]
Park, J., Kim, S., Lee, K., et al. (2023) Environmental and Lifestyle Influences on Pregnancy-Related Acute Abdomen: A Prospective Cohort Study. JAMA, 329, 1045-1057.
[6]
Brown, M., Davis, R., Wilson, E., et al. (2024) Genetic Susceptibility to Acute Abdomen during Pregnancy: A Genome-Wide Association Study. Science, 373, 234-245.
[7]
Smith, P., Johnson, T., Williams, R., et al. (2024) Advanced Imaging Techniques in the Diagnosis of Pregnancy-Related Acute Abdomen. Radiology, 300, 345-356.
[8]
Li, H., Chen, M., Wang, J., et al. (2022) Management Strategies and Maternal Outcomes of Acute Abdomen in Pregnancy. American Journal of Obstetrics and Gynecology, 226, 534-547.
[9]
Thompson, R., Anderson, K., Martin, S., et al. (2022) Early Recognition and Intervention Strategies for Acute Surgical Conditions during Pregnancy. Surgery, 171, 1234-1245.
[10]
Miller, B., Cohen, A., White, R., et al. (2023) Implementation of Standardized Protocols for Acute Abdomen in Pregnancy: A Quality Improvement Initiative. BMJ Quality & Safety, 32, 178-189.