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大柴胡汤治疗胃食管反流病的研究进展
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Abstract:
胃食管反流病(GERD)是一种由酸性胃内容物反流进入食管导致食管损伤的消化系统疾病，胃酸和酸性胆盐会加剧食管上皮细胞的氧化应激反应并导致炎症反应的加剧，进而破坏食管黏膜的完整性。中医学认为GERD是多种因素导致胃气上逆而引起。现代中医名家从丰富的物质条件和社会环境变化的角度出发，认为肝胃不和、脾虚湿热和肺胃失和为GERD的病因病机。大柴胡汤具有疏肝解郁、内泻阳明之热，调畅脾胃气机的功效。实验研究发现大柴胡汤具有抗炎和抗氧化应激的作用。本文将GERD的病因病机、大柴胡汤对其治疗机制及临床运用其综述如下，为临床运用大柴胡汤治疗GERD提供治疗依据。
Gastroesophageal reflux disease (GERD) is a digestive system disease caused by the reflux of acidic gastric contents into the esophagus, resulting in esophageal damage. Gastric acid and acidic bile salts can exacerbate the oxidative stress response of esophageal epithelial cells and lead to an exacerbation of inflammatory reactions, thereby damaging the integrity of the esophageal mucosa. Traditional Chinese Medicine believes that GERD is caused by multiple factors leading to the reversal of gastric qi. Modern Chinese medicine experts, from the perspective of abundant material conditions and changes in social environment, believe that liver stomach disharmony, spleen deficiency, damp heat, and lung stomach disharmony are the etiology and pathogenesis of GERD. Major Bupleurum Decoction has the effects of soothing the liver, relieving depression, promoting internal diarrhea of Yangming heat, and regulating spleen and stomach qi. Experimental research has found that Major Bupleurum Decoction has anti-inflammatory and antioxidant stress relieving effects. This article provides a review of the etiology and pathogenesis of GERD, as well as the therapeutic mechanism and clinical application of Major Bupleurum Decoction, in order to provide a basis for the clinical use of Major Bupleurum Decoction in the treatment of GERD.
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