|
|
类风湿关节炎患者长期服用硫酸羟氯喹出现视网膜黄斑的案例分享
|
Abstract:
硫酸羟氯喹(hydroxychloroquine, HCQ)广泛应用于自身免疫性结缔组织疾病，是治疗类风湿性关节炎常用药物，硫酸羟氯喹具有抗疟、免疫调节、抗病毒等作用，它通过多种方式发挥免疫抑制作用，比如通过抑制内溶酶体、控制炎症因子的释放等方式。硫酸羟氯喹广泛地应用于临床中，不仅能够控制病情，而且还能够极大地降低糖皮质激素的使用量，从而降低患者的复发频率，其临床效果较好。
Hydroxychloroquine sulfate (HCQ) is widely used in autoimmune connective tissue diseases and is a commonly prescribed drug for rheumatoid arthritis. Hydroxychloroquine sulfate has antimalarial, immunomodulatory, and antiviral effects. It exerts immunosuppressive effects through various mechanisms, such as inhibiting lysosomes and controlling the release of inflammatory factors. Hydroxychloroquine sulfate is extensively applied in clinical practice, not only for controlling the disease but also for significantly reducing the dosage of glucocorticoids, thereby lowering the recurrence rate of patients, its clinical efficacy is relatively good.
| [1] | 赵慧霞, 王彩虹, 罗静, 等. 羟氯喹在系统性红斑狼疮治疗中的研究进展[J]. 中国药物与临床, 2012, 12(7): 920-921. |
| [2] | Salu, P., Uvijls, A., van den Brande, P. and Leroy, B.P. (2010) Normalization of Generalized Retinal Function and Progression of Maculopathy after Cessation of Therapy in a Case of Severe Hydroxychloroquine Retinopathy with 19 Years Follow-Up. Documenta Ophthalmologica, 120, 251-264. https://doi.org/10.1007/s10633-010-9220-7 |
| [3] | Mititelu, M., Wong, B.J., Brenner, M., Bryar, P.J., Jampol, L.M. and Fawzi, A.A. (2013) Progression of Hydroxychloroquine Toxic Effects after Drug Therapy Cessation: New Evidence from Multimodal Imaging. JAMA Ophthalmology, 131, 1187-1197. https://doi.org/10.1001/jamaophthalmol.2013.4244 |
| [4] | Mittal, N., Sharma, A., Jose, V., Mittal, R., Wanchu, A. and Bambery, P. (2010) Causes of DMARD Withdrawal Following ADR within 6 Months of Initiation among Indian Rheumatoid Arthritis Patients. Rheumatology International, 32, 743-748. https://doi.org/10.1007/s00296-010-1646-4 |
| [5] | Schraermeyer, U., Peters, S., Thumann, G., Kociok, N. and Heimann, K. (1999) Melanin Granules of Retinal Pigment Epithelium Are Connected with the Lysosomal Degradation Pathway. Experimental Eye Research, 68, 237-245. https://doi.org/10.1006/exer.1998.0596 |
| [6] | 韩晓晓, 邓国民. 氯喹及羟氯喹在风湿性自身免疫病中的研究进展[J]. 医学研究杂志, 2022, 51(4): 10-13, 17. |
| [7] | Sundelin, S.P. and Terman, A. (2002) Different Effects of Chloroquine and Hydroxychloroquine on Lysosomal Function in Cultured Retinal Pigment Epithelial Cells. APMIS, 110, 481-489. https://doi.org/10.1034/j.1600-0463.2002.100606.x |
| [8] | Marmor, M.F., Kellner, U., Lai, T.Y.Y., Lyons, J.S. and Mieler, W.F. (2011) Revised Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy. Ophthalmology, 118, 415-422. https://doi.org/10.1016/j.ophtha.2010.11.017 |
| [9] | Lee, W.J., Ko, M. and Lee, B.R. (2011) Hydroxychloroquine Retinopathy Combined with Retinal Pigment Epithelium Detachment. Cutaneous and Ocular Toxicology, 31, 144-147. https://doi.org/10.3109/15569527.2011.627076 |
