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基于TGF-β信号通路探讨中医药治疗骨折的研究进展
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Abstract:
骨折发病人数呈增长趋势，具有多高危并发症、高致残率、恢复期长等难点。本文通过综述近几年国内外关于TGF-β信号通路在骨折愈合以及中医药通过调控TGF-β信号通路治疗骨折方面研究文献发现，TGF-β家族在骨折愈合中发挥关键作用，其可激活TGF-β/Smad信号通路，促进成骨细胞活性和抑制破骨细胞来加速愈合，具有多成分、多途径、多靶点的优势，中药复方、单味中药及外治法均显示出促进TGF-β分泌和表达，激活成骨细胞，抑制破骨细胞的潜力。未来研究需进一步探索中医药对TGF-β信号通路的具体调控机制，开展更大规模多中心、大样本临床试验，为今后骨折的临床治疗和基础研究提供更多新思路以及详实循证依据，以优化中医药新成果转化、临床指南和方案制定。
The number of fracture cases is on the rise, presenting challenges such as multiple high-risk complications, a high disability rate, and a long recovery period. Through reviewing literature from both domestic and international sources over the past few years concerning the TGF-β signaling pathway in bone fracture healing, and the research on traditional Chinese medicine (TCM) regulating the TGF-β signaling pathway for fracture treatment, it has been found that the TGF-β family plays a crucial role in bone fracture healing. It can activate the TGF-β/Smad signaling pathway, promote osteoblast activity, and inhibit osteoclasts to accelerate healing. This pathway offers advantages with multiple components, pathways, and targets. Traditional Chinese herbal formulas, single herbs, and external treatments all demonstrate the potential to promote TGF-β secretion and expression, activate osteoblasts, and inhibit osteoclasts. Future research needs to further explore the specific regulatory mechanisms of TCM on the TGF-β signaling pathway, conduct larger multi-center and large sample clinical trials, provide more new ideas and detailed evidence-based references for the clinical treatment and basic research of fractures in the future, and optimize the transformation of new TCM results, clinical guidelines, and protocol formulations.
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