Pregnancy in cirrhotic-woman is a rare event [1] [2]. It causes particular risks related to liver disease and its treatments, with maternal and fetal consequences. The largest reported series to date is by Welton’s with 13 cases [3]. In Africa, few cases were reported. The purpose of this work was to report the hepatic and obstetric complications in pregnant women in Burkina Faso, a low-income country. It was a descriptive cross-sectional study with retrospective data collection covering the period from January 1, 2013 to December 31, 2023. All the women diagnosed with cirrhosis through clinical basis, biological and imaging arguments associated with a pregnancy confirmed by ultrasound were included. A total of ten women were included in the study. Among them, two were known cirrhotics and were being followed. In the other eight cases, cirrhosis was discovered during pregnancy. Eight women were HBsAg positive and two of them had only the contact marker of hepatitis B virus (anti- HBc antibody). The evolution was, ascitic decompensation in nine cases, digestive hemorrhage due to rupture of esophageal varices in two cases, nine cases of anemia, two cases of ascitic fluid infection and one case of conjunctival jaundice. Two cases of probable hepatocellular carcinoma were noted with one case of extensive portal thrombosis. The evolution was without maternal complications in one case. Regarding fetal and neonatal complications, there were three cases of hypotrophy, one case of prematurity, one case of acute neonatal distress, two cases of fetal death in utero and one case of fetal tachycardia. Four pregnancies had a favorable evolution without any complications. The association of cirrhosis and pregnancy is an uncommon event, and maternal and fetal complications can occur, making this pregnancy a high-risk pregnancy.
References
[1]
Shaheen, A.A.M. and Myers, R.P. (2010) The Outcomes of Pregnancy in Patients with Cirrhosis: A Population-Based Study. Liver International, 30, 275-283. https://doi.org/10.1111/j.1478-3231.2009.02153.x
[2]
(2016) TS Health Maghreb—Health Library Maghreb. https://www.santemaghreb.com
[3]
Whelton, M.J. and Sherlock, S. (1968) Pregnancy in Patients with Hepatic Cirrhosis. The Lancet, 292, 995-999. https://doi.org/10.1016/s0140-6736(68)91294-4
[4]
Sermé, A.K., Somda, K.S., Coulibaly, A., Sawadogo, A., Koura, M., Kouamou, Y.S., et al. (2018) Pregnancy and Cirrhosis in the University Hospital Yalgado Ouedraogo in Burkina Faso: A Report of Five Cases. EC Gastroenterology and Digestive System, 5, 1-6.
[5]
Diarra, M., Konaté, A., Kallé, A., Sow, H., Doumbia Samaké, K. and Maiga, M.-. (2007) Grossesse sur cirrhose: À propos d’un cas. Journal Africain d’Hépato-Gastroentérologie, 1, 143-145. https://doi.org/10.1007/s12157-008-0035-z
[6]
N’Guessan, E., Kouakou, F., Binan, Y., Guie, P., Dia, J.M., Doukoure, B., et al. (2007) Hepatic Cirrhosis and Pregnancy: A Case Report. Medecined’Afrique noire, 54, 253-256.
[7]
Dridi, M., Mahdaoui, S., Bouzyiane, N., Laghzaoui, M., Bennani, O. and Bouhya, S. (2009) Cirrhosis and Pregnancy about a Case. Journal Marocain des Sciences Médicales, 16, 55-62.
[8]
Ndububa, D.A., Makinde, O.N., Ojo, O.S., Adetiloye, V.A. and Debayo, R.A.A. (2002) Pregnancy in Nigerian Women with Liver Cirrhosis: A Report of Three Cases. Journal of Obstetrics and Gynaecology, 22, 92-94. https://doi.org/10.1080/01443610211108
[9]
Voitot, H. (2006) Biologie et cirrhose. Revue Francophone des Laboratoires, 2006, 65-71. https://doi.org/10.1016/s1773-035x(06)80500-9
[10]
Ouavene, J.O., Koffi, B., Mobima, T., Bekondji, C., Massengue, A. and Guenebem, A.K. (2014) Liver Cirrhosis at the Bangui Friendship Hospital: Epidemiological, Clinical, Ultrasound Aspects and Diagnostic Problems. Journal Africain d’ImagerieMédicale, 5, 1-12.
[11]
Somé, E.N., Guingané, N.A., Lompo, T.I. and Sombié, R. (2021) Liver Cirrhosis: Epidemiological and Diagnostic Aspects at the Yalgado Ouédraogo University Hospital. Rev. Afr Sci Soc Public Health, 3, 53-64.
[12]
Meda, N., Tuaillon, E., Kania, D., Tiendrebeogo, A., Pisoni, A., Zida, S., et al. (2018) Hepatitis B and C Virus Seroprevalence, Burkina Faso: A Cross-Sectional Study. Bulletin of the World Health Organization, 96, 750-759. https://doi.org/10.2471/blt.18.208603
[13]
Balian, A., Balian, C. and Sorenssen, B. (2007) Passing the ECN in Hepato-Gastroenterology. 3rd Edition, ELLIPSES, 119-126.
[14]
Delluc, C., Costedoat-Chalumeau, N., Leroux, G., Imbert, G., Le Thi Huong, D., Vauthier-Brouzes, D., et al. (2009) Pathologies hépatiques et grossesse. La Revue de Médecine Interne, 30, 508-515. https://doi.org/10.1016/j.revmed.2008.09.012
[15]
Tiribelli, C. and Rigato, I. (2006) Liver Cirrhosis and Pregnancy. Annals of Hepatology, 5, 201. https://doi.org/10.1016/s1665-2681(19)32011-3
[16]
Moukit, M., Adioui, T., Kouach, J., El Mangoub, F., El Hassani, M.E.M., Aourarh, A., et al. (2018) Successful pregnancy in a cirrhotic patient. Batna Journal of Medical Sciences (BJMS), 5, 91-92. https://doi.org/10.48087/bjmscr.2018.5122
[17]
Itoudi Bignoumba, P.E., Maganga Moussavou, I.F., Eyi Nguema, A.G., Minkobame, U. and Moussavou Kombila, J.B. (2022) Pregnancy and Cirrhosis: Epidemiological and Prognostic Aspects of 7 Cases Followed at the University Hospital of Libreville. Bulletin Médicald’Owendo, 20, 75-79.
[18]
García-Romero, C.S., Guzman, C., Cervantes, A. and Cerbón, M. (2019) Liver Disease in Pregnancy: Medical Aspects and Their Implications for Mother and Child. Annals of Hepatology, 18, 553-562. https://doi.org/10.1016/j.aohep.2019.04.009
Scaglione, S. (1923) Cirrhosis of laennec on gravidanza. Riv Italian Ginecol, 1, 489.
[21]
Tan, J., Surti, B. and Saab, S. (2008) Pregnancy and Cirrhosis. Liver Transplantation, 14, 1081-1091. https://doi.org/10.1002/lt.21572
[22]
Sawadogo, A., Dib, N. and Calès, P. (2007) Pathophysiology of Cirrhosis and Its Complications. Resuscitation, 16, 557-562.
[23]
Peck-Radosavljevic, M. (2016) Thrombocytopenia in Chronic Liver Disease. Liver International, 37, 778-793. https://doi.org/10.1111/liv.13317
[24]
Ditisheim, S., Goossens, N., Spahr, L. and Hadengue, A. (2012) Coagulation et cirrhose: Un nouveau regard. Revue Médicale Suisse, 8, 1652-1656. https://doi.org/10.53738/revmed.2012.8.352.1652
[25]
Pariente, A. (2017) Bacterial Infection Increases Mortality in Patients with Compensated Viral Cirrhosis. Hepato-Gastro & Digestive Oncology, 24, 539-543.
[26]
Christou, L., Pappas, G. and Falagas, M.E. (2007) Bacterial Infection-Related Morbidity and Mortality in Cirrhosis. The American Journal of Gastroenterology, 102, 1510-1517. https://doi.org/10.1111/j.1572-0241.2007.01286.x
[27]
Chauvet, P., Terral, D., Colombier, M., Mulliez, A., Suarez, C., Brunhes, A., et al. (2016) Injection de produit de contraste iodé en cours de grossesse et fonction thyroïdienne néonatale. Gynécologie Obstétrique & Fertilité, 44, 685-689. https://doi.org/10.1016/j.gyobfe.2016.09.011
[28]
Karoui, S., Hamzaoui, S., Sanfi, F. and Matri, S. (2002) Mortality in Cirrhosis: Prevalence, Causes and Predictive Factors. TunisieMédicale, 80, 21-25.
[29]
Lalonde, G. (1974) Cirrhosis and Pregnancy. Doctor’s Thesis, Caen University, 167
[30]
Esposti, S.D. (2014) Pregnancy in Patients with Advanced Chronic Liver Disease Clinical Liver Disease Clinical Liver Disease, 4, 62-68. https://doi.org/10.1002/cld.415
[31]
Nousbaum, J. (2015) Infection spontanée du liquide d’ascite au cours de la cirrhose. La Presse Médicale, 44, 1235-1242. https://doi.org/10.1016/j.lpm.2015.07.017
[32]
Englesbe, M.J., Kubus, J., Muhammad, W., Sonnenday, C.J., Welling, T., Punch, J.D., et al. (2009) Portal Vein Thrombosis and Survival in Patients with Cirrhosis. Liver Transplantation, 16, 83-90. https://doi.org/10.1002/lt.21941
[33]
Ruiz, I. and Féray, C. (2015) Prise en charge du carcinome hépatocellulaire. Cancer/Radiothérapie, 19, 410-415. https://doi.org/10.1016/j.canrad.2015.05.008
[34]
Parikh-Patel, A., Gold, E., Utts, J. and Gershwin, M.E. (2002) The Association between Gravidity and Primary Biliary Cirrhosis. Annals of Epidemiology, 12, 264-272. https://doi.org/10.1016/s1047-2797(01)00277-0