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槲皮素降尿酸作用机制研究进展
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Abstract:
高尿酸血症是人体内尿酸生成与排泄稳态失衡的一种常见代谢性疾病，与痛风、肾结石、高血压等疾病密切相关。随着人们生活质量的提高和高嘌呤饮食的频繁摄入，高尿酸血症的发病率越来越高，发病年龄越来越低。目前对于高尿酸血症的临床治疗，西药大多具有严重的副作用和局限性，因此需要寻求有效、安全的替代治疗方法。大量研究发现中药在治疗高尿酸血症方面具有良好的疗效性和安全性。槲皮素因其天然的黄嘌呤氧化酶抑制特性而引起广泛研究，有关其降尿酸机制的研究已多次出现在相关文献和基础研究中，因此本文对其研究进行了系统综述。
Hyperuricemia acid is a common metabolic disorder with imbalance of uric acid production and excretion. It is closely related to gout, kidney stones and hypertension. With the improvement of People’s quality of life and the frequent intake of high purine diet, the incidence of Hyperuricemia is higher and higher, and the age of onset is lower and lower. At present, Western medicine has serious side effects and limitations in the clinical treatment of Hyperuricemia, so it is necessary to seek effective and safe alternative therapies. A large number of studies have found that traditional Chinese medicine has good efficacy and safety in the treatment of Hyperuricemia. Quercetin is widely studied because of its natural Xanthine oxidase inhibitory properties. The mechanism of quercetin in reducing uric acid has appeared in the relevant literature and basic research many times, therefore, this paper makes a systematic review of its research.
| [1] | Dalbeth, N., Merriman, T.R. and Stamp, L.K. (2016) Gout. The Lancet, 388, 2039-2052. https://doi.org/10.1016/s0140-6736(16)00346-9 |
| [2] | Petreski, T., Ekart, R., Hojs, R. and Bevc, S. (2020) Hyperuricemia, the Heart, and the Kidneys—To Treat or Not to Treat? Renal Failure, 42, 978-986. https://doi.org/10.1080/0886022x.2020.1822185 |
| [3] | Koo, B.S., Jeong, H., Son, C., Kim, S., Kim, H.J., Kim, G., et al. (2021) Distribution of Serum Uric Acid Levels and Prevalence of Hyper-and Hypouricemia in a Korean General Population of 172,970. The Korean Journal of Internal Medicine, 36, S264-S272. https://doi.org/10.3904/kjim.2020.116 |
| [4] | Butler, F., Alghubayshi, A. and Roman, Y. (2021) The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database Analysis. Journal of Personalized Medicine, 11, Article No. 231. https://doi.org/10.3390/jpm11030231 |
| [5] | Zhu, C., Xu, Y., Liu, Z., Wan, X., Li, D. and Tai, L. (2018) The Anti-Hyperuricemic Effect of Epigallocatechin-3-Gallate (EGCG) on Hyperuricemic Mice. Biomedicine & Pharmacotherapy, 97, 168-173. https://doi.org/10.1016/j.biopha.2017.10.013 |
| [6] | Takahama, U., Koga, Y., Hirota, S. and Yamauchi, R. (2011) Inhibition of Xanthine Oxidase Activity by an Oxathiolanone Derivative of Quercetin. Food Chemistry, 126, 1808-1811. https://doi.org/10.1016/j.foodchem.2010.12.009 |
| [7] | Dabeek, W.M. and Marra, M.V. (2019) Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients, 11, Article No. 2288. https://doi.org/10.3390/nu11102288 |
| [8] | Shi, Y. and Williamson, G. (2016) Quercetin Lowers Plasma Uric Acid in Pre-Hyperuricaemic Males: A Randomised, Double-Blinded, Placebo-Controlled, Cross-Over Trial. British Journal of Nutrition, 115, 800-806. https://doi.org/10.1017/s0007114515005310 |
| [9] | Zhang, C., Wang, R., Zhang, G. and Gong, D. (2018) Mechanistic Insights into the Inhibition of Quercetin on Xanthine Oxidase. International Journal of Biological Macromolecules, 112, 405-412. https://doi.org/10.1016/j.ijbiomac.2018.01.190 |
| [10] | Yu, Y., Xiong, Y., Tong, S., Li, Y., Cai, R., Zhang, X., et al. (2025) Inhibitory Activity of Quercetin, Rutin, and Hyperoside against Xanthine Oxidase: Kinetics, Fluorescence, and Molecular Docking. Current Pharmaceutical Biotechnology, 26, 513-524. https://doi.org/10.2174/0113892010297269240427055003 |
| [11] | 姚芳芳, 张锐, 傅瑞娟, 等. 槲皮素对高尿酸血症大鼠黄嘌呤氧化酶和腺苷脱氨酶活性的影响[J]. 郑州大学学报(医学版), 2011, 46(2): 248-251. |
| [12] | Graf, B.A., Ameho, C., Dolnikowski, G.G., Milbury, P.E., Chen, C. and Blumberg, J.B. (2006) Rat Gastrointestinal Tissues Metabolize Quercetin. The Journal of Nutrition, 136, 39-44. https://doi.org/10.1093/jn/136.1.39 |
| [13] | Bieger, J., Cermak, R., Blank, R., de Boer, V.C.J., Hollman, P.C.H., Kamphues, J., et al. (2008) Tissue Distribution of Quercetin in Pigs after Long-Term Dietary Supplementation. The Journal of Nutrition, 138, 1417-1420. https://doi.org/10.1093/jn/138.8.1417 |
| [14] | Hu, Q., Wang, C., Li, J., Zhang, D. and Kong, L. (2009) Allopurinol, Rutin, and Quercetin Attenuate Hyperuricemia and Renal Dysfunction in Rats Induced by Fructose Intake: Renal Organic Ion Transporter Involvement. American Journal of Physiology-Renal Physiology, 297, F1080-F1091. https://doi.org/10.1152/ajprenal.90767.2008 |
| [15] | Hu, Q., Zhang, X., Pan, Y., Li, Y. and Kong, L. (2012) Allopurinol, Quercetin and Rutin Ameliorate Renal NLRP3 Inflammasome Activation and Lipid Accumulation in Fructose-Fed Rats. Biochemical Pharmacology, 84, 113-125. https://doi.org/10.1016/j.bcp.2012.03.005 |
| [16] | Yao, F., Zhang, R., Fu, R., et al. (2011) Preventive and Therapeutic Effects of Quercetin on Hyperuricemia and Renal Injury in Rats. Journal of Hygiene Research, 40, 175-177. |
| [17] | 赵悦. 槲皮素对尿酸损伤肾小管上皮细胞保护的研究[D]: [硕士学位论文]. 哈尔滨: 哈尔滨医科大学, 2014. |
| [18] | 彭艳, 邱慧磊, 史为伍, 等. 槲皮素对非沉积高尿酸血症肾损伤的保护作用[J]. 中医药学报, 2013, 41(3): 63-66. |
| [19] | Matsuo, H., Takada, T., Ichida, K., Nakamura, T., Nakayama, A., Ikebuchi, Y., et al. (2009) Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population. Science Translational Medicine, 1, 5ra11. https://doi.org/10.1126/scitranslmed.3000237 |
| [20] | Ichida, K., Matsuo, H., Takada, T., Nakayama, A., Murakami, K., Shimizu, T., et al. (2012) Decreased Extra-Renal Urate Excretion Is a Common Cause of Hyperuricemia. Nature Communications, 3, Article No. 764. https://doi.org/10.1038/ncomms1756 |
| [21] | Yano, H., Tamura, Y., Kobayashi, K., Tanemoto, M. and Uchida, S. (2013) Uric Acid Transporter ABCG2 Is Increased in the Intestine of the 5/6 Nephrectomy Rat Model of Chronic Kidney Disease. Clinical and Experimental Nephrology, 18, 50-55. https://doi.org/10.1007/s10157-013-0806-8 |
| [22] | Zhang, M., Lin, L. and Liu, H. (2018) Acute Effect of Soy and Soy Products on Serum Uric Acid Concentration among Healthy Chinese Men. Asia Pacific Journal of Clinical Nutrition, 27, 1239-1242. |
| [23] | DeBosch, B.J., Kluth, O., Fujiwara, H., Schürmann, A. and Moley, K. (2014) Early-Onset Metabolic Syndrome in Mice Lacking the Intestinal Uric Acid Transporter Slc2a9. Nature Communications, 5, Article No. 4642. https://doi.org/10.1038/ncomms5642 |
| [24] | 陈海青, 周璇, 王秀秀. 槲皮素治疗高尿酸血症的机制研究[J]. 光明中医, 2019, 34(9): 1340-1344. |
| [25] | Sorensen, L.B. (1965) Role of the Intestinal Tract in the Elimination of Uric Acid. Arthritis & Rheumatism, 8, 694-706. https://doi.org/10.1002/art.1780080429 |
| [26] | Liu, Y., Jarman, J.B., Low, Y.S., Augustijn, H.E., Huang, S., Chen, H., et al. (2023) A Widely Distributed Gene Cluster Compensates for Uricase Loss in Hominids. Cell, 186, 3400-3413.e20. https://doi.org/10.1016/j.cell.2023.06.010 |
| [27] | Roxon, J.J., Ryan, A.J. and Wright, S.E. (1966) Reduction of Tartrazine by a Proteus Species Isolated from Rats. Food and Cosmetics Toxicology, 4, 419-426. https://doi.org/10.1016/s0015-6264(66)80583-7 |
| [28] | Yamada, N., Iwamoto, C., Kano, H., Yamaoka, N., Fukuuchi, T., Kaneko, K., et al. (2016) Evaluation of Purine Utilization by Lactobacillus gasseri Strains with Potential to Decrease the Absorption of Food-Derived Purines in the Human Intestine. Nucleosides, Nucleotides & Nucleic Acids, 35, 670-676. https://doi.org/10.1080/15257770.2015.1125000 |
| [29] | Nei, S., Matsusaki, T., Kawakubo, H., Ogawa, K., Nishiyama, K., Tsend-Ayush, C., et al. (2024) Lactiplantibacillus plantarum 06CC2 Enhanced the Expression of Intestinal Uric Acid Excretion Transporter in Mice. Nutrients, 16, Article No. 3042. https://doi.org/10.3390/nu16173042 |
| [30] | Just, S., Mondot, S., Ecker, J., Wegner, K., Rath, E., Gau, L., et al. (2018) The Gut Microbiota Drives the Impact of Bile Acids and Fat Source in Diet on Mouse Metabolism. Microbiome, 6, Article No. 134. https://doi.org/10.1186/s40168-018-0510-8 |
| [31] | 任科雨, 勇春明, 金延春, 等. 青岛地区高尿酸血症患者的肠道菌群分析[J]. 中国医师杂志, 2014, 16(12): 1649-1651, 1656. |
| [32] | 曹统. 益生菌对高尿酸血症小鼠血清尿酸水平的影响及机制[D]: [博士学位论文]. 青岛: 青岛大学, 2017. |
| [33] | Li, D., Zhang, M., Teng Zhu La, A.L., Lyu, Z., Li, X., Feng, Y., et al. (2023) Quercetin-Enriched Lactobacillus aviarius Alleviates Hyperuricemia by Hydrolase-Mediated Degradation of Purine Nucleosides. Pharmacological Research, 196, Article ID: 106928. https://doi.org/10.1016/j.phrs.2023.106928 |
| [34] | Silva, J.C.P., Mota, M., Martins, F.O., Nogueira, C., Gonçalves, T., Carneiro, T., et al. (2018) Intestinal Microbial and Metabolic Profiling of Mice Fed with High-Glucose and High-Fructose Diets. Journal of Proteome Research, 17, 2880-2891. https://doi.org/10.1021/acs.jproteome.8b00354 |
| [35] | 张晨宇. 槲皮素对高尿酸血症小鼠炎症因子及肠道菌群的影响[D]: [硕士学位论文]. 开封: 河南大学, 2021. |
