|
|
心力康丸联合西医治疗射血分数下降型慢性心力衰竭的临床观察
|
Abstract:
目的：探究心力康丸治疗射血分数下降型慢性心力衰竭的临床疗效及安全性。方法：选取2023年9月~2024年12月在湖北省十堰市中医医院门诊就诊及住院部住院的符合先前制订的纳入标准和排除标准198名心力衰竭的患者。按随机双盲法进行分组，每组各99例。对照组给予安慰剂进行治疗，试验组给予心力康丸进行治疗，干预时间为3个月。测定两组治疗前后6分钟步行距离(6MWD)、中医证候评分、NT-proBNP。结果：治疗前后6分钟步行距离(6MWD)、中医证候评分、NT-proBNP比较，试验组均优于对照组(P < 0.05)。结论：心力康丸治疗射血分数下降型慢性心力衰竭的疗效显著，值得临床推广并使用。
Objective: To explore the clinical efficacy and safety of Xinlikang pills in the treatment of chronic heart failure with reduced ejection fraction. Methods: A total of 198 patients with heart failure, who met the predefined inclusion and exclusion criteria and were admitted to the outpatient and inpatient departments of Hubei Shiyan Hospital of Traditional Chinese Medicine from September 2023 to December 2024, were selected. They were randomly and doubly blinded divided into two groups, with 99 patients in each group. The control group received a placebo, while the experimental group received Xinlikang pills. The intervention period lasted for 3 months. The 6-minute walk distance (6MWD), Traditional Chinese Medicine (TCM) syndrome score, and NT-proBNP were measured before and after treatment in both groups. Results: Comparison of the 6MWD, TCM syndrome score, and NT-proBNP before and after treatment showed that the experimental group performed better than the control group (P < 0.05). Conclusion: Xinlikang pills demonstrate significant efficacy in the treatment of chronic heart failure with reduced ejection fraction and are worthy of clinical promotion and use.
| [1] | 许晓华, 季春影, 刘凤岐, 等. 心电图对慢性心力衰竭治疗的疗效及预后的评估[J]. 中国循证心血管医学杂志, 2018, 10(10): 1266-1268. |
| [2] | 周浩斌. 不同左室射血分数心力衰竭患者临床特征和预后的回顾性分析[D]: [硕士学位论文]. 广州: 南方医科大学, 2017. |
| [3] | 林乐语. 北京地区急诊心力衰竭患者三年预后、治疗现状及预后危险因素分析[D]: [博士学位论文]. 北京: 北京协和医学院, 2016. |
| [4] | 李智玲, 曹宏, 张锐. 心力衰竭药物治疗现状与进展[J]. 临床军医杂志, 2018, 46(10): 1212-1216. |
| [5] | 唐倩. 心衰患者如何自我管理[J]. 健康博览, 2022(7): 36-37. |
| [6] | 中华医学会心血管病学分会心力衰竭学组中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018 [J]. 中华心血管病杂志, 2018, 46(10): 760-789. |
| [7] | 中华中医药学会慢性心力衰竭中医诊疗指南项目组. 慢性心力衰竭中医诊疗指南(2022年) [J]. 中医杂志, 2023, 64(7): 743-756. |
| [8] | 潘锋. 心衰中心建设显著提升我国心衰诊疗同质化水平[J]. 中国医药科学, 2023, 13(19): 1-6. |
| [9] | 赵颖, 孙跃民, 张文娟, 等. 射血分数正常心力衰竭与射血分数下降心力衰竭的临床特征与预后[J]. 中国慢性病预防与控制, 2012, 20(1): 37-40. |
| [10] | 王煜, 杨莉, 王瑞萍, 等. 慢性心力衰竭与心脏康复[J]. 中国老年保健医学, 2015(1): 94-96. |
| [11] | 王华, 李莹莹, 柴坷, 等. 中国住院心力衰竭患者流行病学及治疗现状[J]. 中华心血管病杂志, 2019, 47(11): 865-874. |
| [12] | 祝德伟, 李秋媛, 杨朴强. 中医药干预慢性心力衰竭机制探讨[J]. 中西医结合心脑血管病杂志, 2022, 20(16): 3045-3047. |
| [13] | 马斌, 雷贺吉, 韩淑伟. 血清肿瘤坏死因子-α、白细胞介素-1β及白细胞介素-6与慢性心力衰竭病人心功能的相关性分析[J]. 中西医结合心脑血管病杂志, 2019, 17(16): 2490-2492. |
