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炎症细胞及乳酸在结直肠癌肝转移中的作用机制
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Abstract:
结直肠癌(Colorectal cancer, CRC)是全球第三大最常见的恶性肿瘤，大约50%的患者在随访期间发生结直肠癌肝转移(Colorectal cancer liver metastasis, CRLM)，肝转移是其最常见的远处转移部位；并且肝转移是结直肠癌患者死亡的主要原因。CRLM的管理最好通过多学科方法实现，诊断和治疗决策过程很复杂。为了优化患者的生存和生活质量，必须克服几个未解决的挑战。这些主要包括及时诊断和确定可靠的预后因素。早期识别结直肠癌肝转移的危险因素可能是降低肝转移发生率的有效策略。炎症细胞及乳酸在肿瘤微环境中发挥着重要作用，对肿瘤细胞转移机制至关重要。本文将探讨炎症细胞及乳酸在结直肠癌异时性肝转移中的作用，这是对手术后发生异时性肝转移的结直肠癌患者进行有效干预的前提，对改善患者生活质量、延长患者生命具有重要意义。
Colorectal cancer (CRC) is the third most common malignant tumor worldwide, and approximately 50% of patients develop colorectal cancer liver metastasis (CRLM) during follow-up, making it the most common distant metastatic site. Liver metastasis is the main cause of death in patients with CRC. The management of CRLM is best achieved through a multidisciplinary approach, and the process of diagnosis and treatment decision-making is complex. To optimize patient survival and quality of life, several unresolved challenges must be overcome. These include the timely diagnosis and the identification of reliable prognostic factors. Early identification of risk factors for CRLM may be an effective strategy to reduce the incidence of liver metastasis. Inflammatory cells and lactic acid play a significant role in the tumor microenvironment and are crucial for the metastatic mechanism of tumor cells. This paper will explore the role of inflammatory cells and lactic acid in the metachronous liver metastasis of colorectal cancer, which is a prerequisite for effective intervention in patients with metachronous liver metastasis of colorectal cancer after surgery, and has important significance for improving patient quality of life and extending patient life.
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