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脾酪氨酸激酶在类风湿关节炎中作用机制的研究进展
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Abstract:
类风湿关节炎(rheumatoid arthritis, RA)是一种以关节滑膜炎症为显著特征的慢性自身免疫系统疾病。其发病复杂且尚未完全阐明。据研究报道，RA越影响全球1%的人群，且发病率呈逐渐上升趋势。但近年来的研究发现脾酪氨酸激酶(Spleen tyrosine kinase, SYK)在RA的发生和发展中起到了关键作用。SYK是一种细胞质非受体型蛋白酪氨酸激酶，广泛存在于多种免疫细胞中，尤其在B细胞、破骨细胞、中性粒细胞和巨噬细胞等免疫细胞中具有重要的生物学功能。因此，本文综述了脾酪氨酸激酶在RA中的研究进展，概述其与RA紧密相关的免疫细胞的相互作用，旨在为探究其在RA发病机制中的作用和研发抗RA靶向药物等提供思路和依据。
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane in the joints, with a complex and yet not fully understood pathogenesis. It is reported that approximately 1% of the global population is affected by RA, and its incidence has been gradually increasing in recent years. Recent studies have highlighted the crucial role of spleen tyrosine kinase (SYK) in the pathogenesis and progression of RA. SYK is a cytoplasmic, non-receptor protein tyrosine kinase, widely expressed in various immune cells, particularly in B cells, osteoclasts, neutrophils, and macrophages, where it plays key biological roles. Therefore, this review summarizes the research progress of SYK in RA, focusing on its interactions with immune cells closely associated with RA. The aim is to provide insights into the role of SYK in the pathogenesis of RA and to support the development of targeted therapies for RA.
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