Background: Pediatric brain tumors (PBT) are among the most common childhood neoplasms worldwide, but their management in low- and middle-income countries (LMICs) remains under-documented. Limited access to specialized care, diagnostic tools, and adjuvant therapies poses significant challenges in sub-Saharan Africa, including Togo. Objective: This study reviews the management of pediatric brain tumors in Togo. Methods: We conducted a retrospective study in the neurosurgery department at Sylvanus Olympio Teaching Hospital between November 2017 and December 2022. Demographic, clinical, radiographic, operative, pathology, and outcome data were collected and analyzed. Results: Eighteen patients had histologically verified brain tumors. Ages ranged from 1 to 15 years (mean: 7.73 ± 4.28), with a sex ratio of 1. Symptoms of raised intracranial pressure were present in 83.4% of cases. The mean interval to presentation was 22 ± 5.32 months. Tumors were supratentorial in 66.7% of cases. Total tumor removal was achieved in 61.1%. Astrocytoma was the most common histological diagnosis, followed by ependymoma and medulloblastoma. Five patients (27.8%) died within the first month post-surgery. The estimated 5-year survival rate was 43% ± 5.4%. Conclusion: Delayed diagnosis, insufficient infrastructure, and limited access to radiotherapy and chemotherapy contribute to poor outcomes. Improving neurosurgical capacity, infrastructure, and financial support could enhance survival and outcomes for pediatric brain tumor patients in Togo.
References
[1]
Stagno, V., Mugamba, J., Ssenyonga, P., Kaaya, B.N. and Warf, B.C. (2013) Presentation, Pathology, and Treatment Outcome of Brain Tumors in 172 Consecutive Children at CURE Children’s Hospital of Uganda. The Predominance of the Visible Diagnosis and the Uncertainties of Epidemiology in Sub-Saharan Africa. Child’s Nervous System, 30, 137-146. https://doi.org/10.1007/s00381-013-2297-z
[2]
Nyalundja, A.D., Kanmounye, U.S., Karekezi, C., Laeke, T., Thango, N. and Balogun, J.A. (2024) Pediatric Brain Tumors in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Journal of Neurosurgery: Pediatrics, 33, 524-535.
[3]
Steliarova-Foucher, E., Colombet, M., Ries, L.A.G., Moreno, F., Dolya, A., Bray, F., et al. (2017) International Incidence of Childhood Cancer, 2001-10: A Population-Based Registry Study. The Lancet Oncology, 18, 719-731.
[4]
Mbi Feh, M.K., Lyon, K.A., Brahmaroutu, A.V., Tadipatri, R. and Fonkem, E. (2021) The Need for a Central Brain Tumor Registry in Africa: A Review of Central Nervous System Tumors in Africa from 1960 to 2017. Neuro-Oncology Practice, 8, 337-344. https://doi.org/10.1093/nop/npaa086
[5]
Ukachukwu, A.K., Still, M.E.H., Seas, A., von Isenburg, M., Fieggen, G., Malomo, A.O., et al. (2023) Fulfilling the Specialist Neurosurgical Workforce Needs in Africa: A Systematic Review and Projection toward 2030. Journal of Neurosurgery, 138, 1102-1113. https://doi.org/10.3171/2022.2.jns211984
[6]
Uche, E.O., Shokunbi, M.T., Malomo, A.O., Akang, E.E.U., Lagunju, I. and Amanor-Boadu, S.D. (2013) Pediatric Brain Tumors in Nigeria: Clinical Profile, Management Strategies, and Outcome. Child’s Nervous System, 29, 1131-1135. https://doi.org/10.1007/s00381-013-2105-9
[7]
Igun, G.O. (2001) Diagnosis and Management of Brain Tumors at Jos University Teaching Hospital, Nigeria. East African Medical Journal, 78, 148-151. https://doi.org/10.4314/eamj.v78i3.9082
[8]
Mehta, V., Chapman, A., McNeely, P.D., Walling, S. and Howes, W.J. (2002) Latency between Symptom Onset and Diagnosis of Pediatric Brain Tumors: An Eastern Canadian Geographic Study. Neurosurgery, 51, 365-373. https://doi.org/10.1097/00006123-200208000-00012
[9]
Elhassan, M.M.A., Mohamedani, A.A., Osman, H.H.M., Yousif, N.O., Elhaj, N.M. and Qaddoumi, I. (2019) Patterns, Treatments, and Outcomes of Pediatric Central Nervous System Tumors in Sudan: A Single Institution Experience. Child’s Nervous System, 35, 437-444. https://doi.org/10.1007/s00381-018-04032-9
[10]
Dewan, M.C., Rattani, A., Fieggen, G., Arraez, M.A., Servadei, F., Boop, F.A., et al. (2019) Global Neurosurgery: The Current Capacity and Deficit in the Provision of Essential Neurosurgical Care. Executive Summary of the Global Neurosurgery Initiative at the Program in Global Surgery and Social Change. Journal of Neurosurgery, 130, 1055-1064. https://doi.org/10.3171/2017.11.jns171500
[11]
Uche, E.O., Eke, C.B., Okafor, O.C., Uche, N.J., Ajuzieogu, O.V., Amuta, D.S., et al. (2020) Pediatric Brain Tumor Care in a Sub-Saharan Setting: Current Poise of a Precariously Loaded Dice. British Journal of Neurosurgery, 35, 174-180. https://doi.org/10.1080/02688697.2020.1777259
[12]
McGirt, M.J., Chaichana, K.L., Attenello, F.J., Weingart, J.D., Than, K., Burger, P.C., et al. (2008) Extent of Surgical Resection Is Independently Associated with Survival in Patients with Hemispheric Infiltrating Low-Grade Gliomas. Neurosurgery, 63, 700-708. https://doi.org/10.1227/01.neu.0000325729.41085.73
[13]
Vabulas, M., Kumar, V.A., Hamilton, J.D., Martinez, J.J., Rao, G., Sawaya, R., et al. (2014) Real-Time Atlas-Based Stereotactic Neuronavigation. Neurosurgery, 74, 128-134. https://doi.org/10.1227/neu.0000000000000199
[14]
Khalil, E.M. (2008) Treatment Results of Adults and Children with Medulloblastoma NCI, Cairo University Experience. Journal of the Egyptian National Cancer Institute, 20, 175-186.
[15]
Ostrom, Q.T., Francis, S.S. and Barnholtz-Sloan, J.S. (2021) Epidemiology of Brain and Other CNS Tumors. Current Neurology and Neuroscience Reports, 21, Article No. 68. https://doi.org/10.1007/s11910-021-01152-9
[16]
Abuhamed, J., Nikkilä, A., Raitanen, J., Alimam, W., Lohi, O., Pitkäniemi, J., et al. (2022) Incidence Trends of Childhood Central Nervous System Tumors in Finland 1990-2017. BMC Cancer, 22, Article No. 784. https://doi.org/10.1186/s12885-022-09862-0
[17]
Kaatsch, P., Rickert, C.H., Kühl, J., Schüz, J. and Michaelis, J. (2001) Population-based Epidemiologic Data on Brain Tumors in German Children. Cancer, 92, 3155-3164. https://doi.org/10.1002/1097-0142(20011215)92:12<3155::aid-cncr10158>3.0.co;2-c
[18]
Bellil, S., Limaiem, F., Mahfoudhi, H., Bellil, K., Chelly, I., Mekni, A., et al. (2008) Descriptive Epidemiology of Childhood Central Nervous System Tumours in Tunisia. Pediatric Neurosurgery, 44, 382-387. https://doi.org/10.1159/000149905