|
|
失眠障碍患者脑网络机制研究进展
|
Abstract:
失眠障碍是一种严重影响身心健康的常见慢性疾病，主要症状包括入睡困难、睡眠维持困难和早醒等。目前磁共振成像在失眠障碍中广泛应用。故本综述旨在通过整合现有已发表的研究报道，阐明失眠障碍患者脑网络功能的异常，以及未来研究应进一步探索脑网络异常与失眠障碍的关系，为深入理解失眠障碍的发病机制以及开发新的治疗策略提供理论依据。
Insomnia disorder is a common chronic disease that severely affects physical and mental health, with main symptoms including difficulty falling asleep, difficulty maintaining sleep, and early awakening. Magnetic resonance imaging is widely used in the study of insomnia disorder. Therefore, this review aims to integrate existing published research reports to clarify the abnormalities in brain network function in patients with insomnia disorder, and future studies should further explore the relationship between brain network abnormalities and insomnia disorder, providing a theoretical basis for a deeper understanding of the pathogenesis of insomnia disorder and the development of new therapeutic strategies.
| [1] | 王玉平. 中国成人失眠诊断与治疗指南(2023版) [J]. 中华神经科杂志, 2024, 57(6): 560-584. |
| [2] | Rosenberg, R.P. (2021) Prevalence, Impact, and Burden of Insomnia and Discussing It with Patients. The Journal of Clinical Psychiatry, 82, EI20008BR1C. https://doi.org/10.4088/jcp.ei20008br1c |
| [3] | Khan, M.S. and Aouad, R. (2022) The Effects of Insomnia and Sleep Loss on Cardiovascular Disease. Sleep Medicine Clinics, 17, 193-203. https://doi.org/10.1016/j.jsmc.2022.02.008 |
| [4] | Olaithe, M., Ree, M., McArdle, N., Donaldson, S., Pushpanathan, M., Eastwood, P.R., et al. (2021) Cognitive Dysfunction in Insomnia Phenotypes: Further Evidence for Different Disorders. Frontiers in Psychiatry, 12, Article 688672. https://doi.org/10.3389/fpsyt.2021.688672 |
| [5] | Kjørstad, K., Sivertsen, B., Vedaa, Ø., Langsrud, K., Faaland, P.M., Vethe, D., et al. (2020) The Effect of Reducing Insomnia Severity on Work and Activity-Related Impairment. Behavioral Sleep Medicine, 19, 505-515. https://doi.org/10.1080/15402002.2020.1799792 |
| [6] | Brossoit, R.M., Crain, T.L., Leslie, J.J., Hammer, L.B., Truxillo, D.M. and Bodner, T.E. (2019) The Effects of Sleep on Workplace Cognitive Failure and Safety. Journal of Occupational Health Psychology, 24, 411-422. https://doi.org/10.1037/ocp0000139 |
| [7] | Morin, C.M., Altena, E., Ivers, H., Mérette, C., LeBlanc, M., Savard, J., et al. (2020) Insomnia, Hypnotic Use, and Road Collisions: A Population-Based, 5-Year Cohort Study. Sleep, 43, zsaa032. https://doi.org/10.1093/sleep/zsaa032 |
| [8] | Raimondo, L., Oliveira, ĺ.A.F., Heij, J., Priovoulos, N., Kundu, P., Leoni, R.F., et al. (2021) Advances in Resting State fMRI Acquisitions for Functional Connectomics. NeuroImage, 243, Article 118503. https://doi.org/10.1016/j.neuroimage.2021.118503 |
| [9] | 左美美, 韩彦青. 静息态功能磁共振不同分析方法在血管性认知障碍中的应用[J]. 世界最新医学信息文摘, 2018, 18(34): 110-114. |
| [10] | Zuo, X., Di Martino, A., Kelly, C., Shehzad, Z.E., Gee, D.G., Klein, D.F., et al. (2010) The Oscillating Brain: Complex and Reliable. NeuroImage, 49, 1432-1445. https://doi.org/10.1016/j.neuroimage.2009.09.037 |
| [11] | Yuan, L., Wang, J., Zhao, N., Li, Y., Ma, Y., Liu, D., et al. (2018) Intra and Inter-Scanner Reliability of Scaled Subprofile Model of Principal Component Analysis on ALFF in Resting-State fMRI under Eyes Open and Closed Conditions. Frontiers in Neuroscience, 12, Article 311. https://doi.org/10.3389/fnins.2018.00311 |
| [12] | Riedl, V., Bienkowska, K., Strobel, C., Tahmasian, M., Grimmer, T., Förster, S., et al. (2014) Local Activity Determines Functional Connectivity in the Resting Human Brain: A Simultaneous FDG-PET/fMRI Study. The Journal of Neuroscience, 34, 6260-6266. https://doi.org/10.1523/jneurosci.0492-14.2014 |
| [13] | Fu, X., Li, H., Yan, M., Chen, J., Liu, F., Zhao, J., et al. (2021) Shared and Distinct Fractional Amplitude of Low-Frequency Fluctuation Patterns in Major Depressive Disorders with and without Gastrointestinal Symptoms. Frontiers in Psychiatry, 12, Article 744898. https://doi.org/10.3389/fpsyt.2021.744898 |
| [14] | He, J., Jia, B., Wang, Y., Li, S., Zhao, B., Zhou, Z., et al. (2022) Transcutaneous Auricular Vagus Nerve Stimulation Modulates the Prefrontal Cortex in Chronic Insomnia Patients: fMRI Study in the First Session. Frontiers in Neurology, 13, Article 827749. https://doi.org/10.3389/fneur.2022.827749 |
| [15] | Tripathi, V. and Garg, R. (2022) Weak Task Synchronization of Default Mode Network in Task Based Paradigms. NeuroImage, 251, Article 118940. https://doi.org/10.1016/j.neuroimage.2022.118940 |
| [16] | Raichle, M.E. (2015) The Brain’s Default Mode Network. Annual Review of Neuroscience, 38, 433-447. https://doi.org/10.1146/annurev-neuro-071013-014030 |
| [17] | Andrews-Hanna, J.R., Smallwood, J. and Spreng, R.N. (2014) The Default Network and Self-Generated Thought: Component Processes, Dynamic Control, and Clinical Relevance. Annals of the New York Academy of Sciences, 1316, 29-52. https://doi.org/10.1111/nyas.12360 |
| [18] | Xia, G., Hu, Y., Chai, F., Wang, Y. and Liu, X. (2022) Abnormalities of the Default Mode Network Functional Connectivity in Patients with Insomnia Disorder. Contrast Media & Molecular Imaging, 2022, Article 9197858. https://doi.org/10.1155/2022/9197858 |
| [19] | Killgore, W.D.S., Jankowski, S., Henderson-Arredondo, K., Lucas, D.A., Patel, S.I., Hildebrand, L.L., et al. (2023) Functional Connectivity of the Default Mode Network Predicts Subsequent Polysomnographically Measured Sleep in People with Symptoms of Insomnia. NeuroReport, 34, 734-740. https://doi.org/10.1097/wnr.0000000000001949 |
| [20] | 胡永雪, 夏光源, 时靖宇, 等. 失眠症患者静息态功能磁共振脑默认网络功能连接分析[J]. 中华行为医学与脑科学杂志, 2021, 30(3): 206-212. |
| [21] | Elberse, J.D., Saberi, A., Ahmadi, R., Changizi, M., Bi, H., Hoffstaedter, F., et al. (2024) The Interplay between Insomnia Symptoms and Alzheimer’s Disease across Three Main Brain Networks. SLEEP, 47, zsae145. https://doi.org/10.1093/sleep/zsae145 |
| [22] | Yao, L., Wang, Y., Gao, Y., Gao, H. and Guo, X. (2023) The Role of the Fronto-Parietal Network in Modulating Sustained Attention under Sleep Deprivation: An Functional Magnetic Resonance Imaging Study. Frontiers in Psychiatry, 14, Article 1289300. https://doi.org/10.3389/fpsyt.2023.1289300 |
| [23] | He, Q., Zheng, H., Zhang, J., Yue, L., Kang, Q., Lian, C., et al. (2024) Association between the Frontoparietal Network, Clinical Symptoms and Treatment Response in Individuals with Untreated Anorexia Nervosa. General Psychiatry, 37, e101389. https://doi.org/10.1136/gpsych-2023-101389 |
| [24] | Cui, W., Zhang, S., Xu, F., Li, H., Zhi, H., Wang, Y., et al. (2022) A Resting-State Functional Magnetic Resonance Imaging Study of Abnormal Frontoparietal Network Function in Migraine without Aura. Medical Science Monitor, 28, e934975. https://doi.org/10.12659/msm.934975 |
| [25] | Chen, W., Wang, H., Sun, T., Wu, Q., Han, W., Li, Q., et al. (2022) Dynamic Changes in Fractional Amplitude of Low-Frequency Fluctuations in Patients with Chronic Insomnia. Frontiers in Neuroscience, 16, Article 1050240. https://doi.org/10.3389/fnins.2022.1050240 |
| [26] | Dai, C., Zhang, Y., Cai, X., Peng, Z., Zhang, L., Shao, Y., et al. (2020) Effects of Sleep Deprivation on Working Memory: Change in Functional Connectivity between the Dorsal Attention, Default Mode, and Fronto-Parietal Networks. Frontiers in Human Neuroscience, 14, Article 360. https://doi.org/10.3389/fnhum.2020.00360 |
| [27] | Yin, X., Jiang, T., Song, Z., Zhu, L., Wang, G. and Guo, J. (2024) Increased Functional Connectivity within the Salience Network in Patients with Insomnia. Sleep and Breathing, 28, 1261-1271. https://doi.org/10.1007/s11325-024-03002-7 |
| [28] | Khazaie, H., Veronese, M., Noori, K., Emamian, F., Zarei, M., Ashkan, K., et al. (2017) Functional Reorganization in Obstructive Sleep Apnoea and Insomnia: A Systematic Review of the Resting-State fMRI. Neuroscience & Biobehavioral Reviews, 77, 219-231. https://doi.org/10.1016/j.neubiorev.2017.03.013 |
| [29] | Sfera, A., Thomas, K.A., Ogunjale, I.A., Jafri, N. and Bota, P.G. (2024) Insomnia in Forensic Detainees: Is Salience Network the Common Pathway for Sleep, Neuropsychiatric, and Neurodegenerative Disorders? Journal of Clinical Medicine, 13, Article 1691. https://doi.org/10.3390/jcm13061691 |
| [30] | Liu, C., Guo, J., Lu, S., Tang, L., Fan, J., Wang, C., et al. (2018) Increased Salience Network Activity in Patients with Insomnia Complaints in Major Depressive Disorder. Frontiers in Psychiatry, 9, Article 93. https://doi.org/10.3389/fpsyt.2018.00093 |
| [31] | Perlis, M.L., Posner, D., Riemann, D., Bastien, C.H., Teel, J. and Thase, M. (2022) Insomnia. The Lancet, 400, 1047-1060. https://doi.org/10.1016/s0140-6736(22)00879-0 |
| [32] | Schimmelpfennig, J., Topczewski, J., Zajkowski, W. and Jankowiak-Siuda, K. (2023) The Role of the Salience Network in Cognitive and Affective Deficits. Frontiers in Human Neuroscience, 17, Article 1133367. https://doi.org/10.3389/fnhum.2023.1133367 |
| [33] | Li, C., Dong, M., Yin, Y., Hua, K., Fu, S. and Jiang, G. (2017) Abnormal Whole-Brain Functional Connectivity in Patients with Primary Insomnia. Neuropsychiatric Disease and Treatment, 13, 427-435. https://doi.org/10.2147/ndt.s128811 |
| [34] | Regen, W., Kyle, S.D., Nissen, C., Feige, B., Baglioni, C., Hennig, J., et al. (2016) Objective Sleep Disturbances Are Associated with Greater Waking Resting-State Connectivity between the Retrosplenial Cortex/Hippocampus and Various Nodes of the Default Mode Network. Journal of Psychiatry and Neuroscience, 41, 295-303. https://doi.org/10.1503/jpn.140290 |
| [35] | Allan, P.G., Briggs, R.G., Conner, A.K., O'Neal, C.M., Bonney, P.A., Maxwell, B.D., et al. (2019) Parcellation-Based Tractographic Modeling of the Dorsal Attention Network. Brain and Behavior, 9, e01365. https://doi.org/10.1002/brb3.1365 |
| [36] | Abdolalizadeh, A. and Nabavi, S. (2022) Visual Attention and Poor Sleep Quality. Frontiers in Neuroscience, 16, Article 850372. https://doi.org/10.3389/fnins.2022.850372 |
| [37] | Dixon, M.L., Andrews-Hanna, J.R., Spreng, R.N., Irving, Z.C., Mills, C., Girn, M., et al. (2017) Interactions between the Default Network and Dorsal Attention Network Vary across Default Subsystems, Time, and Cognitive States. NeuroImage, 147, 632-649. https://doi.org/10.1016/j.neuroimage.2016.12.073 |
| [38] | Owens, M.M., Yuan, D., Hahn, S., Albaugh, M., Allgaier, N., Chaarani, B., et al. (2020) Investigation of Psychiatric and Neuropsychological Correlates of Default Mode Network and Dorsal Attention Network Anticorrelation in Children. Cerebral Cortex, 30, 6083-6096. https://doi.org/10.1093/cercor/bhaa143 |
| [39] | Wang, J., Xu, Y., Deshpande, G., Li, K., Sun, P. and Liang, P. (2021) The Effect of Light Sedation with Midazolam on Functional Connectivity of the Dorsal Attention Network. Brain Sciences, 11, Article 1107. https://doi.org/10.3390/brainsci11081107 |
| [40] | Alsameen, M., DiFrancesco, M.W., Drummond, S.P.A., Franzen, P.L. and Beebe, D.W. (2021) Neuronal Activation and Performance Changes in Working Memory Induced by Chronic Sleep Restriction in Adolescents. Journal of Sleep Research, 30, e13304. https://doi.org/10.1111/jsr.13304 |
| [41] | Xu, Z., Zhao, W., Wang, H., Tian, Y. and Lei, X. (2023) Functional Connectivity between Dorsal Attention and Default Mode Networks Mediates Subjective Sleep Duration and Depression in Young Females. Journal of Affective Disorders, 325, 386-391. https://doi.org/10.1016/j.jad.2023.01.023 |
