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C反应蛋白–白蛋白–淋巴细胞(CALLY)指数对皮肌炎患者间质性肺病和疾病活动度的预测价值
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Abstract:
背景：C反应蛋白–白蛋白–淋巴细胞(CALLY)指数在具有免疫过程的疾病中显示出良好的前景。然而，有关其在皮肌炎中的应用的研究还很有限。这项回顾性研究旨在评估CALLY对皮肌炎患者的间质性肺病和疾病活动度的预测价值。方法：我们收集了105位皮肌炎患者(45位患有间质性肺炎，60位无间质性肺炎)和102名健康对照者的临床数据。从电子医疗记录中提取临床特征，采用二元逻辑回归和ROC曲线分析CALLY、临床特征和疾病活动度之间的相关性。结果：皮肌炎患者的CALLY水平明显低于对照组(P < 0.001)。在皮肌炎组中，间质性肺炎患者的CALLY水平明显低于非间质性肺炎患者(P < 0.05)。CALLY与VAS总分呈负相关(r = ？0.305, P = 0.002)。ROC分析确定预测皮肌炎患者无ILD的最佳CALLY临界值为8.41 (敏感性91.1%，特异性40%，曲线下面积 = 0.620)。Logistic回归分析确定CALLY (p = 0.005)是无间质性肺炎的皮肌炎的独立预测指标。结论：CALLY与DM患者的不合并间质性肺炎和疾病活动度降低有明显相关性，这表明它在DM的评估和监测方面具有一定潜力。
Background: The C-reactive protein-albumin-lymphocyte (CALLY) index has demonstrated potential in assessing diseases with immunological processes. However, investigations into its applicability in dermatomyositis (DM) remain limited. This retrospective study aims to assess the predictive value of the CALLY index for interstitial lung disease and disease activity in patients with dermatomyositis. Methods: Data from 105 patients with DM (45 with interstitial lung disease [ILD], 60 without ILD) and 102 healthy controls were collected. Relevant clinical characteristics were extracted from medical records. Logistic regression and receiver operating characteristic (ROC) curve analyses were employed to examine correlations among CALLY, clinical characteristics, and disease activity. Results: Patients with DM demonstrated significantly lower CALLY values compared to controls (P < 0.001). Within the DM cohort, patients with ILD exhibited significantly lower CALLY values than those without ILD (P <0.05). CALLY showed a negative correlation with the global Visual Analogue Scale (VAS) score (r = ？0.305, P = 0.002). ROC analysis determined the optimal CALLY cutoff value for predicting non-ILD in DM patients to be 8.41 (sensitivity 91.1%, specificity 40%, area under the ROC curve = 0.620). CALLY (P = 0.005) was identified as an independent predictor of DM without concurrent ILD. Conclusions: The CALLY index demonstrated a significant association with the absence of interstitial lung disease and reduced disease activity in patients with DM, indicating its potential utility in the assessment and monitoring of dermatomyositis.
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