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抑郁障碍患者情绪调节相关脑区的静息态磁共振成像研究进展
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Abstract:
抑郁障碍是一种以显著而持久的心境低落为主要特征的精神障碍，临床表现多种多样，与患者的社会功能及生活质量密切相关。目前，抑郁障碍的病因尚不清楚，已有研究表明遗传因素、神经生化因素、内分泌及代谢异常、社会心理因素、性格特征及文化背景等均可能参与抑郁障碍的发病过程。脑影像学技术能够观察脑结构、功能及代谢网络的动态变化，通过研究脑结构与功能之间的相互关系，从而对抑郁障碍患者的认知和情绪异常进行客观评价。本文就抑郁障碍患者情绪调节相关脑区磁共振成像研究进展进行综述，旨在为抑郁障碍的神经生物学机制研究提供新思路，为抑郁障碍患者提供更精准的生物标志物。
Major depressive disorder is a mental disorder characterized by significant and persistent low mood, with a variety of clinical manifestations that are closely related to the patient’s social functioning and quality of life. Currently, the etiology of major depressive disorder is not yet clear. Existing studies have shown that genetic factors, neurobiochemical factors, endocrine and metabolic abnormalities, social and psychological factors, personality traits, and cultural background may all contribute to the pathogenesis of major depressive disorder. Brain imaging techniques can observe the dynamic changes in brain structure, function, and metabolic networks. By studying the interrelationship between brain structure and function, they provide an objective evaluation of cognitive and emotional abnormalities in patients with major depressive disorder. This article reviews the research progress on magnetic resonance imaging of brain regions related to emotion regulation in patients with major depressive disorder, aiming to provide new insights into the neurobiological mechanisms of major depressive disorder and to offer more precise biomarkers for patients with major depressive disorder.
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