风湿免疫病患者中免疫球蛋白水平与年龄相关性分析
Analysis of the Correlation between Immunoglobulin Levels and Age in Patients with Rheumatic Immune Diseases

目的：旨在研究风湿免疫病患者不同年龄组间血清免疫球蛋白(IgG, IgA, IgM)的含量特点。方法：选取2023年1月至2023年12月就诊于泰安中心医院风湿免疫科门诊及住院患者的病历资料共13,949例。统计其IgM、IgG、IgA值进行相关性分析，结果：对于IgG，三个年龄组的平均值分别为9.406、12.211、12.436，表明IgG水平随年龄增长呈上升趋势(F = 735.069, P < 0.001)。对IgM的分析结果显示1~30岁组的平均值最高(1.164)，而60岁以上组最低(1.034) (F = 16.113, P < 0.001)，IgA的平均值在>60岁组及31~60岁组显著高于1~30岁组，分别为2.751、2.69和1.205 (F = 1097.913, P < 0.001)，随着年龄衰老IgA水平升高。结论：免疫球蛋白水平与风湿免疫病患者的年龄老化之间存在着一定的关联性。
Objective: To investigate the content of immunoglobulin (IgG, IgA, IgM) in serum of patients with rheumatic immune diseases in different age groups and between adult men and women. Methods: A total of 13,949 outpatients and inpatients in the Department of Rheumatology and Immunology of Tai’an Central Hospital, Qingdao University from January 2023 to December 2023 were enrolled. Results: For IgG, the mean values of the three age groups were 9.406, 12.211 and 12.436, respectively, indicating that the IgG level showed an upward trend with age (F = 735.069, P < 0.001). The results of IgM analysis showed that the average value of IgM was the highest in the 1~30 years old group (1.164), and the lowest in the group over 60 years old (1.034) (F = 16.113, P < 0.001).The average value of IgA in >the 60-year-old group and the 31~60 years old group was significantly higher than that in the 1~30 years old group, which were 2.751, 2.69 and 1.205 (F = 1097.913, P < 0.001), respectively, and the level of IgA increased with aging. Conclusion: There is a certain relationship between immunoglobulin level and age in patients with rheumatic immune diseases.