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m6A甲基化修饰的lncRNA对消化道肿瘤的作用
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Abstract:
m6A甲基化是mRNA和lncRNA等RNA分子中的一种重要表观遗传修饰，通过调控基因表达，在消化道肿瘤的发生和发展中发挥重要作用。m6A甲基化修饰的lncRNA对多种消化道肿瘤如肝癌、胃癌、食管癌和胰腺癌的增殖、侵袭及转移有显著影响。在消化道肿瘤的诊断、治疗和预后评估中，m6A修饰的lncRNA作为生物标志物具有广泛应用潜力。未来的研究有望将这一修饰机制转化为临床治疗靶点，提升患者生存率和治疗效果。
m6A methylation is an important epigenetic modification in RNA molecules such as mRNA and lncRNA, which plays an important role in the occurrence and development of gastrointestinal tumors by regulating gene expression. m6A methylation-modified lncRNA has a significant impact on the proliferation, invasion, and metastasis of a variety of gastrointestinal tract tumors such as hepatocellular carcinomas, gastric carcinomas, esophageal carcinomas, and pancreatic carcinomas. The m6A-modified lncRNA has a wide potential for use as biomarkers in the diagnosis, treatment and prognosis evaluation of GI tumors. Future studies are expected to translate this modification mechanism into clinical therapeutic targets to enhance patient survival and treatment effects.
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