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CYP19A1在消化道肿瘤中的研究进展
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Abstract:
消化道肿瘤是我国最常见的恶性肿瘤，发病率和死亡率均居高位，严重威胁人们的身体健康，亟需寻找有效的诊断方法和治疗靶点。CYP19A1属于细胞色素P450家族的成员，定位于内质网，是将雄激素构化为雌激素的关键限速酶，在不同组织中发挥不同的作用以维持重要的组织特异性功能。近年来的研究发现，CYP19A1在胃癌、结直肠癌等恶性消化道肿瘤中异常表达并促进肿瘤的进展。然而，CYP19A1在消化道肿瘤中的具体调控机制尚不明确。因此，本文对近年相关研究进行综述，以表明CYP19A1在消化道肿瘤生长过程中存在潜在的研究价值，对于靶向CYP19A1诠释消化道肿瘤的生长机制、预后预测以及靶向治疗等方面具有重要意义。
Gastrointestinal tumors are the most prevalent malignant tumors in China, featuring high morbidity and mortality rates, seriously threatening people’s physical health. There is an urgent need to discover effective diagnostic approaches and therapeutic targets. Aromatase (CYP19A1), a member of the cytochrome P450 family, is located in the endoplasmic reticulum and serves as the key rate-limiting enzyme that converts androgens into estrogens, exerting diverse functions in different tissues to maintain crucial tissue-specific functions. Recent studies have revealed that CYP19A1 is aberrantly expressed in malignant gastrointestinal tumors such as gastric cancer and colorectal cancer and promotes tumor progression. Nevertheless, the specific mechanism underlying CYP19A1 in gastrointestinal tumors remains unclear. Thus, this article conducts a review of the relevant research in recent years to indicate the potential research value of CYP19A1 in the growth process of gastrointestinal tumors, which is of significant importance for interpreting the growth mechanism, prognosis prediction, and targeted therapy of gastrointestinal tumors by targeting CYP19A1.
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