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细胞自噬调控在肝细胞癌多领域综合治疗中的作用研究进展
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Abstract:
肝细胞癌(Hepatocellular carcinoma, HCC)是全球范围内最常见的恶性肿瘤之一，慢性肝炎、吸烟、肝硬化以及分子过程的改变都可以导致肝细胞癌的发展。肝细胞癌的治疗手段包括基因治疗、中药治疗、化疗药物以及其他许多途径的治疗，近年来，HCC的综合治疗取得了显著进展。自噬是一种细胞自我消化的过程，对于维持细胞内稳态和代谢平衡至关重要。在肝细胞癌的治疗中，自噬的调节成为了一个潜在靶点，其可以对肿瘤的治疗产生细胞保护性和细胞毒性的双重影响，自噬的调节可能通过氧化应激、肿瘤免疫以及维持稳态等方面影响肝细胞癌的发生发展。在本文中，我们综合阐述了自噬在肝细胞癌的综合治疗方法中所发挥的作用，为优化肝细胞癌的治疗效果以及实现个体化治疗从而提升患者的预后以及生存质量提供了一些策略。
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Chronic hepatitis, smoking, cirrhosis and molecular process can lead to the development of HCC. The treatment of hepatocellular carcinoma includes gene therapy, traditional Chinese medicine therapy, chemotherapy drugs and many other ways. In recent years, the comprehensive treatment of HCC has made significant progress. Autophagy is a process of cellular self-digestion that is essential for maintaining cellular homeostasis and metabolic balance. In the treatment of HCC, the regulation of autophagy becomes a potential target, which can produce both cytoprotective and cytotoxic effects on the treatment of tumors. The regulation of autophagy may affect the development of HCC through oxidative stress, tumor immunity and maintenance of homeostasis. In this paper, we comprehensively illustrate the role of autophagy in the comprehensive treatment of HCC, and provide some strategies to optimize the therapeutic effect of HCC and realize individualized treatment to improve patient prognosis and quality of life.
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