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Pharmacy Information 2025
蛇含委陵菜化学成分及药理活性研究进展
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Abstract:
蛇含委陵菜(Potentilla kleiniana Wight et Arn.)是贵州特色抗炎民族药材，在贵州苗族、布依族及侗族等少数名族地区，常将其用于乳腺炎、风湿性关节炎等疾病。其主要的化学成分为木脂素类、萜类、氨基酸及其衍生物类、黄酮类、酚类、生物碱和有机酸等，具有抗炎、降血糖、抑菌、抗肿瘤、抗疟疾和抗病毒等药理作用。本文对近年来蛇含委陵菜化学成分和药理活性的研究进行了系统的综述，旨在为蛇含委陵菜的进一步开发利用提供参考。
Potentilla kleiniana Wight et Arn. is a characteristic ethnic medicinal material in Guizhou, and is often used for diseases of mastitis and rheumatoid arthritis in minority ethnic areas such as Miao, Buyi and Dong in Guizhou. Its main chemical components include lignins, terpenoids, amino acids and their derivatives, flavonoids, phenols, alkaloids, organic acids, etc., with pharmacological activities including anti-inflammatory, hypoglycemic, antibacterial, anti-tumor, antimalarial, antiviral. This work provides a systematic review of the research on the chemical constituents and pharmacological activities of Potentilla kleiniana Wight et Arn. in recent years, aiming to provide a reference for the further development and utilization of Potentilla kleiniana Wight et Arn.
| [1] | 陈鹏飞, 曾兰芳, 唐宜芳, 等. 五皮草的生药学研究[J]. 大理学院学报, 2014, 13(10): 22-24. |
| [2] | 张晨光, 周晶, 王珊, 等. 蛇含委陵菜乙醇提取物的抗炎及抑菌活性研究[J]. 中南药学, 2018, 16(11): 1547-1552. |
| [3] | 张宝, 刘佳, 匡维米, 等. 蛇含委陵菜的化学成分及抗炎活性研究[J]. 广西植物, 2023, 43(11): 2149-2158. |
| [4] | 李胜华, 伍贤进, 曾军英, 等. 蛇含委陵菜总黄酮的体外和体内降血糖效果研究[J]. 食品科学, 2014, 35(11): 246-250. |
| [5] | 张宝, 金倩倩, 陈婷婷, 等. 蛇含委陵菜的三萜类成分及其细胞毒活性研究[J]. 广西植物, 2023, 45(11): 1101-1222. |
| [6] | 吴嘉, 张在其, 余黄合, 等. 委陵菜属植物的化学成分及药理作用研究进展[J]. 中国中药杂志, 2022, 47(6): 1509-1538. |
| [7] | 张宝, 杨红, 匡维米, 等. 蛇含委陵菜的木脂素类成分及其细胞毒活性研究[J]. 广西植物, 2024, 44(6): 1082-1090. |
| [8] | 李胜华, 伍贤进, 牛友芽, 等. 蛇含委陵菜化学成分研究[J]. 中草药, 2011, 42(11): 2200-2203. |
| [9] | Tang, Y., Yu, P. and Chen, L. (2023) Identification of Antibacterial Components and Modes in the Methanol-Phase Extract from a Herbal Plant Potentilla Kleiniana Wight et Arn. Foods, 12, Article 1640. https://doi.org/10.3390/foods12081640 |
| [10] | 张宝, 李悦, 陈婷婷, 等. 基于UPLC-Q-Exactive-Plus-Orbitrap-MS技术分析蛇含委陵菜的化学成分[J]. 中药材, 2023, 46(12): 3014-3022. |
| [11] | 黄易安, 黄思菊, 国兴明. 蛇含委陵菜提取物抑菌作用的研究[J]. 贵州大学学报(自然科学版), 2008, 25(3): 320-321. |
| [12] | 周志远, 卢群, 刘洋, 等. 豆甾醇的研究及开发进展[J]. 中国当代医药, 2015, 22(24): 15-17. |
| [13] | 陈元堃, 曾奥, 罗振辉, 等. β-谷甾醇药理作用研究进展[J]. 广东药科大学学报, 2021, 37(1): 148-153. |
| [14] | 刘峻. 新穿心莲内酯对体外活化小鼠巨噬细胞的影响[J]. 中国天然药物, 2005, 3(5): 308-311. |
| [15] | 张彤, 张宇, 王诗浓, 等. 异荭草素抗肿瘤药理作用及其机制的研究[J]. 畜牧与饲料科学, 2019, 40(9): 86-88. |
| [16] | Liu, M., Huang, X., Liu, Q., Li, X., Chen, M., Zhu, Y., et al. (2019) Separation of α-Glucosidase Inhibitors from Potentilla Kleiniana Wight Et Arn Using Solvent and Flow-Rate Gradient High-Speed Counter-Current Chromatography Target-Guided by Ultrafiltration HPLC-MS Screening. Phytochemical Analysis, 30, 661-668. https://doi.org/10.1002/pca.2839 |
| [17] | 闫科润, 沈玥, 李宁, 等. 异荭草素调控糖尿病的作用机制研究进展[J]. 食品与发酵工业, 2022, 48(22): 338-344. |
| [18] | Li, S., Tan, J., Zeng, J., et al. (2017) Antihyperglycemic and Antioxidant Effect of the Total Flavones of Potentilla kleiniana Wight et Arn. in Streptozotocin Induced Diabetic Rats. Pakistan Journal of Pharmaceutical Sciences, 30, 171-178. |
| [19] | Tao, J., Yan, S., Zhou, C., Liu, Q., Zhu, H. and Wen, Z. (2021) Total Flavonoids from Potentilla kleiniana Wight et Arn Inhibits Biofilm Formation and Virulence Factors Production in Methicillin-Resistant Staphylococcus Aureus (MRSA). Journal of Ethnopharmacology, 279, Article 114383. https://doi.org/10.1016/j.jep.2021.114383 |
| [20] | 黄易安. 蛇含委陵菜化学成分及抑菌活性研究[D]: [硕士学位论文]. 贵阳: 贵州大学, 2008. |
| [21] | 陶俊宇, 胡庭俊, 班丽萍. 蛇含委陵菜提取物对人工感染鸡白痢的治疗效果[J]. 南方农业学报, 2012, 43(9): 1391-1394. |
| [22] | 贺海波, 朱丽金, 贺君宇, 等. 委陵菜酸对幽门螺杆菌诱导GES-1细胞损伤的保护作用[J]. 中草药, 2021, 52(16): 4892-4903. |
| [23] | Zhou, Y.Q., Li, S.M., Wei, X., Yang, X., Xiao, J.W., Pan, B.W., et al. (2022) Identification and Quantitative Analysis of Bioactive Components from Potentilla kleiniana Wight et Arn with Anti HIV-1 Proteases Activity. Natural Product Research, 37, 4028-4031. https://doi.org/10.1080/14786419.2022.2162513 |
| [24] | 付千. 鞣花酸对马兜铃酸Ⅰ诱导急性肾损伤的保护作用及其机制研究[D]: [硕士学位论文]. 武汉: 中南民族大学, 2020. |
| [25] | 刘蒲, 王国权. 五环三萜类化合物的药理作用研究进展[J]. 海峡药学, 2018, 30(10): 1-6. |
| [26] | Kim, B., Kim, J. and Park, B. (2015) Pomolic Acid Inhibits Invasion of Breast Cancer Cells through the Suppression of CXC Chemokine Receptor Type 4 Expression. Journal of Cellular Biochemistry, 117, 1296-1307. https://doi.org/10.1002/jcb.25417 |
| [27] | Oprean, C., Mioc, M., Csányi, E., Ambrus, R., Bojin, F., Tatu, C., et al. (2016) Improvement of Ursolic and Oleanolic Acids’ Antitumor Activity by Complexation with Hydrophilic Cyclodextrins. Biomedicine & Pharmacotherapy, 83, 1095-1104. https://doi.org/10.1016/j.biopha.2016.08.030 |
| [28] | 于婷婷. 熊果酸衍生物的合成及抗肿瘤活性研究[D]: [硕士学位论文]. 沈阳: 沈阳化工大学, 2018. |
| [29] | 聂龙, 彭磊, 李钰芳, 等. 紫云英苷生物活性及其机制的研究进展[J]. 热带农业科学, 2020, 40(6): 64-70. |
| [30] | Simirgiotis, M., Schmeda-Hirschmann, G., Bórquez, J. and Kennelly, E. (2013) The Passiflora Tripartita (Banana Passion) Fruit: A Source of Bioactive Flavonoid C-Glycosides Isolated by HSCCC and Characterized by HPLC-DAD-ESI/MS/MS. Molecules, 18, 1672-1692. https://doi.org/10.3390/molecules18021672 |
| [31] | Lin, Y., Chen, T., Tseng, H., Lee, M. and Chen, S. (2009) Neural Cell Protective Compounds Isolated from Phoenix Hanceana Var. Formosana. Phytochemistry, 70, 1173-1181. https://doi.org/10.1016/j.phytochem.2009.06.006 |
| [32] | Kim, J., Lee, I., Seo, J., Jung, M., Kim, Y., Yim, N., et al. (2010) Vitexin, Orientin and Other Flavonoids from Spirodela Polyrhiza Inhibit Adipogenesis in 3T3-L1 Cells. Phytotherapy Research, 24, 1543-1548. https://doi.org/10.1002/ptr.3186 |
| [33] | Devi, P.U., Ganasoundari, A., Rao, B.S.S. and Srinivasan, K.K. (1999) In Vivo Radioprotection by Ocimum Flavonoids: Survival of Mice. Radiation Research, 151, 74-78. https://doi.org/10.2307/3579750 |
| [34] | Da Silva, R.Z., Yunes, R.A., de Souza, M.M., Monache, F.D. and Cechinel-Filho, V. (2010) Antinociceptive Properties of Conocarpan and Orientin Obtained from Piper Solmsianum C. DC. Var. Solmsianum (Piperaceae). Journal of Natural Medicines, 64, 402-408. https://doi.org/10.1007/s11418-010-0421-x |
| [35] | 胡晓涵. 大黄素的体内外代谢研究[D]: [硕士学位论文]. 天津: 天津中医药大学, 2022. |
| [36] | Xuan, S.H., Hong, I.K., Lee, Y.J., Kim, J.W. and Park, S.N. (2019) Biological Activities and Chemical Components of Potentilla kleiniana Wight & Arn. Natural Product Research, 34, 3262-3266. https://doi.org/10.1080/14786419.2018.1557171 |
| [37] | 董爱文, 朱春艳, 卓琦. 五爪龙外敷液中芹菜素与槲皮素的HPLC测定[J]. 天然产物研究与开发, 2014, 26(2): 230-232. |
| [38] | 吕霞, 邓先军, 刁本恕. 刁本恕顽急证外治经验辑要[J]. 中医外治杂志, 2017, 26(5): 62-63. |
| [39] | 李艳, 张晓琳, 韦园园, 等. 委陵菜酸调控PI3K/Akt/mTOR通路对肝星状细胞活化增殖的影响[J]. 中成药, 2022, 44(6): 1965-1969. |
